6 research outputs found
Model for Forming the Interregional Cluster of the Alternative Energy
The relevance of the research is due to the necessity of improving Russia's environmental and economic policy at the present stage and ensuring sustainable environmental and economic development of the Russian economy. One of the main strategic priorities of the latter is the development of alternative energy, which will contribute to higher energy and environmental efficiency as well as to easing the load on the environment. It will also involve optimization of the structure of the country's balance of energy owing to reducing its dependence on the export of organic fuels and to ensuring innovation development of the energy industry for the long term. With regard to this, the paper is aimed at finding the most efficient way for solving the said problem; as one, it is shaping the interregional cluster of alternative energy that is suggested by the authors. The leading approach to studying this problem is the systemic approach enabling an integrated view of the diverse elements (alternative energy, cluster approach, interregional interaction) that used to be considered individually. In the paper, the necessity of developing alternative energy is justified as one of the focus areas for ensuring Russia's sustainable environmental and economic development which requires the relevant material, labor and financial resources, technologies and equipment. In order to generate these, it is suggested to form the interregional cluster of alternative energy based on one of the four presented interregional interaction models, namely, the multilateral cross-sectoral model which is going to incorporate mutually associated sectors of the economy (producer sectors, supplier sectors, and consumer sectors) located in several regions and aimed at solving the shared problems. The materials of the paper are of practical value for the state and municipal authorities of Russia in terms of improving the policy implemented by them within sustainable development. Moreover, the results of the paper can be taken into account in forming an entire range of regulatory instruments and social and economic development programs for Russia in general and its regions in particular.
Keywords: Alternative energy; cluster approach; interregional cluster; region; cluster policy
JEL Classifications: C38, Q01, Q2, Q42
DOI: https://doi.org/10.32479/ijeep.795
Structured matrices, continued fractions, and root localization of polynomials
We give a detailed account of various connections between several classes of
objects: Hankel, Hurwitz, Toeplitz, Vandermonde and other structured matrices,
Stietjes and Jacobi-type continued fractions, Cauchy indices, moment problems,
total positivity, and root localization of univariate polynomials. Along with a
survey of many classical facts, we provide a number of new results.Comment: 79 pages; new material added to the Introductio
ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ Π°ΠΊΠ°Π΄Π΅Π·ΠΈΠ½Π° Π½Π° ΠΊΠ»Π΅ΡΠΊΠΈ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ
