Acquaintances or Familiar Strangers?:How Similarity and Spatial Proximity Shape Neighbour Relations within Residential Buildings

While scholars have long established that city dwellers choose with whom to develop relationships on the basis of social proximity, spatial proximity remains the basis for neighbour relations involving greetings, social conversation, and the exchange of services. Few studies have systematically compared the respective roles of spatial and social proximity in neighbour relations. In this paper, we investigate these two factors through statistical analysis of four social network datasets representing relationships within four rented apartment buildings in Geneva, Switzerland. Using a measure of distance that takes into account how the layout and materiality of buildings shape relationships through accessibility, visibility and audibility, we compare the effects of spatial proximity with the effects of individual determinants and similarity. Our study also breaks new ground by comparing weak ties–between people who interact regularly–and “invisible ties”, or ties to familiar strangers. Our study confirms that spatial proximity increases the likelihood of weak ties and questions the underlying mechanisms. It also shows that in addition to sociability, familiarity and anonymity are constitutive dimensions of neighbouring, even at the scale of buildings

New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity.

Interleukin-15 (IL-15) is a potent cytokine that increases CD8+ T and NK cell numbers and function in experimental models. However, obstacles remain in using IL-15 therapeutically, specifically its low potency and short in vivo half-life. To help overcome this, a new IL-15 superagonist complex comprised of an IL-15N72D mutation and IL-15RαSu/Fc fusion (IL-15SA, also known as ALT-803) was developed. IL-15SA exhibits a significantly longer serum half-life and increased in vivo activity against various tumors. Herein, we evaluated the effects of IL-15SA in recipients of allogeneic hematopoietic stem cell transplantation. Weekly administration of IL-15SA to transplant recipients significantly increased the number of CD8+ T cells (specifically CD44+ memory/activated phenotype) and NK cells. Intracellular IFN-γ and TNF-α secretion by CD8+ T cells increased in the IL-15SA-treated group. IL-15SA also upregulated NKG2D expression on CD8+ T cells. Moreover, IL-15SA enhanced proliferation and cytokine secretion of adoptively transferred CFSE-labeled T cells in syngeneic and allogeneic models by specifically stimulating the slowly proliferative and nonproliferative cells into actively proliferating cells.We then evaluated IL-15SA\u27s effects on anti-tumor activity against murine mastocytoma (P815) and murine B cell lymphoma (A20). IL-15SA enhanced graft-versus-tumor (GVT) activity in these tumors following T cell infusion. Interestingly, IL-15 SA administration provided GVT activity against A20 lymphoma cells in the murine donor leukocyte infusion (DLI) model without increasing graft versus host disease. In conclusion, IL-15SA could be a highly potent T- cell lymphoid growth factor and novel immunotherapeutic agent to complement stem cell transplantation and adoptive immunotherapy

Spectral up- and downshifting of Akhmediev breathers under wind forcing

We experimentally and numerically investigate the effect of wind forcing on the spectral dynamics of Akhmediev breathers, a wave-type known to model the modulation instability. We develop the wind model to the same order in steepness as the higher order modifcation of the nonlinear Schroedinger equation, also referred to as the Dysthe equation. This results in an asymmetric wind term in the higher order, in addition to the leading order wind forcing term. The derived model is in good agreement with laboratory experiments within the range of the facility's length. We show that the leading order forcing term amplifies all frequencies equally and therefore induces only a broadening of the spectrum while the asymmetric higher order term in the model enhances higher frequencies more than lower ones. Thus, the latter term induces a permanent upshift of the spectral mean. On the other hand, in contrast to the direct effect of wind forcing, wind can indirectly lead to frequency downshifts, due to dissipative effects such as wave breaking, or through amplification of the intrinsic spectral asymmetry of the Dysthe equation. Furthermore, the definitions of the up- and downshift in terms of peak- and mean frequencies, that are critical to relate our work to previous results, are highlighted and discussed.Comment: 30 pages, 11 figure

The Fermi-Pasta-Ulam recurrence and related phenomena for 1D shallow-water waves in a finite basin

