Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones

Because of the beneficial effect of a trifluoromethyl group on the biological properties of bioactive compounds on the one hand and the versatile synthetic potential of beta-lactams on the other hand, 4-CF3-beta-lactams comprises interesting entities for the preparation of a large variety of CF3-substituted nitrogen-containing target structures with promising biological characteristics. In this review, we present an overview of different building block approach-based routes toward the synthesis of 4-(trifluoromethyl)azetidin-2-ones and the application of the "beta-lactam synthon method" for the synthesis of a diverse set of (a)cyclic CF3-substituted molecules by means of ring-opening and ring-transformation reactions

CAPACITY BUILDING FOR CIVIL SERVANTS AND STATE MANAGEMENT ORGANIZATIONS OF VIETNAM'S SEAS AND ISLANDS

Vietnam's seas and islands greatly influence political and legal life for national, regional, and international development in history, present, and future. The article analyzes the need and importance of capacity building for civil servants and state management organizations on seas and islands in the context of developing the marine economy and protecting Vietnam's sea and island sovereignty. With a long coastline and a rich island system, Vietnam is facing many challenges from resource exploitation, and climate change to national security and defense issues. The article discusses the current status of the sea and island management capacity of civil servants, officials, and related organizations, including limitations in expertise, management skills, and the ability to respond to complex situations. The article also proposes strategic solutions to improve management capacity through training, professional development, enhanced international cooperation, and application of modern technology in sea and island management. The article emphasizes that improving the capacity of civil servants and state management organizations is the key to effectively implementing policies for sustainable marine economic development and protecting national maritime interests, making an important contribution to the comprehensive development of Vietnam.  Article visualizations