Cinema Komunisto: cinema as a memory site

Cinema Komunisto is a documentary film about the use of the cinematic image in the creation of the political narrative of socialist Yugoslavia, taking as its starting point an abandoned film studio that had once been the crown-jewel of the Yugoslav film industry. An intensive five-year research process resulted in a story told through a montage of clips from fiction films and exclusive documentary archive, interspersed with interviews with key filmmakers, actors and studio bosses, as well as President Tito’s personal projectionist. In the introduction, a brief historical overview establishes the central position of cinema in socialist Yugoslavia, its contribution to the ‘imagined community’ in it’s articulation of political myths and the narration of the common past. Transitioning over to the present-day, the commemorative function of cinema is discussed in the context of post-war and post-socialist public discourse. A theoretical analysis of the relationship between cinema and history follows.Beginning with the concerns over the use of cinema as historical document, it extends to challenges faced by filmmakers seeking to ‘revision’ the past (Rosenstone, 2006)through the making of historical films. Starting with the Annales historians, such as Marc Ferro, and their contribution to the liberation of film from the requirements of written historiography, the argument is made for separating visual historical discourse from historical evidence (Ernest, 1983) and the challenge of making films with cinematic language (de Baecque, 2008)) is taken on. The final theoretical section discusses the impact of the ‘memory turn’ on the meeting between cinema and history, and argues for adopting the key concepts of cultural memory, such as it’s present-day operation, instrumentality and mediality as useful tools for this inquiry. Pierre Nora’s concept of lieux de mémoire proves fundamental as an analytical tool of the analysis of films as ‘memory sites’. The memory turn is then situated within the context of postsocialist societies, such as Yugoslavia, where films become a useful means ofrepresenting the ‘transition of meanings’ taking place. Adopting the concepts of Robert Rosenstone, the next section responds to the challenge of developing ‘rules of engagement’ that would allow for a particular ‘historical understanding.’ By situating Cinema Komunisto within the tradition of refractive cinema (Corrigan, 2011), particularly the use of cinema as an expression of history (Godard’s Histoire(s) du cinéma) or of history written by decree (Marker’s The Last Bolshevik), I set out to assess and build on aesthetic and philosophical concepts developed by Marker and Godard. Closer to home, inspiration is drawn from filmmaker Dušan Makavejev and his approach of developing ‘theory in practice’ in Innocence Unprotected. The elaboration of rules of engagement involves re-working the visual material, including the free mixing of documentary archive and clips from feature films, decontextualising and interrogation of images. Use of concepts such as that of intentional disparity (Baron, 20014) allows the subversion of the intended use of images. Thesection on narrative voice questions the establishing of the right critical distance and subjective positioning of the author as narrator. Following the decisions to eschew an all-knowing voice-over, and to rely on character-narration, the editing approach becomes vital. Montage allows the elaboration of a philosophical approach, invoking Benjamin’s concept of the dialectic image land the rapprochement of historical fragments to provoke critical reflection. Finally, temporal disunity and spatial articulation are discussed as narrative strategies. Temporal non-linearity and parallels in the dramaturgy add the ability to chart transitioning historical meanings into the present-day, tying back to concepts of social memory as the traces of the past in the present. Spatial narration is discussed in light of situated testimonies in geographical lieux de memoire, and the narrative and symbolic meaning of ruins, as markers of social forgetting. Both strategies prove to be valuable as ‘rules of engagement’, in particular because of the political dimension of constructing memory texts. In conclusion it is argued that the historical understanding achieved by the adoption of the discussed ‘rules of engagement’ achieves a reconciliation of subjective truth and intimate lyricism, with the philosophical and pedagogical aim of a critical reflection on conventional historical narration. As a memory text, Cinema Komunisto positions memory before historical truth, and ultimately managing to find meaning in ruins

A novel framework for high-quality voice source analysis and synthesis

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The analysis, parameterization and modeling of voice source estimates obtained via inverse filtering of recorded speech are some of the most challenging areas of speech processing owing to the fact humans produce a wide range of voice source realizations and that the voice source estimates commonly contain artifacts due to the non-linear time-varying source-filter coupling. Currently, the most widely adopted representation of voice source signal is Liljencrants-Fant's (LF) model which was developed in late 1985. Due to the overly simplistic interpretation of voice source dynamics, LF model can not represent the fine temporal structure of glottal flow derivative realizations nor can it carry the sufficient spectral richness to facilitate a truly natural sounding speech synthesis. In this thesis we have introduced Characteristic Glottal Pulse Waveform Parameterization and Modeling (CGPWPM) which constitutes an entirely novel framework for voice source analysis, parameterization and reconstruction. In comparative evaluation of CGPWPM and LF model we have demonstrated that the proposed method is able to preserve higher levels of speaker dependant information from the voice source estimates and realize a more natural sounding speech synthesis. In general, we have shown that CGPWPM-based speech synthesis rates highly on the scale of absolute perceptual acceptability and that speech signals are faithfully reconstructed on consistent basis, across speakers, gender. We have applied CGPWPM to voice quality profiling and text-independent voice quality conversion method. The proposed voice conversion method is able to achieve the desired perceptual effects and the modified speech remained as natural sounding and intelligible as natural speech. In this thesis, we have also developed an optimal wavelet thresholding strategy for voice source signals which is able to suppress aspiration noise and still retain both the slow and the rapid variations in the voice source estimate

Qualifikationsprobleme in Doppelbesteuerungsabkommen unter Berücksichtigung des Art. 15 Abs. 1 und 2 OECD-Musterabkommen

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cyTRON and cyTRON/JS: two Cytoscape-based applications for the inference of cancer evolution models

