284 research outputs found
Acquaintances or Familiar Strangers?:How Similarity and Spatial Proximity Shape Neighbour Relations within Residential Buildings
While scholars have long established that city dwellers choose with whom to develop relationships on the basis of social proximity, spatial proximity remains the basis for neighbour relations involving greetings, social conversation, and the exchange of services. Few studies have systematically compared the respective roles of spatial and social proximity in neighbour relations. In this paper, we investigate these two factors through statistical analysis of four social network datasets representing relationships within four rented apartment buildings in Geneva, Switzerland. Using a measure of distance that takes into account how the layout and materiality of buildings shape relationships through accessibility, visibility and audibility, we compare the effects of spatial proximity with the effects of individual determinants and similarity. Our study also breaks new ground by comparing weak ties–between people who interact regularly–and “invisible ties”, or ties to familiar strangers. Our study confirms that spatial proximity increases the likelihood of weak ties and questions the underlying mechanisms. It also shows that in addition to sociability, familiarity and anonymity are constitutive dimensions of neighbouring, even at the scale of buildings
New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity.
Interleukin-15 (IL-15) is a potent cytokine that increases CD8+ T and NK cell numbers and function in experimental models. However, obstacles remain in using IL-15 therapeutically, specifically its low potency and short in vivo half-life. To help overcome this, a new IL-15 superagonist complex comprised of an IL-15N72D mutation and IL-15RαSu/Fc fusion (IL-15SA, also known as ALT-803) was developed. IL-15SA exhibits a significantly longer serum half-life and increased in vivo activity against various tumors. Herein, we evaluated the effects of IL-15SA in recipients of allogeneic hematopoietic stem cell transplantation. Weekly administration of IL-15SA to transplant recipients significantly increased the number of CD8+ T cells (specifically CD44+ memory/activated phenotype) and NK cells. Intracellular IFN-γ and TNF-α secretion by CD8+ T cells increased in the IL-15SA-treated group. IL-15SA also upregulated NKG2D expression on CD8+ T cells. Moreover, IL-15SA enhanced proliferation and cytokine secretion of adoptively transferred CFSE-labeled T cells in syngeneic and allogeneic models by specifically stimulating the slowly proliferative and nonproliferative cells into actively proliferating cells.We then evaluated IL-15SA\u27s effects on anti-tumor activity against murine mastocytoma (P815) and murine B cell lymphoma (A20). IL-15SA enhanced graft-versus-tumor (GVT) activity in these tumors following T cell infusion. Interestingly, IL-15 SA administration provided GVT activity against A20 lymphoma cells in the murine donor leukocyte infusion (DLI) model without increasing graft versus host disease. In conclusion, IL-15SA could be a highly potent T- cell lymphoid growth factor and novel immunotherapeutic agent to complement stem cell transplantation and adoptive immunotherapy
Spectral up- and downshifting of Akhmediev breathers under wind forcing
We experimentally and numerically investigate the effect of wind forcing on
the spectral dynamics of Akhmediev breathers, a wave-type known to model the
modulation instability. We develop the wind model to the same order in
steepness as the higher order modifcation of the nonlinear Schroedinger
equation, also referred to as the Dysthe equation. This results in an
asymmetric wind term in the higher order, in addition to the leading order wind
forcing term. The derived model is in good agreement with laboratory
experiments within the range of the facility's length. We show that the leading
order forcing term amplifies all frequencies equally and therefore induces only
a broadening of the spectrum while the asymmetric higher order term in the
model enhances higher frequencies more than lower ones. Thus, the latter term
induces a permanent upshift of the spectral mean. On the other hand, in
contrast to the direct effect of wind forcing, wind can indirectly lead to
frequency downshifts, due to dissipative effects such as wave breaking, or
through amplification of the intrinsic spectral asymmetry of the Dysthe
equation. Furthermore, the definitions of the up- and downshift in terms of
peak- and mean frequencies, that are critical to relate our work to previous
results, are highlighted and discussed.Comment: 30 pages, 11 figure
The Fermi-Pasta-Ulam recurrence and related phenomena for 1D shallow-water waves in a finite basin
In this work, different regimes of the Fermi-Pasta-Ulam (FPU) recurrence are
simulated numerically for fully nonlinear "one-dimensional" potential water
