Mutation analysis of PRSS1, SPINK1 and CFTR gene in patients with alcoholic and idiopathic chronic pancreatitis: A single center study

Background/Aims: A relation between some genetic mutations and chronic pancreatitis (CP) has been reported. However, the relation of genetic mutation to alcoholic CP (ACP) and idiopathic CP (ICP) still remains controversial. In this study, we investigated the prevalence of protease serine 1 (PRSS1), serine protease inhibitor, Kazal type 1 (SPINK1) SPINK1 and cystic fibrosis transmembrane conductance regulator (CFTR) mutations in ACP and ICP patients in Turkey

Comparison of Levels of Zinc, Iron and Cadmium in Classic Meningioma and Glioblastoma Multiforme

Objectives: The aim of this study was to compare trace elements (zinc (Zn), iron (Fe) and cadmium (Cd)) in tissue samples of classic meningiomas and glioblastoma multiformes

The Morpho-functional Evaluation of Retina in Amblyopia

Purpose: To investigate the morphological or functional differences of retina in amblyopia

Importación de Lactdew de Yakutl Japón a México

El presente trabajo pretende resaltar los aspectos estratégicos que se tienen para la importación de Lactdew de Yakutl Japón a México. Se estima que debido al crecimiento de la empresa en México se encuentra en expansión y por tal motivo nos mueve a realizar el análisis del proyecto para poder introducir la linea Lactdew

A SUCCESSFUL KIDNEY TRANSPLANTATION WITH PROPHYLACTIC ECULIZUMAB TREATMENT IN A PATIENT WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME

WOS: 000367726702468

A Case of Dengue Fever Complicated with Trombophlebitis in a Child

Dengue fever is a disease characterized by flu like symptoms which is endemic in tropic and subtropic regions. Dengue virus is from Filavivirus family. Dengue fever is rarely seen in our country. Hemorrhagic and thrombotic complications can be observed during the course of the disease. Herein we present a child case of Dengue fever diagnosed in our country who was complicated with thrombophlebitis. A previously healthy 16-year old boy was presented with headache, malaise and fever lasting for six days. He had returned from Philippines a week ago where he had stayed for a month. On physical examination, he was dehydrated with fever of 39.3 degrees C. His heart rate was 109/min, respiratory rate was 28/min, blood pressure was 132/78 mmHg, oxygen saturation was %96 (room air) and capillary refill time was 5 seconds. His oral mucosa was dry and turgor was decreased. He had generalized erythematous rash, muscle pain and 2 cm splenomegaly. Laboratory examination revealed polycythemia and thrombocytopenia. He was hospitalized and intravenous hydration was initiated because of severe dehydratation and hemoconcentration. His history revealed that his roommate in Philippines was diagnosed as Dengue fever, recently. Pain and limitation of movement on left antecubital region developped on follow-up. Peripheral pulses could be palpated on both distal extremities and there was no difference of heat. Superficial doppler ultrasonography revealed echogenic thrombus extending from cephalic vein to wrist, and basilic vein to axillary region without recanalization. He was started on enoxaparin treatment. Serum Dengue fever IgM and IgG were reported as positive and he was discharged with recovery one week after hospitalization. Dengue fever should be considered as differential diagnosis of patients with flulike symptoms who had travel history to endemic countries. Hemorrhagic complications and hemorrhagic shock syndrome which are frequently seen in patients with Dengue fever can cause mortality. In addition, superficial and deep vein thrombosis can be observed in severely dehydrated patients with Dengue fever. These patients should be carefully observed for possible thromboembolic complications

Screening of antioxidant and cytotoxic activities of several microalgal extracts with pharmaceutical potential

WOS: 000519938500011The bioactive molecules from microalgae have important properties such as antioxidant, anticancer, antiviral, antibacterial, antihypertensive, skin regenerative, neuroprotective, sunscreen, and, immunostimulatory effects. Bioactive molecules derived from microalgae is getting intense attention from pharmaceuticals, cosmetics and nutraceuticals industries because of these properties and numerous researches have been done to investigate the role of these bioactive molecules that can enlighten microalgal biotechnology to result in new nature derived pharmaceutical formulations. in this study we investigate antioxidant activities of crude extracts of G. Galdieria sulphuraria, Ettlia carotinosa, Neochloris texensis, Chlorella minutissima, Stichococcus bacillaris, Schizochytrium limacinum, Crypthecodinium cohnii, and Chlorella vulgaris with determining radical scavenging activity (RSA) by DPPH (2,2-diphenyl-1-picrylhydrazyl hydrate radical) method and total phenolic content by Folin-Ciocalteu method. Selected extracts according to their antioxidant activities cytotoxicity was evaluated after exposure to human hepatocellular liver carcinoma cells (HepG2) for 48 h. Antioxidant activities of these species ranged from 89 to 95% RSA (radical scavenging activity) while their phenolic contents were also very high, varied from 41 to 312 mg GAE (gallic acid equivalents)/mg extract. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay also showed microalgae has a potential to be used as a novel therapeutic compound