Orbital operations study. Volume 2: Interfacing activities analyses. Part 3: Data management activity group

A summary of the findings of the data management group of the orbital operations study is presented. Element interfaces, alternate approaches, design concepts, operational procedures, functional requirements, design influences, and approach selection are described. The following interfacing activities are considered: (1) communications, (2) rendezvous, (3) stationkeeping, and (4) detached element operations

Multigrid for hypersonic inviscid flows

The use of multigrid methods to solve the Euler equations for hypersonic flow is discussed. The steady state equations are considered with a Runge-Kutta smoother based on the time accurate equations together with local time stepping and residual smoothing. The effect of the Runge-Kutta coefficients on the convergence rate was examined considering both damping characteristics and convection properties. The importance of boundary conditions on the convergence rate for hypersonic flow is discussed. Also of importance are the switch between the second and fourth difference viscosity. Solutions are given for flow around the bump in a channel and flow around a biconic section

Orbital operations study. Appendix B: Operational procedures

Operational procedures for each alternate approach for each interfacing activity of the orbital operations study are presented. The applicability of the procedures to interfacing element pairs is identified

Botulinum toxin type A in the prophylactic treatment of chronic tension-type headache: A multicentre, double-blind, randomized, placebo-controlled, parallel-group study

We studied the safety and efficacy of 0 U, 50 U, 100 U, 150 U (five sites), 86 Usub and 100 Usub (three sites) botulinum toxin type A (BoNTA; BOTOX); Allergan, Inc., Irvine, CA, USA) for the prophylaxis of chronic tension-type headache (CTTH). Three hundred patients (62.3% female; mean age 42.6 years) enrolled. For the primary endpoint, the mean change from baseline in the number of TTH-free days per month, there was no statistically significant difference between placebo and four BoNTA groups, but a significant difference favouring placebo vs. BoNTA 150 was observed (4.5 vs. 2.8 tension headache-free days/month; P = 0.007). All treatment groups improved at day 60. Although efficacy was not demonstrated for the primary endpoint, at day 90, more patients in three BoNTA groups had \u3eor=50% decrease in tension headache days than did placebo (

A Scheme to Numerically Evolve Data for the Conformal Einstein Equation

This is the second paper in a series describing a numerical implementation of the conformal Einstein equation. This paper deals with the technical details of the numerical code used to perform numerical time evolutions from a "minimal" set of data. We outline the numerical construction of a complete set of data for our equations from a minimal set of data. The second and the fourth order discretisations, which are used for the construction of the complete data set and for the numerical integration of the time evolution equations, are described and their efficiencies are compared. By using the fourth order scheme we reduce our computer resource requirements --- with respect to memory as well as computation time --- by at least two orders of magnitude as compared to the second order scheme.Comment: 20 pages, 12 figure

Treatment of Adult Spasticity With Botox (onabotulinumtoxinA): Development, Insights, and Impact

Upper and lower limb spasticity (ULS, LLS) often occur following a stroke or in patients with other neurological disorders, leading to difficulties in mobility and daily living and decreased quality of life. Prior to the use of onabotulinumtoxinA, antispastic medications had limited efficacy and often caused sedation. Phenol injections were difficult for physicians to perform, painful, and led to tissue destruction. The success of onabotulinumtoxinA in treating cervical dystonia led to its use in spasticity. However, many challenges characterized the development of onabotulinumtoxinA for adult spasticity. The wide variability in the presentation of spasticity among patients rendered it difficult to determine which muscles to inject and how to measure improvement. Another challenge was the initial refusal of the Food and Drug Administration to accept the Ashworth Scale as a primary endpoint. Additional scales were designed to incorporate a goal-oriented, patient-centered approach that also accounted for the variability of spasticity presentations. Several randomized, double-blind, placebo-controlled trials of post-stroke spasticity of the elbow, wrist, and/or fingers showed significantly greater improvements in the modified Ashworth Scale and patient treatment goals and led to the approval of onabotulinumtoxinA for the treatment of ULS in adult patients. Lessons learned from the successful ULS trials were applied to design an LLS trial that led to approval for the latter indication. Additional observational trials mimicking real-world treatment have shown continued effectiveness and patient satisfaction. The use of onabotulinumtoxinA for spasticity has ushered in a more patient-centered treatment approach that has vastly improved patients\u27 quality of life

Nonfatal Strangulation in a Sample of Domestically Violent Stalkers: The Importance of Recognizing Coercively Controlling Behaviors

© 2019 International Association for Correctional and Forensic Psychology. Strangulation is different to other types of physical violence as it often leaves no visible injuries and is frequently motivated by coercive control. Few studies have explored nonfatal strangulation and coercive control, and no studies have explored these factors within a sample of stalkers. Given that stalking perpetrators exhibit many of the coercively controlling behaviors related to nonfatal strangulation, the current study explored nonfatal strangulation and other coercively controlling behaviors in a stalking sample. A police dataset of 9,884 cases of domestic violence that involved stalking was analyzed. Results revealed that coercive control and related behaviors of excessive jealousy, victim isolation, victim fear, and victim’s belief that the perpetrator will kill them were associated with higher likelihood of having experienced nonfatal strangulation. These results may help first responders to identify victims at risk of nonfatal strangulation and suggest a need for nonfatal strangulation to be a criminal offense

Analysis of preconditioning and multigrid for Euler flows with low-subsonic regions

For subsonic flows and upwind-discretized, linearized 1-D Euler equations, the smoothing behavior of multigrid-accelerated point Gauss-Seidel relaxation is analyzed. Error decay by convection across domain boundaries is also discussed. A fix to poor convergence rates at low Mach numbers is sought in replacing the point relaxation applied to unconditioned Euler equations, by locally implicit “time”-stepping applied to preconditioned Euler equations. The locally implicit iteration step is optimized for good damping of high-frequency errors. Numerical inaccuracy at low Mach numbers is also addressed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41714/1/10444_2005_Article_BF02123476.pd

Impact of Rheumatic Musculoskeletal Disease on Psychological Development in Adolescents and Young Adults

Adolescents and young adults (AYAs) undergo significant physiological and psychological transformations. When developmental milestones are combined with additional challenges of growing up with a chronic rheumatic musculoskeletal disease (RMD), it can increase AYA's susceptibility to psychological problems. Emotional issues in adolescence can often persist into adulthood and negatively impact future health, social, and work outcomes. This chapter summarises psychological challenges for AYAs and recommends ways for healthcare professionals (HCPs) to promote mental wellbeing in AYAs with RMD

Long-Term Blocking of Calcium Channels in mdx Mice Results in Differential Effects on Heart and Skeletal Muscle

The disease mechanisms underlying dystrophin-deficient muscular dystrophy are complex, involving not only muscle membrane fragility, but also dysregulated calcium homeostasis. Specifically, it has been proposed that calcium channels directly initiate a cascade of pathological events by allowing calcium ions to enter the cell. The objective of this study was to investigate the effect of chronically blocking calcium channels with the aminoglycoside antibiotic streptomycin from onset of disease in the mdx mouse model of Duchenne muscular dystrophy (DMD)