Guidelines for assessing favourable conservation status of Natura 2000 species and habitat types in Bulgaria

This executive summary describes the methodology for assessing the favourable conservation status of N2000 habitats and species on site level in Bulgaria and gives guidelines for its application. The methodology was developed in the frame of the BBI/Matra project 2006/014 “Favourable Conservation Status of Natura 2000 Habitat types and Species in Bulgaria”. The project was generously supported by the Dutch government under the BBI/Matra programme, which is a combination of two international policy programs of the Dutch government. The objectives and financial resources of the BBI/Matra Programme fall within the remit of the Matra Social Transformation Program of the Ministry of Foreign Affairs and under the International Policy Program on Biodiversity of the Ministry of Agriculture, Nature and Food Quality

Complexity and hierarchical game of life

Hierarchical structure is an essential part of complexity, important notion relevant for a wide range of applications ranging from biological population dynamics through robotics to social sciences. In this paper we propose a simple cellular-automata tool for study of hierarchical population dynamics

EARLY ATRIAL PACING TEST FOR MYOCARDIAL CONTRACTILITY EVALUATION IN PATIENTS WITH UNSTABLE ANGINA PECTORIS

No abstrac

RELATION BETWEEN THE REACTION TIME AND THE AMPLITUDE CHANGES OF THE H-REFLEX IN CASE OF SUCCESSIVE PLANTAR FLEXION OF THE FEET PERFORMED UNDER DIFFERENT EXPERIMENTAL CONDITIONS

No abstrac

Quasi-invariance of low regularity Gaussian measures under the gauge map of the periodic derivative NLS

The periodic DNLS gauge is an anticipative map with singular generator which revealed crucial in the study of the periodic derivative NLS. We prove quasi-invariance of the Gaussian measure on L2(T) with covariance [1+(−Δ)s]−1 under these transformations for any [Formula presented]. This extends previous achievements by Nahmod, Ray-Bellet, Sheffield and Staffilani (2011) and Genovese, Lucà and Valeri (2018), who proved the result for integer values of the regularity parameter s

EARLY VELOERGOMETRIC TEST AND ATRIAL PACING TEST IN PATIENTS WITH UNSTABLE ANGINA PECTORIS

No abstrac

APRIL:TACI axis is dispensable for the immune response to rabies vaccination.

There is significant need to develop a single-dose rabies vaccine to replace the current multi-dose rabies vaccine regimen and eliminate the requirement for rabies immune globulin in post-exposure settings. To accomplish this goal, rabies virus (RABV)-based vaccines must rapidly activate B cells to secrete antibodies which neutralize pathogenic RABV before it enters the CNS. Increased understanding of how B cells effectively respond to RABV-based vaccines may improve efforts to simplify post-exposure prophylaxis (PEP) regimens. Several studies have successfully employed the TNF family cytokine a proliferation-inducing ligand (APRIL) as a vaccine adjuvant. APRIL binds to the receptors TACI and B cell maturation antigen (BCMA)-expressed by B cells in various stages of maturation-with high affinity. We discovered that RABV-infected primary murine B cells upregulate APRIL ex vivo. Cytokines present at the time of antigen exposure affect the outcome of vaccination by influencing T and B cell activation and GC formation. Therefore, we hypothesized that the presence of APRIL at the time of RABV-based vaccine antigen exposure would support the generation of protective antibodies against RABV glycoprotein (G). In an effort to improve the response to RABV vaccination, we constructed and characterized a live recombinant RABV-based vaccine vector which expresses murine APRIL (rRABV-APRIL). Immunogenicity testing in mice demonstrated that expressing APRIL from the RABV genome does not impact the primary antibody response against RABV G compared to RABV alone. In order to evaluate the necessity of APRIL for the response to rabies vaccination, we compared the responses of APRIL-deficient and wild-type mice to immunization with rRABV. APRIL deficiency does not affect the primary antibody response to vaccination. Furthermore, APRIL expression by the vaccine did not improve the generation of long-lived antibody-secreting plasma cells (PCs) as serum antibody levels were equivalent in response to rRABV-APRIL and the vector eight weeks after immunization. Moreover, APRIL is dispensable for the long-lived antibody-secreting PC response to rRABV vaccination as anti-RABV G IgG levels were similar in APRIL-deficient and wild-type mice six months after vaccination. Mice lacking the APRIL receptor TACI demonstrated primary anti-RABV G antibody responses similar to wild-type mice following immunization with the vaccine vector indicating that this response is independent of TACI-mediated signals. Collectively, our findings demonstrate that APRIL and associated TACI signaling is dispensable for the immune response to RABV-based vaccination

Random data wave equations

Nowadays we have many methods allowing to exploit the regularising properties of the linear part of a nonlinear dispersive equation (such as the KdV equation, the nonlinear wave or the nonlinear Schroedinger equations) in order to prove well-posedness in low regularity Sobolev spaces. By well-posedness in low regularity Sobolev spaces we mean that less regularity than the one imposed by the energy methods is required (the energy methods do not exploit the dispersive properties of the linear part of the equation). In many cases these methods to prove well-posedness in low regularity Sobolev spaces lead to optimal results in terms of the regularity of the initial data. By optimal we mean that if one requires slightly less regularity then the corresponding Cauchy problem becomes ill-posed in the Hadamard sense. We call the Sobolev spaces in which these ill-posedness results hold spaces of supercritical regularity. More recently, methods to prove probabilistic well-posedness in Sobolev spaces of supercritical regularity were developed. More precisely, by probabilistic well-posedness we mean that one endows the corresponding Sobolev space of supercritical regularity with a non degenerate probability measure and then one shows that almost surely with respect to this measure one can define a (unique) global flow. However, in most of the cases when the methods to prove probabilistic well-posedness apply, there is no information about the measure transported by the flow. Very recently, a method to prove that the transported measure is absolutely continuous with respect to the initial measure was developed. In such a situation, we have a measure which is quasi-invariant under the corresponding flow. The aim of these lectures is to present all of the above described developments in the context of the nonlinear wave equation.Comment: Lecture notes based on a course given at a CIME summer school in August 201

The phase shift of line solitons for the KP-II equation

The KP-II equation was derived by [B. B. Kadomtsev and V. I. Petviashvili,Sov. Phys. Dokl. vol.15 (1970), 539-541] to explain stability of line solitary waves of shallow water. Stability of line solitons has been proved by [T. Mizumachi, Mem. of vol. 238 (2015), no.1125] and [T. Mizumachi, Proc. Roy. Soc. Edinburgh Sect. A. vol.148 (2018), 149--198]. It turns out the local phase shift of modulating line solitons are not uniform in the transverse direction. In this paper, we obtain the $L^\infty$-bound for the local phase shift of modulating line solitons for polynomially localized perturbations

Numerical study of oscillatory regimes in the Kadomtsev-Petviashvili equation

The aim of this paper is the accurate numerical study of the KP equation. In particular we are concerned with the small dispersion limit of this model, where no comprehensive analytical description exists so far. To this end we first study a similar highly oscillatory regime for asymptotically small solutions, which can be described via the Davey-Stewartson system. In a second step we investigate numerically the small dispersion limit of the KP model in the case of large amplitudes. Similarities and differences to the much better studied Korteweg-de Vries situation are discussed as well as the dependence of the limit on the additional transverse coordinate.Comment: 39 pages, 36 figures (high resolution figures at http://www.mis.mpg.de/preprints/index.html