Conversion from linear to circular polarization in FPGA

Context: Radio astronomical receivers are now expanding their frequency range to cover large (octave) fractional bandwidths for sensitivity and spectral flexibility, which makes the design of good analogue circular polarizers challenging. Better polarization purity requires a flatter phase response over increasingly wide bandwidth, which is most easily achieved with digital techniques. They offer the ability to form circular polarization with perfect polarization purity over arbitrarily wide fractional bandwidths, due to the ease of introducing a perfect quadrature phase shift. Further, the rapid improvements in field programmable gate arrays provide the high processing power, low cost, portability and reconfigurability needed to make practical the implementation of the formation of circular polarization digitally. Aims: Here we explore the performance of a circular polarizer implemented with digital techniques. Methods: We designed a digital circular polarizer in which the intermediate frequency signals from a receiver with native linear polarizations were sampled and converted to circular polarization. The frequency-dependent instrumental phase difference and gain scaling factors were determined using an injected noise signal and applied to the two linear polarizations to equalize the transfer characteristics of the two polarization channels. This equalization was performed in 512 frequency channels over a 512 MHz bandwidth. Circular polarization was formed by quadrature phase shifting and summing the equalized linear polarization signals. Results: We obtained polarization purity of -25 dB corresponding to a D-term of 0.06 over the whole bandwidth. Conclusions: This technique enables construction of broad-band radio astronomy receivers with native linear polarization to form circular polarization for VLBI.Comment: 11 pages 8 figure

AntArr – Etna Low Frequency Antenna Array

AbstractA project called AntArr as a new application of the DBBC3 (Digital Base Band Converter, 3rd generation) is under development. A group of antennas operating at low frequency, in the range from 10 MHz up to 1500 MHz, are phased up for VLBI, pulsar and more recently for FRB observations. Part of the scientific programme is also dedicated to SETI activities in piggy-back mode. Dedicated elements can even be added to reach still lower frequencies to observe the range down to kHz frequencies. The DBBC3 manages the array operations in a selected portion of the band and the main characteristic is to synthesize a beam with an innovative approach. The final product of the array is a single station standard VLBI data stream for correlation with other antennas, or a synthesized beam for single dish observations. A number of antennas and array prototypes are under test at a location on the Etna volcano slope, with the aim to form a complete radio telescope of up to 1024 elements in 2020 and beyond. This project completes the lower part of the frequency spectrum covered in VLBI by the BRAND EVN project. The project AntArr is hosted and financed by HAT-Lab Ltd., which is the manufacturer of the DBBC family backends

HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach

Objectives. HER2 expression in gastric cancer (GC) has received attention as a potential target for therapy with Trastuzumab. We reviewed the current knowledge on HER2 status in premalignant gastric lesions and in early (EGC) and advanced (AGC) GC to discuss the possible pathogenetic and prognostic roles of HER2 overexpression in GC. Results. HER2 overexpression was documented in gastric low-grade (LG) and high-grade intraepithelial neoplasia (HG-IEN), with higher frequency in gastric type dysplasia. HER2 overexpression was significantly associated with disease recurrence and poor prognosis in EGC representing an independent risk factor for lymph node metastases. HER2 overexpression was more frequent in AGC characterized by high grade, advanced stage, and high Ki-67 labeling index. The discordance in HER2 status was evidenced between primitive GC and synchronous or metachronous metastases. Conclusions. HER2 overexpression in premalignant gastric lesions suggests its potential involvement in the early steps of gastric carcinogenesis. The assessment of HER2 status in EGC may be helpful for the identification of patients who are at low risk for developing nodal metastases. Finally, the possible discordance in HER2 status between primary GC and its synchronous metastases support routine assessment of HER2 both in the primary GC and in its metastatic lesions

Human Epidermal Growth Factor Receptor 2 Status in Gastric Carcinomas with Distinctive Prevalent Cribriform Component

A cribriform architectural pattern has been reported in 9% of one unselected consecutively collected series of gastric carcinomas (GC) with unfavourable prognostic outcome. Taking into consideration the biological relevance of the human epidermal growth factor receptor 2 (HER2) status, we have analyzed a cohort of GC with a cribriform component more than 40% (CGC) to evaluate the HER2 amplification rate as a potential target for therapy with trastuzumab

Immunohistochemical localization and functional characterization of somatostatin receptor subtypes in a corticotropin releasing hormone-secreting adrenal phaeochromocytoma: review of the literature and report of a case

Somastostatin receptors are frequently expressed in phaeochromocytoma but data on somatostatin receptor subtyping are scanty and the functional response to the somatostatin analogue octretide is still debated.We report an unusual case of pheochromocytoma, causing ectopic Cushing’s syndrome due to CRH production by the tumour cells, in a 50-yr-old woman. Abdominal computed tomography revealed an inhomogeneous, 9-cm mass in the right adrenal gland, and [111In-DTPA0] octreotide scintigraphy showed an abnormal uptake of the radiotracer in the right perirenal region, corresponding to the adrenal mass. The patient underwent laparoscopic surgery and formalin-fixed and paraffin-embedded samples were studied. The tumour was extensively characterized by immunohistochemistry and somatostatin receptor (SSTRs) subtypes expression was analyzed. Histological and immunohistochemical examination of the surgical specimens displayed a typical pheochromocytoma, which was found to be immunoreative to S-100, chromogranin A and neurofilaments. Immunostaining for SSTR subtypes showed a positive reaction for SSTR1, SSTR2A, SSTR2B, antisera on tumour cells. The intense and diffuse immunostaining for corticotropin releasing hormone (CRH) antiserum indicated that Cushing’s disease was dependent on CRH overproduction by the pheochromocytoma, in which no immunostaining for adrenocorticotropic hormone was found. Our report confirms the heterogeneity of the pattern of SSTR expression in pheochromocytomas, and provide further evidence for functional SSTR subtype SSTR2a in a subgroup of pheochromocytomas, suggesting that these tumours may represent potential target for octreotide treatment

Immunolocalization of lactoferrin in surgically resected pigmented skin lesions

Lactoferrin (Lf) expression was determined immunohistochemically in 57 formalin-fixed paraffin-embedded bioptic samples obtained from an equal number of patients treated by surgery to remove pigmented skin lesions (nevi = 23; melanoma = 12; vulgaris and seborrhoeic warts = 12; basal cell carcinoma = 10); in addition, 10 specimens of normal skin were studied as control. On 3 ?m thick sections, depigmentation and antigen retrieval procedures were performed. The Lf immunoreactivity was revealed by a rabbit anti-human Lf. Quantification of Lf immunoreactivity was performed using an intensity-distribution (ID) score. Melanocytic cells, regardless of their benign or malignant nature, were consistently stained, with no significant differences in the Lf IDscore between melanomas or nevi. A different intensity of Lf immunoreactivity was encountered in superficial portions of warts, exclusively inside squamous epithelial cells arranged in sheets or whorls of keratin. On the contrary, basal cell carcinomas were always unstained, while a slight Lf positivity was found in focal keratinized areas present in two tumours showing baso-squamous differentiation. The Lf immunoreactivity was localized in the cytoplasm and only occasionally in the nucleus. The biological meaning of Lf in these cases of human skin specimens remains unexplained, although it cannot be ruled out that Lf might be involved in the defense system against tumours, or alternatively, may be used by cells requiring iron availability for their turnover. Moreover, the immunohistochemical expression of Lf in melanocytic lesions might be also related to a Lf-melanin interaction. Finally, the involvement of Lf in skin squamous non-neoplastic elements could be related to its role as one of the molecules modulating an unspecific inflammatory or anti-oxidant response