The increasing availability of sequencing data of cancer samples is fueling the development of algorithmic strategies to investigate tumor heterogeneity and infer reliable models of cancer evolution. We here build up on previous works on cancer progression inference from genomic alteration data, to deliver two distinct Cytoscape-based applications, which allow to produce, visualize and manipulate cancer evolution models, also by interacting with public genomic and proteomics databases. In particular, we here introduce cyTRON, a stand-alone Cytoscape app, and cyTRON/JS, a web application which employs the functionalities of Cytoscape/JS. cyTRON was developed in Java; the code is available at https://github.com/BIMIB-DISCo/cyTRON and on the Cytoscape App Store http://apps.cytoscape.org/apps/cytron. cyTRON/JS was developed in JavaScript and R; the source code of the tool is available at https://github.com/BIMIB-DISCo/cyTRON-js and the tool is accessible from https://bimib.disco.unimib.it/cytronjs/welcome

A novel framework for high-quality voice source analysis and synthesis

The analysis, parameterization and modeling of voice source estimates obtained via inverse filtering of recorded speech are some of the most challenging areas of speech processing owing to the fact humans produce a wide range of voice source realizations and that the voice source estimates commonly contain artifacts due to the non-linear time-varying source-filter coupling. Currently, the most widely adopted representation of voice source signal is Liljencrants-Fant's (LF) model which was developed in late 1985. Due to the overly simplistic interpretation of voice source dynamics, LF model can not represent the fine temporal structure of glottal flow derivative realizations nor can it carry the sufficient spectral richness to facilitate a truly natural sounding speech synthesis. In this thesis we have introduced Characteristic Glottal Pulse Waveform Parameterization and Modeling (CGPWPM) which constitutes an entirely novel framework for voice source analysis, parameterization and reconstruction. In comparative evaluation of CGPWPM and LF model we have demonstrated that the proposed method is able to preserve higher levels of speaker dependant information from the voice source estimates and realize a more natural sounding speech synthesis. In general, we have shown that CGPWPM-based speech synthesis rates highly on the scale of absolute perceptual acceptability and that speech signals are faithfully reconstructed on consistent basis, across speakers, gender. We have applied CGPWPM to voice quality profiling and text-independent voice quality conversion method. The proposed voice conversion method is able to achieve the desired perceptual effects and the modified speech remained as natural sounding and intelligible as natural speech. In this thesis, we have also developed an optimal wavelet thresholding strategy for voice source signals which is able to suppress aspiration noise and still retain both the slow and the rapid variations in the voice source estimate.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Kidney cancer: The next decade

Chris Boshoff, Senior Vice President of Immuno-Oncology, Translational and Early Development at Pfizer, and colleagues Samra Turajlic and Charles Swanton from the Francis Crick Institute and University College London give us their personal point of view on new insights and future therapeutic approaches for renal cancer

An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Purpose The immune checkpoint inhibitors (ICIs) have resulted in subgroups of patients with metastatic melanoma achievinghigh-quality durable responses. Metastatic melanoma survivors are a new population in the era of cancer survivorship. The aimofthis study was to evaluate metastatic melanoma survivors in terms of health-related quality of life (HRQoL), immune-relatedadverse events (irAEs) and exposure to immunosuppressive agents in a large single centre in the UK.Methods We defined the survivor population as patients with a diagnosis of metastatic melanoma who achieved a durableresponse to an ICI and had been followed-up for a minimum of 12 months from initiation of ICI without disease progression.HRQoL was assessed using SF-36. Electronic health records were accessed to collect data on demographics, treatments, irAEsand survival. HRQoL data was compared with two norm-based datasets.Results Eighty-four metastatic melanoma survivors were eligible and 87% (N = 73) completed the SF-36. ICI-related toxicity ofany grade occurred in 92%of patients and 43%had experienced a grade 3 or 4 toxicity. Almost half (49%) of the patients requiredsteroids for the treatment of ICI-related toxicity, whilst 14% required treatment with an immunosuppressive agent beyondsteroids.Melanoma survivors had statistically significant lower HRQoL scores with regard to physical, social and physical rolefunctioning and general health compared with the normative population. There was a trend towards inferior scores in patientswith previous exposure to ipilimumab compared with those never exposed to ipilimumab.Conclusions Our results show that metastatic melanoma survivors have potentially experienced significant ICI-related toxicityand experience significant impairments in specific HRQoL domains. Future service planning is required to meet this population’sunique survivorship needs.Peer reviewe

Tracking Cancer Evolution through the Disease Course.

During cancer evolution, constituent tumor cells compete under dynamic selection pressures. Phenotypic variation can be observed as intratumor heterogeneity, which is propagated by genome instability leading to mutations, somatic copy-number alterations, and epigenomic changes. TRACERx was set up in 2014 to observe the relationship between intratumor heterogeneity and patient outcome. By integrating multiregion sequencing of primary tumors with longitudinal sampling of a prospectively recruited patient cohort, cancer evolution can be tracked from early- to late-stage disease and through therapy. Here we review some of the key features of the studies and look to the future of the field. SIGNIFICANCE: Cancers evolve and adapt to environmental challenges such as immune surveillance and treatment pressures. The TRACERx studies track cancer evolution in a clinical setting, through primary disease to recurrence. Through multiregion and longitudinal sampling, evolutionary processes have been detailed in the tumor and the immune microenvironment in non-small cell lung cancer and clear-cell renal cell carcinoma. TRACERx has revealed the potential therapeutic utility of targeting clonal neoantigens and ctDNA detection in the adjuvant setting as a minimal residual disease detection tool primed for translation into clinical trials