Alumina and Synthesis Intermediates Derived from Diethylkaluminum Amide, Benzaldehyde and Water

The reaction of diethylaluminum amide [Et2AINH2] with benzaldehyde in toluene produces a solution of ethylaluminoxane polymer [EtAlO] and hydrobenzamide [PhCH=NCH(Ph)N=CHPh]. Alumina then is precipitated by the addition of water. Transition aluminas that may be useful in heterogeneous catalyst applications are obtained after calcining. Details of the chemistry of solution intermediates according to 1H NMR and the properties of the alumina product according to surface area analyses and powder x-ray diffraction are described

Automating CapCom Using Mobile Agents and Robotic Assistants

Mobile Agents (MA) is an advanced Extra-Vehicular Activity (EVA) communications and computing system to increase astronaut self-reliance and safety, reducing dependence on continuous monitoring and advising from mission control on Earth. MA is voice controlled and provides information verbally to the astronauts through programs called “personal agents.” The system partly automates the role of CapCom in Apollo-including monitoring and managing navigation, scheduling, equipment deployment, telemetry, health tracking, and scientific data collection. Data are stored automatically in a shared database in the habitat/vehicle and mirrored to a site accessible by a remote science team. The program has been developed iteratively in authentic work contexts, including six years of ethnographic observation of field geology. Analog field experiments in Utah enabled empirically discovering requirements and testing alternative technologies and protocols. We report on the 2004 system configuration, experiments, and results, in which an EVA robotic assistant (ERA) followed geologists approximately 150 m through a winding, narrow canyon. On voice command, the ERA took photographs and panoramas and was directed to serve as a relay on the wireless network

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

SummaryAlzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Aβ42 levels without inhibiting epsilon-site cleavage of APP and Notch, the generation of the APP and Notch intracellular domains, respectively. These compounds also reduced Aβ40 levels while concomitantly elevating levels of Aβ38 and Aβ37. Immobilization of a potent GSM onto an agarose matrix quantitatively recovered Pen-2 and to a lesser degree PS-1 NTFs from cellular extracts. Moreover, oral administration (once daily) of another potent GSM to Tg 2576 transgenic AD mice displayed dose-responsive lowering of plasma and brain Aβ42; chronic daily administration led to significant reductions in both diffuse and neuritic plaques. These effects were observed in the absence of Notch-related changes (e.g., intestinal proliferation of goblet cells), which are commonly associated with repeated exposure to functional gamma-secretase inhibitors (GSIs)

Trends in Stage-Specific Incidence Rates for Urothelial Carcinoma of the Bladder in the United States: 1988 to 2006

Bladder cancer is notable for a striking heterogeneity of disease-specific risks. Among the approximately 75% of incident cases found to be superficial to the muscularis propria at the time of presentation (non-muscle-invasive bladder cancer), the risk of progression to the lethal phenotype of muscle-invasive disease is strongly associated with stage and grade of disease. Given the suggestion of an increasing percentage of low-risk cases in hospital-based registry data in recent years, the authors hypothesized that population-based data may reveal changes in the stage distribution of early-stage cases

Patterns of care in older patients with squamous cell carcinoma of the head and neck: A Surveillance, Epidemiology, and End Results-Medicare analysis

There is growing evidence in the literature that older patients may not benefit from more intensive therapy for Head and Neck Squamous Cell Carcinoma (HNSCC). A growing number of patients with Head and Neck Squamous Cell Carcinoma (HNSCC) are age 65 and older; however, much of the evidence base informing treatment decisions is based on substantially younger and healthier clinical trial populations. The purpose of this study was to assess the patterns of care of older HNSCC patients to better understand how age is associated with treatment decision