In this work, different regimes of the Fermi-Pasta-Ulam (FPU) recurrence are simulated numerically for fully nonlinear "one-dimensional" potential water waves in a finite-depth flume between two vertical walls. In such systems, the FPU recurrence is closely related to the dynamics of coherent structures approximately corresponding to solitons of the integrable Boussinesq system. A simplest periodic solution of the Boussinesq model, describing a single soliton between the walls, is presented in an analytical form in terms of the elliptic Jacobi functions. In the numerical experiments, it is observed that depending on a number of solitons in the flume and their parameters, the FPU recurrence can occur in a simple or complicated manner, or be practically absent. For comparison, the nonlinear dynamics of potential water waves over nonuniform beds is simulated, with initial states taken in the form of several pairs of colliding solitons. With a mild-slope bed profile, a typical phenomenon in the course of evolution is appearance of relatively high (rogue) waves, while for random, relatively short-correlated bed profiles it is either appearance of tall waves, or formation of sharp crests at moderate-height waves.Comment: revtex4, 10 pages, 33 figure

Supergauge interactions and electroweak baryogenesis

We present a complete treatment of the diffusion processes for supersymmetric electroweak baryogenesis that characterizes transport dynamics ahead of the phase transition bubble wall within the symmetric phase. In particular, we generalize existing approaches to distinguish between chemical potentials of particles and their superpartners. This allows us to test the assumption of superequilibrium (equal chemical potentials for particles and sparticles) that has usually been made in earlier studies. We show that in the Minimal Supersymmetric Standard Model, superequilibrium is generically maintained -- even in the absence of fast supergauge interactions -- due to the presence of Yukawa interactions. We provide both analytic arguments as well as illustrative numerical examples. We also extend the latter to regions where analytical approximations are not available since down-type Yukawa couplings or supergauge interactions only incompletely equilibrate. We further comment on cases of broken superequilibrium wherein a heavy superpartner decouples from the electroweak plasma, causing a kinematic bottleneck in the chain of equilibrating reactions. Such situations may be relevant for baryogenesis within extensions of the MSSM. We also provide a compendium of inputs required to characterize the symmetric phase transport dynamics.Comment: 49 pages, 9 figure

Double Haploidentical Hematopoietic Stem Cell Transplantation Results in Successful Engraftment of Bone Marrow from Both Donors without Graft-versus-Host or Graft-versus-Graft Effects

We established double-haploidentical (DH) hematopoietic stem cell transplantation (HSCT) murine models to explore competitive engraftment, graft-versus-graft effect and graft-versus-host disease (GVHD). T cell–depleted (TCD) bone marrow (BM) cells from B6SJF1 (donor 1 [D1]) and B6D2F1 (donor 2 [D2]) mice achieved >90% donor engraftment when transplanted into B6CBAF1 mice. B6CBAF1 recipients survived without evidence of GVHD when undergoing HSCT with TCD-BM from 2 haploidentical donors, D1 and D2. DH-HSCT recipients had significantly higher leukocyte and neutrophil counts than single-haploidentical HSCT recipients from either D1 or D2. DH recipients consistently showed successful mixed chimerism in both BM and spleen. Two other DH-HSCT models, B6D2F1 + C3D2F1→B6C3F1 and B6CBAF1 + B6SJLF1→B6D2F1, showed similar engraftment patterns. Low-dose T cell infusion from both D1 and D2 increased the degree of early engraftment of the respective donors in BM and spleen; however, this early engraftment pattern did not determine long-term engraftment dominance. In the long term, minimally engrafted D1 BM recovered and comprised >50% of all donor- derived B, T, and natural killer cells. We conclude that early BM engraftment is determined by donor T cell immunodominance, but long-term engraftment is related to the engraftment potential of stem cells after DH-HSCT

Freak Waves in Random Oceanic Sea States

Freak waves are very large, rare events in a random ocean wave train. Here we study the numerical generation of freak waves in a random sea state characterized by the JONSWAP power spectrum. We assume, to cubic order in nonlinearity, that the wave dynamics are governed by the nonlinear Schroedinger (NLS) equation. We identify two parameters in the power spectrum that control the nonlinear dynamics: the Phillips parameter $\alpha$ and the enhancement coefficient $\gamma$. We discuss how freak waves in a random sea state are more likely to occur for large values of $\alpha$ and $\gamma$. Our results are supported by extensive numerical simulations of the NLS equation with random initial conditions. Comparison with linear simulations are also reported.Comment: 7 pages, 6 figures, to be published in Phys. Rev. Let