87 research outputs found
Resposta em parâmetros sanguíneos e urinários de vacas leiteiras ao aumento no balanço cátion-aniônico da dieta
Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting
Detectable clonal mosaicism and its relationship to aging and cancer
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases
Endoplasmic Reticulum Stress Modulation as a Target for Ameliorating Effects of Blast Induced Traumatic Brain Injury
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Progress in direct heat applications projects
The development of hydrothermal energy for direct heat applications is being aided by twenty-two demonstration projects that are funded on a cost-sharing basis by the US Department of Energy, Division of Geothermal Energy. These projects are designed to demonstrate the technical and economic feasibility of the direct use of geothermal heat in the United States. Twelve of these projects are administered by the DOE-Idaho Operations Office with technical support from EG and G Idaho, Inc. Engineering and economic data for these projects are summarized in this paper. The data and experience being generated by these projects will be an important basis for future geothermal direct use projects
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Long-term Failure Patterns and Survival in a Randomized Dose-escalation Trial for Prostate Cancer. Who Dies of Disease?
Neuropsychological assessment of children and adolescents with systemic lupus erythematosus
Sex-autosome translocations: meiotic behaviour suggests an inactivation block with permanence of autosomal gene activity in Phyllostomid bats
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