Ricci Collineations of the Bianchi Types I and III, and Kantowski-Sachs Spacetimes

Ricci collineations of the Bianchi types I and III, and Kantowski-Sachs space- times are classified according to their Ricci collineation vector (RCV) field of the form (i)-(iv) one component of $\xi^a (x^b)$ is nonzero, (v)-(x) two components of $\xi^a (x^b)$ are nonzero, and (xi)-(xiv) three components of $\xi^a (x^b)$ are nonzero. Their relation with isometries of the space-times is established. In case (v), when $det(R_{ab}) = 0$, some metrics are found under the time transformation, in which some of these metrics are known, and the other ones new. Finally, the family of contracted Ricci collineations (CRC) are presented.Comment: 21 Pages, LaTeX, no figures, accepted for publication in the International Journal of Modern Physics

The Open Assembly Model for the Exchange of Assembly and Tolerance Information: Overview and Example

In early design phases an effective information exchange among CAD (Computer Aided Design) tools depends on a standardized representation for the product data in all PLM (Product Lifecycle Management) tools. The NIST Core Product Model (CPM) and its extension are proposed to provide the required base-level product model that is open, non-proprietary, generic, extensible, independent of any one product development process and capable of capturing the full engineering context commonly shared in product development [1]. The Open Assembly Model (OAM) Model extends CPM to provide a standard representation and exchange protocol for assembly. The assembly information model emphasizes the nature and information requirements for part features and assembly relationships. The model includes both assembly as a concept and assembly as a data structure. For the latter it uses the model data structures of ISO 10303, informally known as the Standard for the Exchange of Product model data (STEP)[2]. The objective of the paper is to show how the OAM can be used to realize seamless integration of product information, with an emphasis on assembly, throughout all phases of a product design. A gearbox design example is used to illustrate the process

The Open Assembly Model for the Exchange of Assembly and Tolerance Information: Overview and Example

In early design phases an effective information exchange among CAD (Computer Aided Design) tools depends on a standardized representation for the product data in all PLM (Product Lifecycle Management) tools. The NIST Core Product Model (CPM) and its extension are proposed to provide the required base-level product model that is open, non-proprietary, generic, extensible, independent of any one product development process and capable of capturing the full engineering context commonly shared in product development [1]. The Open Assembly Model (OAM) Model extends CPM to provide a standard representation and exchange protocol for assembly. The assembly information model emphasizes the nature and information requirements for part features and assembly relationships. The model includes both assembly as a concept and assembly as a data structure. For the latter it uses the model data structures of ISO 10303, informally known as the Standard for the Exchange of Product model data (STEP)[2]. The objective of the paper is to show how the OAM can be used to realize seamless integration of product information, with an emphasis on assembly, throughout all phases of a product design. A gearbox design example is used to illustrate the process

Micro-morphologic changes around biophysically-stimulated titanium implants in ovariectomized rats

<p>Abstract</p> <p>Background</p> <p>Osteoporosis may present a risk factor in achievement of osseointegration because of its impact on bone remodeling properties of skeletal phsiology. The purpose of this study was to evaluate micro-morphological changes in bone around titanium implants exposed to mechanical and electrical-energy in osteoporotic rats.</p> <p>Methods</p> <p>Fifteen 12-week old sprague-dowley rats were ovariectomized to develop osteoporosis. After 8 weeks of healing period, two titanium implants were bilaterally placed in the proximal metaphyses of tibia. The animals were randomly divided into a control group and biophysically-stimulated two test groups with five animals in each group. In the first test group, a pulsed electromagnetic field (PEMF) stimulation was administrated at a 0.2 mT 4 h/day, whereas the second group received low-magnitude high-frequency mechanical vibration (MECHVIB) at 50 Hz 14 min/day. Following completion of two week treatment period, all animals were sacrificed. Bone sites including implants were sectioned, removed <it>en bloc </it>and analyzed using a microCT unit. Relative bone volume and bone micro-structural parameters were evaluated for 144 μm wide peri-implant volume of interest (VOI).</p> <p>Results</p> <p>Mean relative bone volume in the peri-implant VOI around implants PEMF and MECHVIB was significantly higher than of those in control (<it>P </it>< .05). Differences in trabecular-thickness and -separation around implants in all groups were similar (<it>P </it>> .05) while the difference in trabecular-number among test and control groups was significant in all VOIs (<it>P </it>< .05).</p> <p>Conclusion</p> <p>Biophysical stimulation remarkably enhances bone volume around titanium implants placed in osteoporotic rats. Low-magnitude high-frequency MECHVIB is more effective than PEMF on bone healing in terms of relative bone volume.</p