waves in a finite-depth flume between two vertical walls. In such systems, the
FPU recurrence is closely related to the dynamics of coherent structures
approximately corresponding to solitons of the integrable Boussinesq system. A
simplest periodic solution of the Boussinesq model, describing a single soliton
between the walls, is presented in an analytical form in terms of the elliptic
Jacobi functions. In the numerical experiments, it is observed that depending
on a number of solitons in the flume and their parameters, the FPU recurrence
can occur in a simple or complicated manner, or be practically absent. For
comparison, the nonlinear dynamics of potential water waves over nonuniform
beds is simulated, with initial states taken in the form of several pairs of
colliding solitons. With a mild-slope bed profile, a typical phenomenon in the
course of evolution is appearance of relatively high (rogue) waves, while for
random, relatively short-correlated bed profiles it is either appearance of
tall waves, or formation of sharp crests at moderate-height waves.Comment: revtex4, 10 pages, 33 figure
Supergauge interactions and electroweak baryogenesis
We present a complete treatment of the diffusion processes for supersymmetric
electroweak baryogenesis that characterizes transport dynamics ahead of the
phase transition bubble wall within the symmetric phase. In particular, we
generalize existing approaches to distinguish between chemical potentials of
particles and their superpartners. This allows us to test the assumption of
superequilibrium (equal chemical potentials for particles and sparticles) that
has usually been made in earlier studies. We show that in the Minimal
Supersymmetric Standard Model, superequilibrium is generically maintained --
even in the absence of fast supergauge interactions -- due to the presence of
Yukawa interactions. We provide both analytic arguments as well as illustrative
numerical examples. We also extend the latter to regions where analytical
approximations are not available since down-type Yukawa couplings or supergauge
interactions only incompletely equilibrate. We further comment on cases of
broken superequilibrium wherein a heavy superpartner decouples from the
electroweak plasma, causing a kinematic bottleneck in the chain of
equilibrating reactions. Such situations may be relevant for baryogenesis
within extensions of the MSSM. We also provide a compendium of inputs required
to characterize the symmetric phase transport dynamics.Comment: 49 pages, 9 figure
Double Haploidentical Hematopoietic Stem Cell Transplantation Results in Successful Engraftment of Bone Marrow from Both Donors without Graft-versus-Host or Graft-versus-Graft Effects
We established double-haploidentical (DH) hematopoietic stem cell transplantation (HSCT) murine models to explore competitive engraftment, graft-versus-graft effect and graft-versus-host disease (GVHD). T cell–depleted (TCD) bone marrow (BM) cells from B6SJF1 (donor 1 [D1]) and B6D2F1 (donor 2 [D2]) mice achieved >90% donor engraftment when transplanted into B6CBAF1 mice. B6CBAF1 recipients survived without evidence of GVHD when undergoing HSCT with TCD-BM from 2 haploidentical donors, D1 and D2. DH-HSCT recipients had significantly higher leukocyte and neutrophil counts than single-haploidentical HSCT recipients from either D1 or D2. DH recipients consistently showed successful mixed chimerism in both BM and spleen. Two other DH-HSCT models, B6D2F1 + C3D2F1→B6C3F1 and B6CBAF1 + B6SJLF1→B6D2F1, showed similar engraftment patterns. Low-dose T cell infusion from both D1 and D2 increased the degree of early engraftment of the respective donors in BM and spleen; however, this early engraftment pattern did not determine long-term engraftment dominance. In the long term, minimally engrafted D1 BM recovered and comprised >50% of all donor- derived B, T, and natural killer cells. We conclude that early BM engraftment is determined by donor T cell immunodominance, but long-term engraftment is related to the engraftment potential of stem cells after DH-HSCT
Freak Waves in Random Oceanic Sea States
Freak waves are very large, rare events in a random ocean wave train. Here we
study the numerical generation of freak waves in a random sea state
characterized by the JONSWAP power spectrum. We assume, to cubic order in
nonlinearity, that the wave dynamics are governed by the nonlinear Schroedinger
(NLS) equation. We identify two parameters in the power spectrum that control
the nonlinear dynamics: the Phillips parameter and the enhancement
coefficient . We discuss how freak waves in a random sea state are more
likely to occur for large values of and . Our results are
supported by extensive numerical simulations of the NLS equation with random
initial conditions. Comparison with linear simulations are also reported.Comment: 7 pages, 6 figures, to be published in Phys. Rev. Let
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