Instability of computer vision models is a necessary result of the task itself

Adversarial examples resulting from instability of current computer vision models are an extremely important topic due to their potential to compromise any application. In this paper we demonstrate that instability is inevitable due to a) symmetries (translational invariance) of the data, b) the categorical nature of the classification task, and c) the fundamental discrepancy of classifying images as objects themselves. The issue is further exacerbated by non-exhaustive labelling of the training data. Therefore we conclude that instability is a necessary result of how the problem of computer vision is currently formulated. While the problem cannot be eliminated, through the analysis of the causes, we have arrived at ways how it can be partially alleviated. These include i) increasing the resolution of images, ii) providing contextual information for the image, iii) exhaustive labelling of training data, and iv) preventing attackers from frequent access to the computer vision system

A study of balance and gait following stroke : implications for rehabilitation

This study examined: the features and extent of the gait velocity decrement following stroke; the nature of the balance disorder and; investigated relationships between gait and balance. Twenty, fully-ambulant, hemiplegic subjects (12 men and 8 women), with a mean age of 57.2 years (± 10.7), were compared with 20 age- and sex-matched controls. Spatiotemporal gait kinematics were measured at five walking speeds ranging from "very slow" to "very fast". Balance was then measured while subjects maintained a variety of weight shift postures both with feet parallel and then in diagonal positions similar to those assumed during the double support phases of gait. Location and variability of centre of pressure (CP) were measured and the ranges over which CP could be shifted were calculated. Stroke subjects walked very slowly with their "fastest" walking speed (0.5 stat/s ± 0.23) no different from the "slowest" speed (0.38 stat/s ± 0.11) of the controls (p > 0.05). Differences between the other parameters were also found, many of which could be attributed to the differences in walking speeds. However, where the subjects walked at similar velocities, the hemiplegic sample walked with quicker and shoner strides suggesting a "cautious" gait pattern. The single support asymmetry of the strokes decreased with increasing walking speed. The positions of CP in the hemiplegic sample were found to be significantly displaced towards the unaffected leg and deficiencies were found in posterior shifts (p < 0.05). Postural sway was significantly greater in the hemiplegic sample implying less stable balance and the ranges over which the hemiplegic sample shifted weight were significantly less than the controls. The diagonal weight shift tests revealed the difficulty the stroke subjects experienced in shifting CP posterolaterally over the affected leg. Significant correlations were detected confmning the presence of relationships between static balance performance and gait. However, these correlation findings left considerable percentages of variance unexplained. These findings suggest that future rehabilitation should address the poverty of range of walking speed possessed by hemiplegic subjects as well as the reduced ability to weight shift over the hemiplegic limb, particularly posterolaterally. Further study to test these proposals is indicated

Extragenic suppressor mutations that restore twitching motility to fimL mutants of Pseudomonas aeruginosa are associated with elevated intracellular cyclic AMP levels

Cyclic AMP (cAMP) is a signaling molecule that is involved in the regulation of multiple virulence systems of the opportunistic pathogen Pseudomonas aeruginosa. The intracellular concentration of cAMP in P. aeruginosa cells is tightly controlled at the levels of cAMP synthesis and degradation through regulation of the activity and/or expression of the adenylate cyclases CyaA and CyaB or the cAMP phosphodiesterase CpdA. Interestingly, mutants of fimL, which usually demonstrate defective twitching motility, frequently revert to a wild-type twitching-motility phenotype presumably via the acquisition of an extragenic suppressor mutation(s). In this study, we have characterized five independent fimL twitching-motility revertants and have determined that all have increased intracellular cAMP levels compared with the parent fimL mutant. Whole-genome sequencing revealed that only one of these fimL revertants has acquired a loss-of-function mutation in cpdA that accounts for the elevated levels of intracellular cAMP. As mutation of cpdA did not account for the restoration of twitching motility observed in the other four fimL revertants, these observations suggest that there is at least another, as yet unidentified, site of extragenic suppressor mutation that can cause phenotypic reversion in fimL mutants and modulation of intracellular cAMP levels of P. aeruginosa

Walking with Music Is a Safe and Viable Tool for Gait Training in Parkinson's Disease: The Effect of a 13-Week Feasibility Study on Single and Dual Task Walking

This study explored the viability and efficacy of integrating cadence-matched, salient music into a walking intervention for patients with Parkinson's disease (PD). Twenty-two people with PD were randomised to a control (CTRL, n = 11) or experimental (MUSIC, n = 11) group. MUSIC subjects walked with an individualised music playlist three times a week for the intervention period. Playlists were designed to meet subject's musical preferences. In addition, the tempo of the music closely matched (±10–15 bpm) the subject's preferred cadence. CTRL subjects continued with their regular activities during the intervention. The effects of training accompanied by “walking songs” were evaluated using objective measures of gait score. The MUSIC group improved gait velocity, stride time, cadence, and motor symptom severity following the intervention. This is the first study to demonstrate that music listening can be safely implemented amongst PD patients during home exercise

Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human immunodeficiency virus type 1 infection

<p>Abstract</p> <p>Background</p> <p>CD8+ T cells play an important role in control of viral replication during acute and early human immunodeficiency virus type 1 (HIV-1) infection, contributing to containment of the acute viral burst and establishment of the prognostically-important persisting viral load. Understanding mechanisms that impair CD8+ T cell-mediated control of HIV replication in primary infection is thus of importance. This study addressed the relative extent to which HIV-specific T cell responses are impacted by viral mutational escape versus reduction in response avidity during the first year of infection.</p> <p>Results</p> <p>18 patients presenting with symptomatic primary HIV-1 infection, most of whom subsequently established moderate-high persisting viral loads, were studied. HIV-specific T cell responses were mapped in each individual and responses to a subset of optimally-defined CD8+ T cell epitopes were followed from acute infection onwards to determine whether they were escaped or declined in avidity over time. During the first year of infection, sequence variation occurred in/around 26/33 epitopes studied (79%). In 82% of cases of intra-epitopic sequence variation, the mutation was confirmed to confer escape, although T cell responses were subsequently expanded to variant sequences in some cases. In contrast, < 10% of responses to index sequence epitopes declined in functional avidity over the same time-frame, and a similar proportion of responses actually exhibited an increase in functional avidity during this period.</p> <p>Conclusions</p> <p>Escape appears to constitute a much more important means of viral evasion of CD8+ T cell responses in acute and early HIV infection than decline in functional avidity of epitope-specific T cells. These findings support the design of vaccines to elicit T cell responses that are difficult for the virus to escape.</p

Eighteenth annual report of the Power Affiliates Program.

Includes bibliographical references