13 research outputs found
Paraneoplastic Cutaneous Leukocytoclastic Vasculitis and Iron Deficiency Anemia As the Presenting Features of Squamous Cell Lung Carcinoma
Teaching qualitative research methods with Second Life, a 3-dimensional online virtual environment
Cognitive Behavior Therapy: A Potential Treatment for Depression among Asian Indian Immigrant Women in the United States
Evaluation of the Intricacies of Emotional Facial Expression of Psychiatric Patients Using Computational Models
Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women
Background and objectives: Matrix metalloproteinases (MMPs) are involved in several inflammatory processes including obesity-related vascular diseases and graft failure of coronary artery (CA) bypass grafts [internal mammary artery (IMA), saphenous vein (SV)]. In these inflammatory conditions, the release of prostaglandin E-2 (PGE(2)) is increased via the activity of inducible microsomal PGE synthase-1 (mPGES-1). Our aim was to investigate whether MMPs and their endogenous inhibitor (TIMPs) may be regulated by PGE(2) under inflammatory conditions in human vasculature and perivascular adipose tissue (PVAT), as well as in plasma of obese patients
The sweet spot: defining virus-sialic acid interactions
Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications