Non-Valvuler Atriyal Fibrilasyonu Olan Hastalarda Kanama Risk Sınıflandırılmasında Platelet-Lenfosit Oranının Yeni Kullanımları: Pilot Çalışma

Objective: The primary aim of this study was to investigate the role of platelet-lymphocyte ratio (PLR) to predict bleeding risk in nonvalvular atrial fibrillation (NVAF). Secondary aim was to determine the possible relation between PLR and thromboembolic and bleeding risk scores. Tertiary aim was to evaluate the predictive value of PLR for the patients in the therapeutic international normalized ratio (INR) range. Method: PLR was calculated from the complete blood count of 228 patients who were under warfarin management for NVAF. The patients were called and it was questioned whether they had experienced the bleeding event within six months after measurement of the PLR values. Correspondence/Yazışma Adresi: Kahraman Cosansu, Deparment of Cardiology, Sakarya University, Education and Research Hospital Sakarya, Turkey, 54100 e-mail: [email protected] DOI: 10.5798/dicletip.705814 Results: Bleeding event was observed in 48 patients after the PLR was calculated. It was found significantly correlation between PLR and CHA2DVAS2C (p165,9 was determined significant indicator for bleeding (p 165,9 değeri kanama için önemli bir gösterge olarak belirlendi (p <0.001) ve 12 kattan fazla kanama riski olduğunu gösterdi (12.27, [5.74-26.21]). Sonuç: Bu çalışmanın sonuçları PLR'nin kanama riskini saptamak için yararlı bir parametre olabileceğini göstermektedir. Bildiğimiz kadarıyla, bu PLR'nin hem CHA2DS2-VASc hem de HAS-BLED risk skorları ile korelasyonunu gösteren ilk çalışmadır. PLR ayrıca terapötik INR aralığındaki hastaları da öngörebilir

Short-term effects of sleeve gastrectomy on weight loss and diastolic function in obese patients

Objective: Bariatric surgery has been shown to improve cardiac structure and function in obese patients. This study was an examination of the short-term effects of sleeve gastrectomy on body measurements and diastolic function

Doppler Tissue Evaluation of Atrial Conduction Properties in Patients With Non-alcoholic Fatty-liver Disease

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in clinical practice, and there is an increasing trend in its prevalence in the general population. Recent studies have demonstrated increased risk of atrial fibrillation (AF) in NAFLD. However, information on the mechanism of increased risk of AF in NAFLD is lacking. Impaired atrial conduction is an important factor in the pathophysiology of AF. We aimed to investigate atrial conduction properties in patients with NAFLD by tissue Doppler echocardiography. Fifty-nine ultrasound diagnosed NAFLD patients without clinical diagnosis of hypertension, diabetes mellitus, or cardiac disease and 22 normal subjects as controls were included in this study. Atrial conduction properties were assessed by electromechanical delay (EMD) derived from Doppler tissue echocardiography examination and P-wave dispersion (PWD) calculated from the 12-lead electrocardiogram. Inter-atrial and intra-atrial EMD intervals were significantly longer in NAFLD patients than in controls (inter-atrial EMD, 31.9 +/- 8.5 ms vs. 23.4 +/- 4.6 ms, p = 0.0001, and intra-atrial EMD, 14.3 +/- 5.2 vs. 10.2 +/- 4.0 ms, p = 0.001). Similarly, PWD was significantly higher in NAFLD patients compared with controls (49.2 +/- 6.3 ms vs. 43.3 +/- 4.2 ms, p = 0.0001). Maximum left atrial volume was also significantly higher in the NAFLD group than in controls (51 +/- 11 mL vs. 34 +/- 9 mL, p < 0.0001). This study demonstrated that atrial conduction is impaired in patients with NAFLD. Also, in a patient population of NAFLD without any clinical diagnosis of cardiac disease, diabetes, or hypertension, left atrial volume was increased compared with controls. These findings suggest impaired atrial conduction as a factor in increased risk of AF in NAFLD