Bacterial Carriage of Pathogenic Antibiotic-resistant Staphylococci Among Conditionally Healthy Infants and Preschool-age Children

Staphylococci are related to opportunistic microorganisms and are part of normal human microflora. However, there are varieties that can cause pyoinflammatory diseases in organisms with weakened immune status. In the event of an inadequate therapeutic approach, they are preserved in the body, and the person becomes a bacterial carrier and a source of dissemination of pathogenic microorganisms. The formation of antibiotic resistance also plays a significant role in the emergence of bacterial carriage. The situation is especially serious in organized children’s groups, where children are in close contact with one another. Thus, the study of the prevalence rate of antibiotic resistance among pathogenic strains of staphylococci in children’s groups is topical and worthy of attention. The purpose of this work is to identify carriers of pathogenic and antibiotic resistant staphylococci isolated from the microflora of the oral cavity of preschool children considered healthy. The results of the research can prove useful in practical healthcare and, particularly, in pediatric practice. Keywords: staphylococci, pathogenic cocci, bacterial carriage, antibiotic resistance, infant morbidity rat

Cerebrovascular accidents in patients with type 2 diabetes mellitus

Cerebrovascular accident (CA) is a nowadays widely spread, highly incapacitating and often lethal event that poses a prominent clini- cal problem. Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) ? an ?epidemic? of the century, ? are known to be its primary risk factors. Hyperglycemia promotes CA risks by induction of protein glycosylation, elevation of blood plasma atherogenic potential, activation of coagulation system with higher risk for thrombosis and disturbance of microcirculation on tissue and organ lev- els. Influence of hyperglycemia on severity and extent of neurologic damage is still under evaluation. Development of macroangiopathy is thought to be associated with media calcification, distal polyneuropathy and renal disorders, all of which are cardiovascular risk factors. Application of so-called metabolic drugs resulted in certain disillusionment, as these agents failed to prove their efficacy during clinical trials. Incidence of pulmonary edema in patients with ischemic CA and T2DM is important as it dictates the necessity for use of loop diuretics. Incidence and severity of heart failure and its correlation with degree of glycemic disorders, incidence of pulmonary em- bolism, as well as tactics of management and prognosis in patients with ischemic CA and T2DM, remains a relevant research problem

Multimodal metal cation sensing with bis(macrocyclic) dye

The synthesis, electrochemical, optical, and cation sensing properties of a bis(macrocyclic) dye 1, in which the benzo-15-crown-5 and phenylazathia-15-crown-5 subunits are linked through a styryl pyridinium moiety, are reported. In this new ditopic receptor, the benzo-15-crown-5 macrocycle acts as a highly selective binding site for alkaline earth metal cations (MgII and BaII), whereas the phenylazathia-15-crown-5 displays a strong binding affinity towards soft heavy-metal cations (HgII and AgI). The pronounced changes of the absorption and fluorescence spectra of this bichromophoric dye observed upon different metal cation addition make the dye suitable for dual-wavelength analysis and offer an enticing potential for multitasking sensors

Sources of economically valuable traits for covered oat breeding

Using of genetic diversity is one of the factors of successful oat breeding. Screening of sources with high yield, resistance to abiotic (high soil acidity and drougth) and biotic (pathogens) stressors, early maturity, high grain quality is actual for Volga-Vyatka region. Studies were conducted in contrast climatic conditions on favorable and natural acid (provocative) soil backgrounds in Kirov region. The most promising accessions are 15068 Konkur (Russia) and 14983 Hybrid (Mexico) having resistance to soil acidity and drought and high grain quality. Accessions 15069 Rysak (Russia), 14967 Florida 657 (USA), and 15082 Ivory (Germany) are recommended to include in crossing with adaptive varieties of local breeding. Sources are selected having high resistanse to soil acidity and high grain quality: 15065 Irtysh (Russia), Yakov (Russia), 15127 SW Betania (Sweden), 15052 Rigja (Norway), 14966 Winter Dum (South Africa) etc. For breeding to early maturity accessions 22h10 Eaton (Russia), 14964 Zwarte president (Netherlands), 15257 RA 7836-416, 15258 RA 7836-2701, 15264 RA 7967-11690, 14620 Newman (USA), 15111 L-15 (Colombia), 15027 C.I. 9101 (Turkey), 14991 ОА 309 (Canada) etc are recommended as paternal forms. Sources of high grain quality and resistance to pathogens are 15184 AC-7 (Russia), 14970 Illinois 62-1532 (USA), 14535 Urano Inia (Chile) etc

Multimodal metal cation sensing with bis(macrocyclic) dye

The synthesis, electrochemical, optical, and cation sensing properties of a bis(macrocyclic) dye 1, in which the benzo-15-crown-5 and phenylazathia-15-crown-5 subunits are linked through a styryl pyridinium moiety, are reported. In this new ditopic receptor, the benzo-15-crown-5 macrocycle acts as a highly selective binding site for alkaline earth metal cations (MgII and BaII), whereas the phenylazathia-15-crown-5 displays a strong binding affinity towards soft heavy-metal cations (HgII and AgI). The pronounced changes of the absorption and fluorescence spectra of this bichromophoric dye observed upon different metal cation addition make the dye suitable for dual-wavelength analysis and offer an enticing potential for multitasking sensors

Metal ions drive thermodynamics and photochemistry of the Bis(styryl) macrocyclic tweezer

UV/Vis and NMR spectroscopy were used for the structural elucidation and thermodynamic and photochemical studies of the metal-coordinated crown-containing macrocyclic tweezer (E,E)-1. The bis(styryl) tweezer (E,E)-1 formed two types of complexes with magnesium(II): a 1:1 intramolecular asymmetric sandwich complex [(E,E)-1]·Mg2+ and a 1:2 complex [(E,E)-1]·(Mg2+)2. In the former case, there is direct cation intramolecular exchange (0.299 s-1, ΔG≠=69.4 kJ mol-1) between two parts of the bis(styryl) tweezer (E,E)-1. Addition of barium(II) to the bis(styryl) tweezer (E,E)-1 led to an intramolecular centrosymmetric sandwich 1:1 complex [(E,E)-1]·Ba2+. Irradiation of [(E,E)-1]·Ba2+ afforded reversible intramolecular [2π+2π] photocyclization with excellent stereoselectivity and quantitative yield. In contrast, irradiation of [(E,E)-1](Mg2+)2 resulted in reversible stepwise E,Z-isomerization

Spectroscopic study of mono- and bis(styryl) dyes of the pyridinium series containing azathiacrown ether residue

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