A Rare Coronary Artery Anomaly Presented With Acute Myocardial Infarction in a Young Patient

Single coronary artery (SCA) anomaly is a rare angiographic finding and majority of the patients are asymptomatic; however, myocardial ischemia and sudden death have been reported. We report a 26 year old male patient with SCA with acute myocardial infarction, in whom successful coronary angioplasty was performed to the left anterior descending artery through an anomalous of the right coronary artery, originating from the proximal part of the circumflex coronary artery. The patient was discharged with uneventful recovery

Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular Diseases

Recently, muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases. Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines, especially irisin. Irisin is a polypeptide hormone consisting of 112 amino acids secreted into the blood from muscle and adipose tissues. Serum irisin levels are associated with cardiometabolic risk factors such as obesity and insulin resistance as defined by homeostatic model assessment. Irisin reduces endothelial damage by inhibiting inflammation and oxidative stress, thus playing a key role in maintaining endothelial cell function. Unsurprisingly, low irisin levels cause endothelial dysfunction and increase the incidence of atherosclerosis. We aimed to summarize the studies on this issue since we have not found any review in the literature on the role of serum irisin levels in the process of atherosclerosis and other cardiovascular events in cardiovascular diseases

A New and Eco-Friendly Method for Reduction of Ketones in Water

WOS: 000477963800024This paper reports a new, practical, and environmentally friendly catalytic system for reduction of the ketones to the related alcohols with efficient reaction performance in water. Catalysts were generated in situ from rhodium, ruthenium and iridium transition metal compounds with commercially available piperidines [Piperidine (L-1), 2-hydroxymethylpiperidine (L-2), 3-hydroxymethylpiperidine (L-3), 4-hydroxymethylpiperidine (L-4), 4-hydroxypiperidine (L-5)] as bifunctional ligands. Catalyst generated from RuCl2(PPh3)(3) and 4-hydroxymethyl piperidine have shown the best activity in aqueous media which gave a 100% product yield. RuCl2(PPh3)(3), has showed a better efficiency than [RuCl2(p-cymene)](2), IrCl(PPh3)(3), or RhCl(PPh3)(3) in HCOOH-HCOONa buffer solution. This study was also investigated the relationship between the structure of hydroxymethyl piperidine ligands and the catalytic activity

Associations between Vaspin Levels and Coronary Artery Disease

The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers. Although adipokine concentrations have been shown to be increased significantly in atherosclerotic lesions, the role adipokines in the atherosclerotic process remains to be elucidated. Vaspin is a new biological marker associated with obesity and impaired insulin sensitivity. Plasma vaspin concentration has been shown to correlate with the severity of coronary artery disease. Vascular inflammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation. Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio. The therapeutic goal concerning vaspin is to fight atherosclerosis and related diseases, as well as to maintain vascular health

Comparison of Foliar Anatomy of Scorzonera L. (Asteraceae) Taxa from North East Anatolia

Coskuncelebi, Kamil/0000-0001-5713-6628;WOS: 000288090700015In the present study, the leaves of 18 Scorzonera L. (Asteraceae) taxa were studied by LM in order to assess anatomical variations that may serve as distinguishing characters and to evaluate their significance for the genus by numerical analysis. All the investigated species can be divided into distinct groups according to mesophyll and midrib structure. Firstly they can be divided in two groups based on presence/absence of cavity on midrib. Secondarily two main vascular bundle types can be identified in transverse sections according to the presence or absence of secretory cells in phloem. Principal component analysis (PCA) showed that width of the palisade tissue beneath the upper epidermis, rate of spongy to the mesophyll (w/w), average number of epidermal cells for both sides and average number of stomata on upper side are the most important characters in explaining the total variations

Ecstasy Intake Related Coagulopathy

3,4-methylenedioxymethamphetamine (MDMA), substance known as "Ecstasy" among the people and used due to entertainment, euphoric and energy booster effect, is one of the famous synthetic stimulants.  22-year-old man was found as unconscious in the early morning. According to the expressions of his family and friends, it was learned that he drank alcohol until late in the previous evening and took ecstasy besides this before he died. It was reported that he was taken to intensive care unit with temperature of 41oC and death occurred 12 hours later. At autopsy in external examination, petechial and purpuric hemorrhages in purple and red color were detected on body. In internal examination, petechial hemorrhages on the surface of the heart and lungs, subendocardial hemorrhage in the heart, hemorrhage on the mucosal surface of the stomach were seen. In the toxicological analyses of the blood, Paracetamol (4870 ng/ml), MDMA (847 ng/ml), MDA (94,2 ng/ml), Lidocaine (23 ng/ml), Pantoprazole (10,5 ng/ml), Midazolam (1,83 ng/ml) were detected. The death occurred due to coagulopathy related MDMA intoxication. Here, we present a case of autopsy, clinical findings and histopathologic findings, laboratory results in medicolegal literature

Piano-stool Ru (II) arene complexes that contain ethylenediamine and application in alpha-alkylation reaction of ketones with alcohols

WOS: 000465346500010A series of piano-stool Ru (II) complexes (Ru1-7) bearing ethylenediamine with aryl and aliphatic groups were prepared and fully characterized by H-1, C-13, F-19 and P-31 NMR spectroscopy, FT-IR and elemental analysis. The crystal structures of Ru2-4 and Ru-7 were determined by X-ray crystallography. They were successfully applied to the alpha(alpha)-alkylation of aliphatic and aromatic ketones with alcohols via the borrowing hydrogen strategy in mild reaction conditions within a short time. The catalytic system has a broad substrate scope, which allows the synthesis of alpha alkylated ketones with excellent yields. The electronic and steric effects of complexes on catalytic activity were analysed. The influence of the carbon chain length of the ligand on the alpha-alkylation reaction of ketones was also investigated. The catalytic cycle was also examined by H-1-NMR spectroscopy in d(8)-toluene.Ege University and Scientific and Technological Research Council of Turkey (TUBITAK) [214Z098]The authors thank Ege University and Scientific and Technological Research Council of Turkey (TUBITAK, Project Number: 214Z098) for the financial support. The authors acknowledge Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8 QUEST diffractometer