865 research outputs found
How the Sex Industry Market Determines the Distribution of Smuggling Hot Spots in Taiwan: An Empirical Study of Illegal Immigration of Mainland Chinese Females to Taiwan
DISTRIBUTION OF GRIP PRESSURE THROUGHOUT THE PHASES OF PUTTING IN ELITE GOLF COLLEGE PLAYERS
The purpose of this study is to investigate the distribution of grip pressure, force and the peak pressure of different phases during the putting stroke. Five elite college players with handicaps of 2-8 participated in the study. The Novel Pliance-x System and 150Hz 8- camera Motion Analysis Corporation System were used to collect grip pressure and identify each phase of the putting stroke. At each phase of the putting stroke, average grip pressure, peak pressure and grip force were investigated. Results indicated that lowest grip pressure occurred at address up to the top of backswing (2.41±1.36 Kpa). Grip pressure started to increase during the downswing and reached its peak, 0.02±0.05s, before impact (4.70±1.97 Kpa). The pressure reduced again after impact (4.36±2.06 Kpa). Results indicate that grip pressure does not remain the same throughout the stroke
Mechanical ball shear, electromigration, and thermal cycling reliability testing on novel solder interconnects of highly integrated chips for advanced applications
In the near future, Ultra Large Scale Integrated Circuits (ULSI) with high integration has drawn the huge attention because of its potential applications in VR, AI, IoTs and automotive regions. Thermal budget and reliability concerns are two major issues that are urgently needed to be solved for these technologies. Since the increasing integration of ICs might lead to low yield concern, low fabrication temperature is expected to reduce the thermal impact on ICs properties. Besides, better reliability is also required to the electric devices for those to work under harsh outdoor environments. This study is tended to be focused on the novel solder bonds for the advanced ICs, including low temperature solder, Cu-core solder ball, and their response under various reliability tests. Three main reliability tests: (1) ball shear test, (2) electromigration test (EM) and (3) thermal cycling test (TCT), are conducted to evaluate the reliability of solder bonds. In this work, the novel Bi-40In solder alloy with improved mechanical property and the EM-resisted Cu-core solder ball are demonstrated. The re-designed low temperature solder joint reveals the superior ball shear strength than that of conventional eutectic Bi-33In joint. Additionally, the interconnects using Cu-core solder ball show the high resistance against EM under current stressing. Regarding TCT, the assemble joints with various grain structures are tested to realize the effects of Sn grain size on joint degradation and the possible ways for relieving the thermomechanical stress caused by TCT. The microstructure, elemental characteristics and grain structure are analyzed by FE-SEM, FE-EPMA and EBSD, respectively. The failure mechanisms for all reliability tests are addressed and discussed in details as well
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Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.
Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft environments modulate neurite initiation remains elusive. Using hydrogel cultures, pharmacologic inhibition, and genetic approaches, we reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner. On soft substrates, most paxillin binds to endocytic factors and facilitates vesicle invagination, elevating neuritogenic Rac1 activity and expression of genes encoding the endocytic machinery. By contrast, on rigid substrates, cells develop extensive adhesions, increase RhoA activity and sequester paxillin from the endocytic machinery, thereby delaying neurite initiation. Our results highlight paxillin as a core molecule in substrate modulus-controlled morphogenesis and define a mechanism whereby neuronal cells respond to environments exhibiting varying mechanical properties
AVATAR: Robust Voice Search Engine Leveraging Autoregressive Document Retrieval and Contrastive Learning
Voice, as input, has progressively become popular on mobiles and seems to
transcend almost entirely text input. Through voice, the voice search (VS)
system can provide a more natural way to meet user's information needs.
