Exploring Effective Methods for Simulating Damaged Structures with Geometric Variation: toward Intelligent Failure Detection

Inaccuracies in the modeling assumptions about the distributional characteristics of the monitored signatures have been shown to cause frequent false positives in vehicle monitoring systems for high-risk aerospace applications. to enable the development of robust fault detection methods, this work explores the deterministic as well as variational characteristics of failure signatures. Specifically, we explore the combined impact of crack damage and manufacturing variation on the vibrational characteristics of beams. the transverse vibration and associated eigenfrequencies of the beams are considered. Two different approaches are used to model beam vibrations with and without crack damage. the first approach uses a finite difference approach to enable the inclusion of both cracks and manufacturing variation. the crack model used with both approaches is based on a localized decrease in the Young\u27s modulus. the second approach uses Myklestad\u27s method to evaluate the effects of cracks and manufacturing variation. using both beam models, Monte Carlo simulations are used to explore the impacts of manufacturing variation on damaged and undamaged beams. Derivations are presented for both models. Conclusions are presented on the choice of modeling techniques to define crack damage, and its impact on the monitored signal, followed by conclusions about the distributional characteristics of the monitored signatures when exposed to random manufacturing variations. Copyright © 2007 by ASME

Comparison of type I collagens and MMP-2 proteins in temporomandibular joint of young and old mice

Background: The effects of ageing on the histopathological changes of tem­poromandibular joint (TMJ) and the existence and age related alterations of immunochemical expressions of type I collagen and matrix metalloproteinase-2 (MMP-2) proteins was aimed to be displayed. Materials and methods: In this study, 14 Balb/C type white mice (50– –80 g) were included. Groups were organised as group 1 — 2-month-old young animals (n = 7) and group 2 — 18-month-old old animals (n = 7). Of the paraffin embedded tissues 4–5 μm thick sections were taken and immunohisto­chemical stainings of haematoxylin-eosin, type-1 collagen and MMP-2 were performed. Results: Collagen bundles showed sagittal and oblique localisations in the young mice, which were comprised of compact collagen bundle layers positioned alterna­tely. While collagen bundle fragmentation was observed in the disks of old mice, some disk regions showed ruptures. In the old mice a decrease in blood vessels, structural impairments and dilatation in arterioles and venules were detected. In the TMJ tissues of the young mice type I collagen and MMP-2 expressions were increased, while they were decreased in old mice. In the MMP-2 H-score evaluation young mice showed significant increase compared to the old mice. Conclusions: Occurrence of degenerations in the collagen structure of TMJ and decimation in the matrix metalloproteases were observed with age. (Folia Morphol 2018; 77, 2: 329–334

The NuSTAR, XMM-Newton, and Suzaku View of A3395 at the Intercluster Filament Interface

Galaxy clusters are the largest virialized objects in the universe. Their merger dynamics and their interactions with the cosmic filaments that connect them are important for our understanding of the formation of large-scale structure. In addition, cosmic filaments are thought to possess the missing baryons in the universe. Studying the interaction of galaxy clusters and filaments therefore has the potential to unveil the origin of the baryons and the physical processes that occur during merger stages of galaxy clusters. In this paper, we study the connection between A3395 and the intercluster filament with NuSTAR, XMM-Newton, and Suzaku data. Since the NuSTAR observation is moderately contaminated by scattered light, we present a novel technique developed for disentangling this background from the emission from the intracluster medium. We find that the interface of the cluster and the intercluster filament connecting A3395 and A3391 does not show any signs of heated plasma, as was previously thought. This interface has low temperature, high density, and low entropy, thus we suggest that the gas is cooling, being enhanced by the turbulent or tidal "weather"driven during the early stage of the merger. Furthermore, our temperature results from the NuSTAR data are in agreement with those from XMM-Newton and from joint NuSTAR and XMM-Newton analysis for a region with ∼25% scattered light contamination within 1σ. We show that the temperature constraint of the intracluster medium is valid even when the data are contaminated up to ∼25% for ∼5 keV cluster emission

Natural products and synthetic analogs as a source of antitumor drugs

Cancer is a heterogeneous disease and one of the major issues of health concern, especially for the public health system globally. Nature is a source of anticancer drugs with abundant pool of diverse chemicals and pharmacologically active compounds. In recent decade, some natural products and synthetic analogs have been investigated for the cancer treatment. This article presents the utilization of natural products as a source of antitumor drugs.This work was supported by CONICYT PIA/APOYO CCTE AFB170007

Collective Intelligence for Control of Distributed Dynamical Systems

We consider the El Farol bar problem, also known as the minority game (W. B. Arthur, ``The American Economic Review'', 84(2): 406--411 (1994), D. Challet and Y.C. Zhang, ``Physica A'', 256:514 (1998)). We view it as an instance of the general problem of how to configure the nodal elements of a distributed dynamical system so that they do not ``work at cross purposes'', in that their collective dynamics avoids frustration and thereby achieves a provided global goal. We summarize a mathematical theory for such configuration applicable when (as in the bar problem) the global goal can be expressed as minimizing a global energy function and the nodes can be expressed as minimizers of local free energy functions. We show that a system designed with that theory performs nearly optimally for the bar problem.Comment: 8 page

Tracking and imaging gamma ray experiment (TIGRE) for 1 to 100 MEV gamma ray astronomy

A large international collaboration from the high energy astrophysics community has proposed the Tracking and Imaging Gamma Ray Experiment (TIGRE) for future space observations. TIGRE will image and perform energy spectroscopy measurements on celestial sources of gamma rays in the energy range from 1 to 100 MeV. This has been a difficult energy range experimentally for gamma ray astronomy but is vital for the future considering the recent exciting measurements below 1 and above 100 MeV. TIGRE is both a double scatter Compton and gamma ray pair telescope with direct imaging of individual gamma ray events. Multi‐layers of Si strip detectors are used as Compton and pair converters CsI(Tl) scintillation detectors are used as a position sensitive calorimeter. Alternatively, thick GE strip detectors may be used for the calorimeter. The Si detectors are able to track electrons and positrons through successive Si layers and measure their directions and energy losses. Compton and pair events are completely reconstructed allowing each event to be imaged on the sky. TIGRE will provide an order‐of‐magnitude improvement in discrete source sensitivity in the 1 to 100 MeV energy range and determine spectra with excellent energy and excellent angular resolutions. It’s wide field‐of‐view of π sr permits observations of the entire sky for extended periods of time over the life of the mission

FiberGLAST: a scintillating fiber approach to the GLAST mission

FiberGLAST is a scintillating fiber gamma-ray detector designed for the GLAST mission. The system described below provides superior effective area and field of view for modest cost and risk. An overview of the FiberGLAST instrument is presented, as well as a more detailed description of the principle elements of the primary detector volume. The triggering and readout electronics are described, and Monte Carlo Simulations of the instrument performance are presented

Evidence for TeV Emission from GRB 970417a

Milagrito, a detector sensitive to very high energy gamma rays, monitored the northern sky from February 1997 through May 1998. With a large field of view and a high duty cycle, this instrument was well suited to perform a search for TeV gamma-ray bursts (GRBs). We report on a search made for TeV counterparts to GRBs observed by BATSE. BATSE detected 54 GRBs within the field of view of Milagrito during this period. An excess of events coincident in time and space with one of these bursts, GRB 970417a, was observed by Milagrito. The excess has a chance probability of $2.8 \times 10^{-5}$ of being a fluctuation of the background. The probability for observing an excess at least this large from any of the 54 bursts is $1.5 \times 10^{-3}$. No significant correlations were detected from the other bursts.Comment: 10 pages, 3 figure