714 research outputs found
Nurses\u27 Alumnae Association Bulletin, April 1962
Staff Nurses Association
Alumnae Meetings 1961
Social Committee
Clara Melville Scholarship Fund
Ways and Means Report
Cook Book Report
Bulletin Committee
Private Duty Nurse\u27s Section
Hospital Report and Nursing Service
Federal Nursing Service
Practice of Nursing
Report of Student Council Activities
Medical Work in Ghan
An investigation of linting and fluffing of offset newsprint. Project 2949, report four : a progress report to Members of Group Project 2949
"August 23, 1974.""The Institute of Paper Chemistry ... Betty John, Russell F. Tyler, and Robert M. Leekley.
Nurses\u27 Alumnae Association Bulletin, April 1959
Alumnae News
Anniversary Class of /34
Article from Pennsylvania Nurse
Committee Reports
Current Events at Jefferson
Greetings from the President
Jefferson Story
Lost Members
Letter - Past President
Marriages
Necrology
New Arrivals
Notices
Pictured - Student Nurses\u27 Residence
Report of the School of Nursing and Nursing Services
Staff Nurses Social Functions
Student Activities
Voluntary Service
Year of Great Activity and Expansio
Nurses\u27 Alumnae Association Bulletin, June 1965
President\u27s Page
Officers and Committee Chairmen
Financial Report
Hospital and School of Nursing Report
Student Activities Annual Report
Students Activities Annual Report
Student Activities Annual Report
Jefferson Expansion Program
Psychiatric Unit
Progress of the Alumnae Association
Nightingale Pledge
Resume of Alumnae Meetings
Nursing Service Staff Association
Scholarship
Program
Sick and Welfare
Social Committee Report
Bulletin
Membership- WHY JOIN?
Private Duty Report
Annual Giving Report - 1964
PIT
Alumnae Day Notes
Building Fund Report - 1965
Vital Statistics
IN MEMORIAM
Class News
Affiliated Institutions
Notice
Nurses\u27 Alumnae Association Bulletin, June 1964
President\u27s Message
Officers and Committee Chairmen
Financial Report
Hospital and School of Nursing Report
Student Activities
Jefferson Expansion Program
Resume of Alumnae Meetings
Staff Nurses
Private Duty
Social Committee Reports
Program
Scholarship
Bulletin Committee Report
Annual Luncheon Notes
Membership and Dues
Units in Jefferson Expansion Program Center
Annual Giving Drive 1963
Report of Ways and Means Committee
Jefferson Building Fund Contributions
Annual Giving Contributions 1964
Jefferson Building Fund Report
Help the Building Fund Committee!
Vital Statistics
Class News
Notice
Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain
Metastases represent the most common brain tumors in adults. Surgical resection alone results in 45% recurrence and is usually accompanied by radiation and chemotherapy. Adequate chemotherapy delivery to the CNS is hindered by the blood–brain barrier. Efforts at delivering chemotherapy locally to gliomas have shown modest increases in survival, likely limited by the infiltrative nature of the tumor. Temozolomide (TMZ) is first-line treatment for gliomas and recurrent brain metastases. Doxorubicin (DOX) is used in treating many types of breast cancer, although its use is limited by severe cardiac toxicity. Intracranially implanted DOX and TMZ microcapsules are compared with systemic administration of the same treatments in a rodent model of breast adenocarcinoma brain metastases. Outcomes were animal survival, quantified drug exposure, and distribution of cleaved caspase 3. Intracranial delivery of TMZ and systemic DOX administration prolong survival more than intracranial DOX or systemic TMZ. Intracranial TMZ generates the more robust induction of apoptotic pathways. We postulate that these differences may be explained by distribution profiles of each drug when administered intracranially: TMZ displays a broader distribution profile than DOX. These microcapsule devices provide a safe, reliable vehicle for intracranial chemotherapy delivery and have the capacity to be efficacious and superior to systemic delivery of chemotherapy. Future work should include strategies to improve the distribution profile. These findings also have broader implications in localized drug delivery to all tissue, because the efficacy of a drug will always be limited by its ability to diffuse into surrounding tissue past its delivery source.National Institutes of Health (U.S.) (Grant R01 EB006365-06)Brain Science Foundation (Private Grant 106708
Expressions 1987
https://openspace.dmacc.edu/expressions/1030/thumbnail.jp
Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste
Purpose: High-grade glioma (HGG) treatment is limited by the inability of otherwise potentially efficacious drugs to penetrate the blood brain barrier. We evaluate the unique intra-cavity delivery mode and translational potential of a blend of poly(DL-lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) paste combining temozolomide and etoposide to treat surgically resected HGG. Experimental Design: To prolong stability of temozolomide pro-drug, combined in vitro drug release was quantitatively assessed from low pH-based PLGA/PEG using advanced analytical methods. In vitro cytotoxicity was measured against a panel of HGG cell lines and patient-derived cultures using metabolic assays. In vivo safety and efficacy was evaluated using orthotopic 9L gliosarcoma allografts, previously utilized pre-clinically to develop Gliadel®. Results: Combined etoposide and temozolomide in vitro release (22 and 7 days respectively) was achieved from a lactic acid-based PLGA/PEG paste, used to enhance stability of temozolomide prodrug. HGG cells from central-enhanced regions were more sensitive to each compound relative to primary lines derived from the HGG invasive margin. Both drugs retained cytotoxic capability upon release from PLGA/PEG. In vivo studies revealed a significant overall survival benefit in post-surgery 9L orthotopic gliosarcomas treated with intra-cavity delivered PLGA/PEG/temozolomide/etoposide and enhanced with adjuvant radiotherapy. Long-term survivorship was observed in over half the animals with histological confirmation of disease-free brain. Conclusions: The significant survival benefit of intra-cavity chemotherapy demonstrates clinical applicability of PLGA/PEG paste-mediated delivery of temozolomide and etoposide adjuvant to radiotherapy. PLGA/PEG paste offers a future platform for combination delivery of molecular targeted compounds
Alumni Association Bulletin of the School of Nursing, 1976
Alumni Calendar
The President\u27s Message
Officers and Chairpersons of Committees
Financial Report
Annual Reports
New Surgical Concept for Laryngeal Cancer
Computerized Transaxial X-ray Scanner
Dental Health Center
The Winged Ox of St. Luke
Pictures - New Building
Committee Reports
Resume of Alumni Minutes
Ways and Means Report
Alumni News
Class News
Names and Addresses of 1976 Graduates
School of Nursing 1976 Awards
Marriages
Births
In Memoriam - List of Alumni
In Memoriam - Dr. Peter A. Herbut
In Memoriam - Miss Katherine Childs
Change of Address Notice
Notice
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