Digital documentation and planning of student projects in engineering and product design using e-portfolios

The use of e-portfolios is very rare among academic teaching on engineering design and product design especially in Germany. Written exams and reports are not always suitable to evaluate competencies and skills of students gained through such projects. A wide range of competencies is required and a variety of results (sketches, 3D-CAD-models, real prototypes, user feedback, etc.) are generated, that cannot be adequately represented in a written exam or report. We see the use of e-portfolios as a solution to this problem. Our goal is to enable the documentation and planning of the entire product design process using e-portfolios for student projects in a course on product design - and thus also include the production and assembly of the individual parts until the real final product. This short-paper will detail the necessary preparations and changes in content and organization to a course on product design and how the students are introduced to the use of e-portfolios. We develop a three-step process, that supports i) the preparation of e-portfolios (in advance to the course), ii) the design of individual e-portfolios (during the course) and iii) the evaluation at the end of the course. The main findings of this work are seen in a provided recommendation on structure and design of an e-portfolio based course on product design (integrating required and useful software-tools and manufacturing machine interfaces) as well as the identified specific requirements of students and lecturers that need to be fulfilled to successfully implement e-portfolios

Cytotoxicity of reductive metabolites of thimerosal

Bei Thiomersal handelt es sich um ein quecksilberhaltiges Konservierungsmittel in Medizinprodukten, welches auch in Impfstoffen Verwendung findet. In dieser Arbeit wurden die Toxizität von Thiomersal und von Glutathionkonjugaten seiner Dissoziationsprodukte sowie zum Vergleich die Toxizität von zwei strukturell mit Thiomersal bzw. seinen Metaboliten verwandten Referenzsubstanzen, p-Chlormercuribenzoesäure und Ethylquecksilberchlorid, in Zellsystemen mit humanen Zellen vom Typ A-549 und Hep-G2 untersucht. Alle fünf Substanzen führten zu einer dosisabhängigen Vitalitätsreduktion bei beiden Zelllinien. Die stärkste Vitalitätsreduktion wurde durch Ethylquecksilberchlorid erzielt, danach folgten in absteigender Reihenfolge Thiomersal, Ethylquecksilber-L-Glutathion und p-Chlormercuribenzoesäure. Den schwächsten vitalitätsreduzierenden Effekt zeigte Thiosalicyl-L-Glutathion-Disulfid. Diese Ergebnisse sprechen dafür, dass die Glutathion-Konjugation von Thiomersal zu einer Abschwächung der Toxizität im menschlichen Organismus führt und untermauern die Annahme einer protektiven Wirkung von Glutathion. Die giftende Rolle von Glutathion in Bioaktivierungsprozessen anderer Noxen wird diskutiert. Es wurde im Rahmen dieser Arbeit ein Beitrag zum besseren Verständnis der Toxizität von Thiomersal im humanen Organismus geleistet und darüber hinaus Bezüge zum potentiellen allergenen Potential von Thiomersal hergestellt

Having a real prototype of your own product design – small effort but big eureka moment for students

[EN] This paper presents a project-based product design course, which is the only course on product design in our curriculum. We noticed that the building of a prototype is often omitted in academic teaching. However, students benefit from building a prototype of their design. Hence, we reduced the theoretical content to give students time to design and build a prototype. To illustrate the course two student projects are shown. We want to motivate lecturers to introduce prototyping to courses, since our experience is that the benefits of building a prototype outweigh the decrease in theoretical knowledge.Riess, C.; Walter, M.; Tyroller, M.; Gomolka, L.; Augustin, J.; Altieri, M. (2023). Having a real prototype of your own product design – small effort but big eureka moment for students. Editorial Universitat Politècnica de València. 266-279. https://doi.org/10.4995/BMT2022.2022.1562426627