The riboside derivative acadesine (5-aminoimidazole-4-carboxamide-1-Ξ²-D-ribofuranoside) is currently being tested in clinical trialsΒ as a promising anti-tumor drug. Intracellular target of acadesine is adenosine monophosphate-activated protein kinase (ΠΠΠ Π), an importantΒ regulatory molecule of energy metabolism. It is expected that acadesine would be active in tumors under hypoxia conditions. In normoxia (cellsΒ incubated in 21 % oxygen), acadesine inhibited proliferation and induced cell death of breast adenocarcinoma, including the triple negativeΒ breast cancer line. When oxygen partial pressure was decreased to 1 % (experimental hypoxia), acadesine inhibited activation of reporterΒ construct responsive to HIF-1Ξ± (hypoxia inducible factor 1 alpha) transcription factor. This effect was observed for acadesineΒ in concentrations close to cytotoxic. Acadesine retained cytotoxicity under hypoxia and decreased the survival of the MDA-MB-231 cell lineΒ when used in combination with cisplatin. These results considerably widen acadesineβs field of application and allow to assume its efficacy inΒ chemotherapy combination regimens for breast cancer, including the tumors with low oxygenation.ΠΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΠΎΠ΅ ΡΠΈΠ±ΠΎΠ·ΠΈΠ΄Π° Π°ΠΊΠ°Π΄Π΅Π·ΠΈΠ½ (5βΠ°ΠΌΠΈΠ½ΠΎΠΈΠΌΠΈΠ΄Π°Π·ΠΎΠ»-4βΠΊΠ°ΡΠ±ΠΎΠΊΡΠ°ΠΌΠΈΠ΄-1βΞ²-D-ΡΠΈΠ±ΠΎΡΡΡΠ°Π½ΠΎΠ·ΠΈΠ΄) ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΠΏΡΡΠ°Π½ΠΈΡΒ ΠΊΠ°ΠΊ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ. ΠΠ½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½Π°Ρ ΠΌΠΈΡΠ΅Π½Ρ Π°ΠΊΠ°Π΄Π΅Π·ΠΈΠ½Π° Π°Π΄Π΅Π½ΠΎΠ·ΠΈΠ½ΠΌΠΎΠ½ΠΎΡΠΎΡΡΠ°Ρ-Π°ΠΊΡΠΈΠ²ΠΈΡΡΠ΅ΠΌΠ°ΡΒ ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΊΠΈΠ½Π°Π·Π° (ΠΠΠ Π, adenosine monophosphate-activated protein kinase) β Π²Π°ΠΆΠ½ΡΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ°.Β ΠΡΠ°Π²ΠΎΠΌΠ΅ΡΠ½ΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ, ΡΡΠΎ Π°ΠΊΠ°Π΄Π΅Π·ΠΈΠ½ ΠΎΠΊΠ°ΠΆΠ΅ΡΡΡ Π°ΠΊΡΠΈΠ²Π΅Π½ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ. Π Π½ΠΎΡΠΌΠΎΠΊΡΠΈΠΈ (ΠΈΠ½ΠΊΡΠ±Π°ΡΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² Π°ΡΠΌΠΎΡΡΠ΅ΡΠ΅ Ρ 21 % ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°) Π°ΠΊΠ°Π΄Π΅Π·ΠΈΠ½ Π²ΡΠ·ΡΠ²Π°Π» ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ ΠΈ Π³ΠΈΠ±Π΅Π»Ρ ΠΊΠ»Π΅ΡΠΎΠΊ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, Π² ΡΠΎΠΌΒ ΡΠΈΡΠ»Π΅ Π»ΠΈΠ½ΠΈΠΈ ΡΡΠΈΠΆΠ΄ΡΒ Π½Π΅Π³Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ°. ΠΡΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠΈ ΠΏΠ°ΡΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π΄Π°Π²Π»Π΅Π½ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° Π΄ΠΎ 1 % (ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ Π³ΠΈΠΏΠΎΠΊΡΠΈΡ)Β Π°ΠΊΠ°Π΄Π΅Π·ΠΈΠ½ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π» Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΏΡΠΎΠΌΠΎΡΠΎΡ-ΡΠ΅ΠΏΠΎΡΡΠ΅ΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΠΌ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ HIF-1Ξ±Β (hypoxia inducible factor 1 alpha). ΠΡΠΎΡ ΡΡΡΠ΅ΠΊΡ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈ ΠΏΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Π°ΠΊΠ°Π΄Π΅Π·ΠΈΠ½Π° Π² ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
, ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΡΡ
Ρ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ. ΠΠΊΠ°Π΄Π΅Π·ΠΈΠ½ ΡΠΎΡ
ΡΠ°Π½ΡΠ» ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π³ΠΈΠΏΠΎΠΊΡΠΈΠΈ ΠΈ ΡΠ½ΠΈΠΆΠ°Π» ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΡ Π³ΠΈΠΏΠΎΠΊΡΠΈΠ΅ΠΉ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊΒ Π»ΠΈΠ½ΠΈΠΈ MDA-MB-231 ΠΊ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΈΡΠΏΠ»Π°ΡΠΈΠ½Π°. ΠΡΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°ΡΡΠΈΡΡΡΡ ΠΎΠ±Π»Π°ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°ΠΊΠ°Π΄Π΅Π·ΠΈΠ½Π° ΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ Π΅Π³ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ΅ΠΆΠΈΠΌΠ°Ρ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π΄Π»Ρ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΎΠΊΡΠΈΠ³Π΅Π½Π°ΡΠΈΠ΅ΠΉ