Classifying visual field loss in glaucoma through baseline matching of stable reference sequences

Glaucoma is a common disease of the eye that often results in partial blindness. The main symptom of glaucoma is progressive loss of sight in the visual field over time. The clinical management of glaucoma involves monitoring the progress of the disease using a sequence of regular visual field tests. However, there is currently no universally accepted standard method for classifying changes in the visual field test data. Sequence matching techniques typically rely on similarity measures. However, visual field measurements are very noisy, particularly in people with glaucoma. It is therefore difficult to establish a reference data set including both stable and progressive visual fields. This paper proposes a method that uses a "baseline" computed from a query sequence, to match stable sequences in a database of visual field measurements collected from volunteers. The purpose of the new method is to classify a given query sequence as being stable or progressive. The results suggest that the new method gives a significant improvement in accuracy for identifying progressive sequences, though there is a small penalty for stable sequences

On crowdsourcing relevance magnitudes for information retrieval evaluation

4siMagnitude estimation is a psychophysical scaling technique for the measurement of sensation, where observers assign numbers to stimuli in response to their perceived intensity. We investigate the use of magnitude estimation for judging the relevance of documents for information retrieval evaluation, carrying out a large-scale user study across 18 TREC topics and collecting over 50,000 magnitude estimation judgments using crowdsourcing. Our analysis shows that magnitude estimation judgments can be reliably collected using crowdsourcing, are competitive in terms of assessor cost, and are, on average, rank-aligned with ordinal judgments made by expert relevance assessors. We explore the application of magnitude estimation for IR evaluation, calibrating two gain-based effectiveness metrics, nDCG and ERR, directly from user-reported perceptions of relevance. A comparison of TREC system effectiveness rankings based on binary, ordinal, and magnitude estimation relevance shows substantial variation; in particular, the top systems ranked using magnitude estimation and ordinal judgments differ substantially. Analysis of the magnitude estimation scores shows that this effect is due in part to varying perceptions of relevance: different users have different perceptions of the impact of relative differences in document relevance. These results have direct implications for IR evaluation, suggesting that current assumptions about a single view of relevance being sufficient to represent a population of users are unlikely to hold.partially_openopenMaddalena, Eddy; Mizzaro, Stefano; Scholer, Falk; Turpin, AndrewMaddalena, Eddy; Mizzaro, Stefano; Scholer, Falk; Turpin, Andre

Intermolecular interaction of photoexcited Cu(TMpy-P4) with water studied by transient resonance Raman and picosecond absorption spectroscopies

photoinduced complex between Cu(TMpy-P4) and water molecules, reversibly axially coordinated to the central metal, was observed in picosecond transient absorption and nanosecond resonance Raman experiments. This complex is rapidly created (τ1 = 15 ± 5 ps) in the excited triplet (π, π*) state of Cu-porphyrin, and the subsequent relaxation is proposed to proceed via two parallel pathways. One is fast and efficient (≥90% of molecules), and presumably involves a (π, d) charge-transfer state. The second pathway is slow (τ2 >> 1 ns), has a low quantum yield (≤10%) and involves the excited (d, d) state which is responsible for transient Raman features at ≈ 1553 cm−1 (ν2*) and ≈ 1347 cm−1 (ν4*), and for low-intensity long-lived transient absorption features

How to Use the Changing Components of the Corporate Annual Report

The amount of information required in a corporate annual report continues to increase. Most recently, additional reporting requirements brought about by the Sarbanes-Oxley Act of 2002 (SOA), the Public Company Accounting Oversight Board (PCAOB) and the Securities and Exchange Commission (SEC) increase the number of component reports that must be included in the annual report package. Lenders need to be familiar with the additional information that these new components provide. Therefore, this article summarizes the required component reports, discusses the information conveyed in each report and gives some examples of the types of significant new information that can be obtained

The Changing Components of the Corporate Annual Report: An Update

Recent regulatory changes affect not only the content of annual reports but also the population of companies that are required to comply with these reporting regulations. Lenders need to stay abreast of the information provided in corporate reporting packages. This article provides an update on regulatory changes and discusses how these changes affect the information that can be found in corporate annual reports

Conical refraction with low-coherence light sources

We report on conical refraction (CR) with low-coherence light sources, such as light-emitting diodes and decoherentized HeNe laser radiation, and demonstrate different CR patterns. In our experiments, a variation of the pinhole sizes from 25 to 100 µm and the distances to pinhole from 50 to 5 cm reduced spatial coherence of radiation that resulted in the disappearance of the dark Poggendorff’s ring in the Lloyd’s plane. This is attributed to the interference nature of the Lloyd’s distribution and found to be in excellent agreement with the paraxial dual-cone model of conical refraction

STLV-1 co-infection is correlated with an increased SFV proviral load in the peripheral blood of SFV/STLV-1 naturally infected non-human primates

Simian T-Leukemia Virus type 1 and Simian Foamy Virus infect non-human primates. While STLV-1, as HTLV-1, causes Adult T-cell Leukemia/lymphoma, SFV infection is asymptomatic. Both retroviruses can be transmitted from NHPs to humans through bites that allow contact between infected saliva and recipient blood. Because both viruses infect CD4+ T-cells, they might interfere with each other replication, and this might impact viral transmission. Impact of STLV-1 co-infection on SFV replication was analyzed in 18 SFV-positive/STLV-1-negative and 18 naturally SFV/STLV-1 co-infected Papio anubis. Even if 9 animals were found STLV-1-positive in saliva, STLV-1 PVL was much higher in the blood. SFV proviruses were detected in the saliva of all animals. Interestingly, SFV proviral load was much higher in the blood of STLV-1/SFV co-infected animals, compared to STLV-1-negative animals. Given that soluble Tax protein can enter uninfected cells, we tested its effect on foamy virus promoter and we show that Tax protein can transactivate the foamy LTR. This demonstrates that true STLV-1 co-infection or Tax only has an impact on SFV replication and may influence the ability of the virus to be zoonotically transmitted as well as its ability to promote hematological abnormalities