Model for Forming the Interregional Cluster of the Alternative Energy

The relevance of the research is due to the necessity of improving Russia's environmental and economic policy at the present stage and ensuring sustainable environmental and economic development of the Russian economy. One of the main strategic priorities of the latter is the development of alternative energy, which will contribute to higher energy and environmental efficiency as well as to easing the load on the environment. It will also involve optimization of the structure of the country's balance of energy owing to reducing its dependence on the export of organic fuels and to ensuring innovation development of the energy industry for the long term. With regard to this, the paper is aimed at finding the most efficient way for solving the said problem; as one, it is shaping the interregional cluster of alternative energy that is suggested by the authors. The leading approach to studying this problem is the systemic approach enabling an integrated view of the diverse elements (alternative energy, cluster approach, interregional interaction) that used to be considered individually. In the paper, the necessity of developing alternative energy is justified as one of the focus areas for ensuring Russia's sustainable environmental and economic development which requires the relevant material, labor and financial resources, technologies and equipment. In order to generate these, it is suggested to form the interregional cluster of alternative energy based on one of the four presented interregional interaction models, namely, the multilateral cross-sectoral model which is going to incorporate mutually associated sectors of the economy (producer sectors, supplier sectors, and consumer sectors) located in several regions and aimed at solving the shared problems. The materials of the paper are of practical value for the state and municipal authorities of Russia in terms of improving the policy implemented by them within sustainable development. Moreover, the results of the paper can be taken into account in forming an entire range of regulatory instruments and social and economic development programs for Russia in general and its regions in particular. Keywords: Alternative energy; cluster approach; interregional cluster; region; cluster policy JEL Classifications: C38, Q01, Q2, Q42 DOI: https://doi.org/10.32479/ijeep.795

Structured matrices, continued fractions, and root localization of polynomials

We give a detailed account of various connections between several classes of objects: Hankel, Hurwitz, Toeplitz, Vandermonde and other structured matrices, Stietjes and Jacobi-type continued fractions, Cauchy indices, moment problems, total positivity, and root localization of univariate polynomials. Along with a survey of many classical facts, we provide a number of new results.Comment: 79 pages; new material added to the Introductio

Действие акадезина на клетки рака молочной железы в условиях гипоксии

The riboside derivative acadesine (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) is currently being tested in clinical trials as a promising anti-tumor drug. Intracellular target of acadesine is adenosine monophosphate-activated protein kinase (АМРК), an important regulatory molecule of energy metabolism. It is expected that acadesine would be active in tumors under hypoxia conditions. In normoxia (cells incubated in 21 % oxygen), acadesine inhibited proliferation and induced cell death of breast adenocarcinoma, including the triple negative breast cancer line. When oxygen partial pressure was decreased to 1 % (experimental hypoxia), acadesine inhibited activation of reporter construct responsive to HIF-1α (hypoxia inducible factor 1 alpha) transcription factor. This effect was observed for acadesine in concentrations close to cytotoxic. Acadesine retained cytotoxicity under hypoxia and decreased the survival of the MDA-MB-231 cell line when used in combination with cisplatin. These results considerably widen acadesine’s field of application and allow to assume its efficacy in chemotherapy combination regimens for breast cancer, including the tumors with low oxygenation.Производное рибозида акадезин (5‑аминоимидазол-4‑карбоксамид-1‑β-D-рибофуранозид) проходит клинические испытания как перспективный противоопухолевый препарат. Внутриклеточная мишень акадезина аденозинмонофосфат-активируемая протеинкиназа (АМРК, adenosine monophosphate-activated protein kinase) – важный регулятор энергетического метаболизма. Правомерно предположить, что акадезин окажется активен в условиях гипоксии опухолей. В нормоксии (инкубация клеток в атмосфере с 21 % кислорода) акадезин вызывал торможение пролиферации и гибель клеток аденокарциномы молочной железы, в том числе линии трижды негативного рака. При снижении парциального давления кислорода до 1 % (экспериментальная гипоксия) акадезин ингибировал активацию промотор-репортерной конструкции, обусловленную транскрипционным фактором HIF-1α (hypoxia inducible factor 1 alpha). Этот эффект наблюдали при действии акадезина в концентрациях, сопоставимых с цитотоксическими. Акадезин сохранял цитотоксичность в условиях гипоксии и снижал обусловленную гипоксией устойчивость клеток линии MDA-MB-231 к действию цисплатина. Эти результаты расширяют область применения акадезина и позволяют предположить его эффективность в комбинированных режимах лекарственной терапии рака молочной железы, в том числе для опухолей с низкой оксигенацией