Characterization of the Shear-Induced Potential (SIP) in Clay and the Application to Landslide Sites

Electrical polarizations were observed in common fine soil aggregates in shear deformation tests and simulations conducted in a laboratory. This electric potential is called Shear-induced Potential (SIP). The SIP can be interpreted as the physicochemical interaction between the surface of clay particles and interstitial water by the kinetics of the electric double layer. The SIP could not be detected in a remolded craft clay sample, which was possibly treated with electrically non-dipole oil. In the laboratory, a plane strain test under the un-drained condition was carried out to reveal the characteristics of the polarization accompanying the shear deformation. Gouges from the active faults were remolded with saline water and consolidated axially under the condition of K0 as the test specimen. The polarities of the electric charges induced at the surfaces of the specimens were positive, neutral and negative for the maximum (tensional), intermediate and minimum principal strain axial planes, respectively. In addition, in-situ observations of the spontaneous potential (SP) were performed at gravitationally unstable sites to verify the results obtained in the laboratory. The characteristic distributions of the charge and time variation of SP were consistent with the pattern observed by the scaled model experiments in the laboratory

実験的な歯の移動に対するレーザー照射の組織学的および分子生物学的効果

広島大学(Hiroshima University)博士(歯学)Philosophy in Dental Sciencedoctora

Efficacy of Abdominal Ultrasonography for Differentiation of Gastrointestinal Diseases in Calves

Gastrointestinal diseases represent one of the common causes of bovine acute abdomen, such as abdominal distention, abdominal pain, and cessation of defecation. In addition to the observable signs when performing routine auscultation, rectal palpation, and biochemical examinations of ruminal fluid and blood, these clinical observations can provide evidence suggestive of these diseases, but they generally result in an inconclusive diagnosis. Therefore, exploratory laparotomy is often used because it facilitates both diagnosis and therapeutic decisions. For bovines, abdominal ultrasonography is frequently utilized as a convenient imaging modality to assist accurate diagnosis and contribute to subsequent appropriate therapeutic choices for bovine gastrointestinal diseases. According to recent trends in human medicine and small animal practice, technical improvements have led to developments in the diagnostic value of abdominal ultrasonography, including scanning methods and the establishment of valuable diagnostic signs specific to a particular disease, e.g., a target sign for intussusception.This study investigated the clinical efficacy of abdominal ultrasonography for abomasal dilation in three calves, intestinal volvulus in five calves, intussusception in one calf, and internal hernia in one calf. In the abdominal ultrasonograms of the abomasal dilation cases, this disease was commonly characterized by severely extended lumens, including heterogeneously hyperechoic ingesta without intraluminal accumulations of gas. In the animals with intestinal volvulus and intussusception, a to-and-fro flow was observed to be a common ultrasonographic characteristic that led to suspicion of an intestinal obstruction. The use of abdominal ultrasonography for five cases with intestinal volvulus gave no reason to suspect this disease, despite its efficacy in one case, based on an acutely angled narrowing. Although three of five animals with intestinal volvulus had intestinal ruptures, no ultrasonographic evidence could be obtained. When abdominal ultrasonography was used for one case with intussusception, this pathological condition could be strongly suspected, as a “target” sign was observed. This finding supported surgical intervention for this case, followed by treatment with manual reduction, resulting in a favorable outcome. In terms of the differential and definitive diagnosis for various intestinal diseases, abdominal ultrasonography may be poor at providing indicative evidence, but very helpful for confirming intestinal obstruction

ヒト大動脈粥状硬化におけるマトリックスメタロプテアーゼの免疫組織化学的および生化学的研究

取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1203号, 学位授与年月日：平成8年3月18日,学位授与年：199

High Efficiency Inverter Scroll Compressors

We have developed 8HP ~ 20HP high efficiency and high reliability , high-pressure dome type inverter scroll compressors , which are for the building air conditioning use,  to meet the recent increasing energy-saving demand. In addition to the traditional technology, which we employed to achieve high efficiency and high reliability, such as, -The high-low pressure dome structure to suppress the suction overheat - The push-back structure to suppress the increase in the surface pressure by introducing the high pressure oil between thrust sliding surface of the fixed scroll and the orbiting scroll, in this compressors we employed the following technology as well. - The optimization of the orbiting scroll back pressure in order to prevent the turnover of the orbiting scroll even at a low compression ratio operation, - Injection mechanism employing a check valve to achieve high efficiency both at rated condition and a low compression ratio condition, minimizing the dead volume of the compression chamber. Furthermore for the compressors, which are more than 16HP, · The balance mechanism, which suppress the deflection of shaft due to the gas load during the compression and prevent uneven contact of the shaft and the bearing, was adopted. With the new technologies above, as compared with the conventional scroll compressor, in a wide operation range from a low compression ratio operation to high compression ratio operation and from low-speed operation to high speed operation, efficiency and reliability were significantly improved in the APF and IPLV conditions In this paper I describe particularly about high-efficiency technology