High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients

<p>Abstract</p> <p>Background</p> <p>A significant portion of ovarian cancer (OC) cases is caused by germ-line mutations in BRCA1 or BRCA2 genes. BRCA testing is cheap in populations with founder effect and therefore recommended for all patients with OC diagnosis. Recurrent mutations constitute the vast majority of BRCA defects in Russia, however their impact in OC morbidity has not been yet systematically studied. Furthermore, Russian population is characterized by a relatively high frequency of CHEK2 and NBS1 (NBN) heterozygotes, but it remains unclear whether these two genes contribute to the OC risk.</p> <p>Methods</p> <p>The study included 354 OC patients from 2 distinct, geographically remote regions (290 from North-Western Russia (St.-Petersburg) and 64 from the south of the country (Krasnodar)). DNA samples were tested by allele-specific PCR for the presence of 8 founder mutations (BRCA1 5382insC, BRCA1 4153delA, BRCA1 185delAG, BRCA1 300T>G, BRCA2 6174delT, CHEK2 1100delC, CHEK2 IVS2+1G>A, NBS1 657del5). In addition, literature data on the occurrence of BRCA1, BRCA2, CHEK2 and NBS1 mutations in non-selected ovarian cancer patients were reviewed.</p> <p>Results</p> <p>BRCA1 5382insC allele was detected in 28/290 (9.7%) OC cases from the North-West and 11/64 (17.2%) OC patients from the South of Russia. In addition, 4 BRCA1 185delAG, 2 BRCA1 4153delA, 1 BRCA2 6174delT, 2 CHEK2 1100delC and 1 NBS1 657del5 mutation were detected. 1 patient from Krasnodar was heterozygous for both BRCA1 5382insC and NBS1 657del5 variants.</p> <p>Conclusion</p> <p>Founder BRCA1 mutations, especially BRCA1 5382insC variant, are responsible for substantial share of OC morbidity in Russia, therefore DNA testing has to be considered for every OC patient of Russian origin. Taken together with literature data, this study does not support the contribution of CHEK2 in OC risk, while the role of NBS1 heterozygosity may require further clarification.</p

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic1,2. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure. The mechanisms that determine such variable outcomes remain unresolved. Here we investigated CD4+ T cells that are reactive against the spike glycoprotein of SARS-CoV-2 in the peripheral blood of patients with COVID-19 and SARS-CoV-2-unexposed healthy donors. We detected spike-reactive CD4+ T cells not only in 83% of patients with COVID-19 but also in 35% of healthy donors. Spike-reactive CD4+ T cells in healthy donors were primarily active against C-terminal epitopes in the spike protein, which show a higher homology to spike glycoproteins of human endemic coronaviruses, compared with N-terminal epitopes. Spike-protein-reactive T cell lines generated from SARS-CoV-2-naive healthy donors responded similarly to the C-terminal region of the spike proteins of the human endemic coronaviruses 229E and OC43, as well as that of SARS-CoV-2. This results indicate that spike-protein cross-reactive T cells are present, which were probably generated during previous encounters with endemic coronaviruses. The effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined in larger cohorts. However, the presence of spike-protein cross-reactive T cells in a considerable fraction of the general population may affect the dynamics of the current pandemic, and has important implications for the design and analysis of upcoming trials investigating COVID-19 vaccines

7th Drug hypersensitivity meeting: part two

No abstract availabl

25th Annual Computational Neuroscience Meeting: CNS-2016

Abstracts of the 25th Annual Computational Neuroscience Meeting: CNS-2016 Seogwipo City, Jeju-do, South Korea. 2–7 July 201