Evidence of water ice near the lunar poles

Lunar Prospector epithermal neutron data were studied to evaluate the probable chemical state of enhanced hydrogen, [H], reported previously to be near both lunar poles [1,2]. Improved versions of thermal and epithermal neutron data were developed for this purpose. Most important is the improved spatial resolution obtained by using shortened integration times. A new data set was created, Epi* = [Epithermal - 0.057 x Thermal], to reduce effects of composition variations other than those due to hydrogen. The Epi* counting rates are generally low near both lunar poles and high over terrane near recent impact events such as Tycho and Jackson. However, other lunar features are also associated with high Epi* rates, which represent a wide range of terrane types that seem to have little in common. If we postulate that one property all bright Epi* features do have in common is low [H], then measured Epi* counting rates appear to be quantitatively self consistent. If we assume that [H]=O above the top 98th percentile of Epi* counting rates at 2{sup o} x 2{sup o} spatial resolution, then [H]{sub ave} = 55 ppm for latitudes equatorward of [75{sup o}]. This value is close to the average found in returned lunar soil samples, [H]{sub ave} {approx} 50 ppm [3]. Using the foregoing physical interpretation of Epi* counting rates, we find that the Epi* counts within most of the large craters poleward of {+-}70{sup o} are higher, and therefore [H] is lower, than that in neighboring inter-crater plains, as shown in Figure 1. Fourteen of these craters that have areas larger than the LP epithermal spatial resolution (55 km diameter at 30 km altitude), were singled out for study. [H] is generally found to increase with decreasing distance from the poles (hence decreasing temperature). However, quantitative estimates of the diffusivity of hydrogen at low temperature show that diffusion can not be an important factor in explaining the difference between the relatively low [H] observed within the large sunlit polar craters and the relatively high [H] in neighboring inter-crater plains. A closer look at the 'inter-crater' plains near the poles, shows that they are covered by many small craters that harbor permanent shade [4]. The temperatures within many of these craters are low enough [5] that they can disable sublimation as a viable loss process of [H{sub 2}O]. It is therefore tempting to postulate that the enhanced hydrogen within most regions of permanent shade is in the form of water molecules. This postulate is certainly viable within the bottoms of several large, permanently shaded craters near the south pole. Predicted temperatures within them [5] fall well below the 100 K temperature that is needed to stabilize water ice for aeons. The picture is different near the north pole. Here, there are relatively few permanently-shaded craters that are large enough to harbor temperatures that are sufficiently low to stabilize water ice indefinitely against sublimation [5]. Instead, the 'inter-crater' polar plains are a jumble of many permanently-shaded craters that have diameters less than 10 km [4]. Although simulations of temperatures within this class of craters show they are only marginally cold enough to indefinitely stabilize water ice [5], this terrane appears to have the highest [H]. Nevertheless, predicted temperatures are close enough to that needed to permanently stabilize [H{sub 2}O] to suggest that sublimation is indeed the process that discriminates between polar terrane that contains enhanced [H] and those that do not (see, e.g., the temperature estimates for doubly-shaded craters [6]). If correct, then an important fraction of the hydrogen near the north pole must be in the form of H{sub 2}O, which then resides within these small craters. Estimates using our improved data set of [H] within craters near the south pole remain unchanged from those derived from our previous analysis [2], [H] = 1700{+-}900 ppm. This translates to [H{sub 2}O]=1.5{+-}0.8%. If all of the enhanced hydrogen in the north is in the form of H{sub 2}O and is confined to the jumble of small permanently-shaded craters identified by radar [4], then we can estimate their water-ice fraction, [H{sub 2}O], using Figure 1a in [2]. We chose two regions near the north pole for this purpose. They each have areas just larger than the surface foot-print of the LP epithermal neutron spectrometer. The first was an inter-crater region nestled between Rozhdestvenskiy and Plaskett, and the second covered the southeast comer of Peary. Using Figure 3 of [4], the first area contains 232 km{sup 2} of measured permanent shade, and the second contains 129 km{sup 2}. Adopting the prescription used in Table 1 of [4] for estimating actual from sampled shaded areas, multiplication of sampled areas by 1.5 yields permanently shaded areas that amount to 350 km{sup 2} in region 1, and 200 km{sup 2} in the southeast comer of Peary

The Mobile Agents Integrated Field Test: The Mars Desert Research Station April 2003

The Mobile Agents model-based, distributed architecture, which integrates diverse components in a system for lunar and planetary surface operations, was extensively tested in a two-week field “technology retreat ” at the Mars Society’s Desert Research Station (MDRS) during April 2003. More than twenty scientists and engineers from three NASA centers and two universities refined and tested the system through a series of incremental scenarios. Agent software, implemented in runtime Brahms, processed GPS, health data, and voice commands—monitoring, controlling and logging science data throughout simulated EVAs with two geologists. Predefined EVA plans, modified on the fly by voice command, enabled the Mobile Agents system to provide navigation and timing advice. Communications were maintained over five wireless nodes distributed over hills and into canyons for 5 km; data, including photographs and status was transmitted automatically to the desktop at mission control in Houston. This paper describes the system configurations, communication protocols, scenarios, and test results. Backgroun

Mobile Agents: A Distributed Voice-Commanded Sensory and Robotic System for Surface EVA Assistance

A model-based, distributed architecture integrates diverse components in a system designed for lunar and planetary surface operations: spacesuit biosensors, cameras, GPS, and a robotic assistant. The system transmits data and assists communication between the extra-vehicular activity (EVA) astronauts, the crew in a local habitat, and a remote mission support team. Software processes ("agents"), implemented in a system called Brahms, run on multiple, mobile platforms, including the spacesuit backpacks, all-terrain vehicles, and robot. These "mobile agents" interpret and transform available data to help people and robotic systems coordinate their actions to make operations more safe and efficient. Different types of agents relate platforms to each other ("proxy agents"), devices to software ("comm agents"), and people to the system ("personal agents"). A state-of-the-art spoken dialogue interface enables people to communicate with their personal agents, supporting a speech-driven navigation and scheduling tool, field observation record, and rover command system. An important aspect of the engineering methodology involves first simulating the entire hardware and software system in Brahms, and then configuring the agents into a runtime system. Design of mobile agent functionality has been based on ethnographic observation of scientists working in Mars analog settings in the High Canadian Arctic on Devon Island and the southeast Utah desert. The Mobile Agents system is developed iteratively in the context of use, with people doing authentic work. This paper provides a brief introduction to the architecture and emphasizes the method of empirical requirements analysis, through which observation, modeling, design, and testing are integrated in simulated EVA operations

Dynamics of Catalytic Resolution of 2‑Lithio‑<i>N</i>‑Boc-piperidine by Ligand Exchange

The dynamics of the racemization and catalytic and stoichiometric dynamic resolution of 2-lithio-<i>N</i>-Boc-piperidine (<b>7</b>) have been investigated. The kinetic order in tetramethylethylenediamine (TMEDA) for both racemization and resolution of the title compound and the kinetic orders in two resolving ligands have been determined. The catalytic dynamic resolution is second order in TMEDA and 0.5 and 0.265 order in chiral ligands <b>8</b> and <b>10</b>, respectively. The X-ray crystal structure of ligand <b>10</b> shows it to be an octamer. Dynamic NMR studies of the resolution process were carried out. Some of the requirements for a successful catalytic dynamic resolution by ligand exchange have been identified