Regulation of autophagy by nucleoporin Tpr

The nuclear pore complex (NPC) consists of a conserved set of ∼30 different proteins, termed nucleoporins, and serves as a gateway for the exchange of materials between the cytoplasm and nucleus. Tpr (translocated promoter region) is a component of NPC that presumably localizes at intranuclear filaments. Here, we show that Tpr knockdown caused a severe reduction in the number of nuclear pores. Furthermore, our electron microscopy studies indicated a significant reduction in the number of inner nuclear filaments. In addition, Tpr siRNA treatment impaired cell growth and proliferation compared to control siRNA-treated cells. In Tpr-depleted cells, the levels of p53 and p21 proteins were enhanced. Surprisingly, Tpr depletion increased p53 nuclear accumulation and facilitated autophagy. Our study demonstrates for the first time that Tpr plays a role in autophagy through controlling HSP70 and HSF1 mRNA export, p53 trafficking with karyopherin CRM1, and potentially through direct transcriptional regulation of autophagy factors. © 2012 Macmillan Publishers Limited. All rights reserved

Effects of Neodymium-Doped Yttrium Aluminium Garnet (Nd:YAG) Laser Irradiation on Bone Metabolism During Tooth Movement

Introduction: The aim of this study is to evaluate the effects of low-level neodymium-doped yttrium aluminium garnet (Nd:YAG) laser irradiation on orthodontic tooth movement and histological examination.Methods: Eleven male Wistar rats (aged 10 weeks) were included. To produce experimental tooth movement in rats, 10 g force was applied to maxillary first molars with nickel titanium closed coil springs. Right molars were irradiated with Nd:YAG laser on days 0, 1, 2, 3, 7, 10, 14, 17, 21 and 24, while un-irradiated left molars were used as control. Distance between mesial side of second molar and distal side of first molar was measured on μCT image during tooth movement and the rats were sacrificed 4 weeks after the initiation of tooth movement.Results: The amount of tooth movement was significantly greater in the irradiation group (0.20 ± 0.06) than in the control group (0.14 ± 0.03) during the first week (P < 0.05). However, no statistically significant difference was found afterwards. There was a tendency of higher tartrate-resistant acid phosphatase (TRAP)-positive nuclei count in the pressure zones of the laser irradiation group, but it was not statistically significant. In immuno-histological examination, expressions of alkaline phosphatase (ALP) and receptor activator of nuclear factor kappa-B ligand (RANKL) were higher at the pressure site of the laser irradiation group than the control group, whereas there was no difference in osteoprotegerin (OPG) expression.Conclusion: The results suggest that low-level Nd:YAG laser may stimulate osteoclast and osteoblast activation and accelerate bone metabolism during tooth movement

TONS504-PHOTODYNAMIC THERAPY INDUCES CYTOTOXIC EFFECTS IN EMT6 CELLS

In the present study, TONS504 (C51H58N8O5I2; molecular weight, 1,116.9), a novel cationic hydrophilic photosensitizer, was synthesized from protoporphyrin IX dimethyl ester through a five‑step process according to a patented method for use in photodynamic therapy (PDT). The subcellular localization of TONS504 and the cytotoxic effects of TONS504‑mediated PDT in the mouse mammary tumor EMT6 cell line were investigated. TONS504 was localized primarily in the lysosomes and partially in the mitochondria. The cytotoxic effects of TONS504‑mediated PDT in the mouse mammary tumor EMT6 cell line were investigated using a WST8 assay and an Oxidative Stress kit. The cell viability values following treatment with 10 µg/ml TONS504 at light energies of 0, 1, 5 and 10 J/cm2 were 92.5, 101.8, 27.7 and 1.8%, respectively. The percentages of reactive oxygen species (ROS)(+) cells following the same treatment were 8.6, 8.5, 29.2 and 70.1%, respectively, whereas the percentages of apoptotic cells were 7.1, 5.6, 24.8 and 48.7%, respectively. The percentages of ROS(+) and apoptotic cells in the group subjected to TONS504‑mediated PDT increased in a manner dependent on the TONS504 concentration and light energy. Further studies are required to evaluate the in vivo pharmacokinetics, tissue distribution and photodynamic effects of TONS504

Claw length recommendations for dairy cow foot trimming

The aim was to describe variation in length of the dorsal hoof wall in contact with the dermis for cows on a single farm, and hence, derive minimum appropriate claw lengths for routine foot trimming. The hind feet of 68 Holstein-Friesian dairy cows were collected post mortem, and the internal structures were visualised using x-ray mCT. The internal distance from the proximal limit of the wall horn to the distal tip of the dermis was measured from crosssectional sagittal images. A constant was added to allow for a minimum sole thickness of 5 mm and an average wall thickness of 8 mm. Data were evaluated using descriptive statistics and two-level linear regression models with claw nested within cow. Based on 219 claws, the recommended dorsal wall length from the proximal limit of hoof horn was up to 90 mm for 96 per cent of claws, and the median value was 83 mm. Dorsal wall length increased by 1 mm per year of age, yet 85 per cent of the null model variance remained unexplained. Overtrimming can have severe consequences; the authors propose that the minimum recommended claw length stated in training materials for all Holstein-Friesian cows should be increased to 90 mm