However, errors from the automatic speech recognition (ASR) system can be
catastrophic to the VS system. Building on the recent advanced lightweight
autoregressive retrieval model, which has the potential to be deployed on
mobiles, leading to a more secure and personal VS assistant. This paper
presents a novel study of VS leveraging autoregressive retrieval and tackles
the crucial problems facing VS, viz. the performance drop caused by ASR noise,
via data augmentations and contrastive learning, showing how explicit and
implicit modeling the noise patterns can alleviate the problems. A series of
experiments conducted on the Open-Domain Question Answering (ODSQA) confirm our
approach's effectiveness and robustness in relation to some strong baseline
systems
A Hierarchical Context-aware Modeling Approach for Multi-aspect and Multi-granular Pronunciation Assessment
Automatic Pronunciation Assessment (APA) plays a vital role in
Computer-assisted Pronunciation Training (CAPT) when evaluating a second
language (L2) learner's speaking proficiency. However, an apparent downside of
most de facto methods is that they parallelize the modeling process throughout
different speech granularities without accounting for the hierarchical and
local contextual relationships among them. In light of this, a novel
hierarchical approach is proposed in this paper for multi-aspect and
multi-granular APA. Specifically, we first introduce the notion of sup-phonemes
to explore more subtle semantic traits of L2 speakers. Second, a depth-wise
separable convolution layer is exploited to better encapsulate the local
context cues at the sub-word level. Finally, we use a score-restraint attention
pooling mechanism to predict the sentence-level scores and optimize the
component models with a multitask learning (MTL) framework. Extensive
experiments carried out on a publicly-available benchmark dataset, viz.
speechocean762, demonstrate the efficacy of our approach in relation to some
cutting-edge baselines.Comment: Accepted to Interspeech 202
Probing the DNA kink structure induced by the hyperthermophilic chromosomal protein Sac7d
Sac7d, a small, abundant, sequence-general DNA-binding protein from the hyperthermophilic archaeon Sulfolobus acidocaldarius, causes a single-step sharp kink in DNA (âŒ60°) via the intercalation of both Val26 and Met29. These two amino acids were systematically changed in size to probe their effects on DNA kinking. Eight crystal structures of five Sac7d mutantâDNA complexes have been analyzed. The DNA-binding pattern of the V26A and M29A single mutants is similar to that of the wild-type, whereas the V26A/M29A protein binds DNA without side chain intercalation, resulting in a smaller overall bending (âŒ50°). The M29F mutant inserts the Phe29 side chain orthogonally to the C2pG3 step without stacking with base pairs, inducing a sharp kink (âŒ80°). In the V26F/M29F-GCGATCGC complex, Phe26 intercalates deeply into DNA bases by stacking with the G3 base, whereas Phe29 is stacked on the G15 deoxyribose, in a way similar to those used by the TATA box-binding proteins. All mutants have reduced DNA-stabilizing ability, as indicated by their lower T(m) values. The DNA kink patterns caused by different combinations of hydrophobic side chains may be relevant in understanding the manner by which other minor groove-binding proteins interact with DNA
The characterization of the saddle shaped nickel(III) porphyrin radical cation: an explicative NMR model for a ferromagnetically coupled metallo-porphyrin radical
Ni(III)(OETPPË)(Br)2 is the first Ni(III) porphyrin radical cation with structural and (1)H and (13)C paramagnetic NMR data for porphyrinate systems. Associating EPR and NMR analyses with DFT calculations as a new model is capable of clearly determining the dominant state from two controversial spin distributions in the ring to be the Ni(III) LS coupled with an a1u spin-up radical
An in situ study on the coalescence of monolayer-protected Au-Ag nanoparticle deposits upon heating
The structural evolution of thiolate-protected nanoparticles of gold, silver, and their alloys with various Au/Ag ratios (3:1, 1:1, and 1:3) upon heating was investigated by means of in situ synchrotron radiation X-ray diffraction. The relationships between the coalescence and composition of nanoparticles, as well as the surfactant reactions, were clarified. Experimental results show that there existed a critical temperature ranging from 120°C to 164°C, above which the tiny broad X-ray diffraction peaks became sharp and strong due to particle coalescence. The coalescence temperatures for alloy nanoparticle deposits were clearly lower than those for pure metals, which can be ascribed to the rivalry between the thermodynamic effect due to alloying and the interactions between surface-assembled layers and the surface atoms of the nanoparticles. The strong affinity of thiolates to Ag and thus complex interactions give rise to a greater energy barrier for the coalescence of nanoparticles into the bulk and subsequent high coalescence temperature. The influences of particle coalescence on the optical and electrical properties of the nanoparticle deposits were also explored
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