Instability of brane cosmological solutions with flux compactifications

We discuss the stability of the higher-dimensional de Sitter (dS) brane solutions with two-dimensional internal space in the Einstein-Maxwel theory. We show that an instability appears in the scalar-type perturbations with respect to the dS spacetime. We derive a differential relation which has the very similar structure to the ordinary laws of thermodynamics as an extension of the work for the six-dimensional model [20]. In this relation, the area of dS horizon (integrated over the two internal dimensions) exactly behaves as the thermodynamical entropy. The dynamically unstable solutions are in the thermodynamically unstable branch. An unstable dS compactification either evolves toward a stable configuration or two-dimensional internal space is decompactified. These dS brane solutions are equivalent to the accelerating cosmological solutions in the six-dimensional Einstein-Maxwell-dilaton theory via dimensional reduction. Thus, if the seed higher-dimensional solution is unstable, the corresponding six-dimensional solution is also unstable. From the effective four-dimensional point of view, a cosmological evolution from an unstable cosmological solution in higher dimensions may be seen as a process of the transition from the initial cosmological inflation to the current dark energy dominated Universe.Comment: 11 pages, 3 figures, references added, to appear in CQ

Early prediction of COVID-19 outcome using artificial intelligence techniques and only five laboratory indices

We aimed to develop a prediction model for intensive care unit (ICU) hospitalization of Coronavirus disease-19 (COVID-19) patients using artificial neural networks (ANN). We assessed 25 laboratory parameters at first from 248 consecutive adult COVID-19 patients for database creation, training, and development of ANN models. We developed a new alpha-index to assess association of each parameter with outcome. We used 166 records for training of computational simulations (training), 41 for documentation of computational simulations (validation), and 41 for reliability check of computational simulations (testing). The first five laboratory indices ranked by importance were Neutrophil-to-lymphocyte ratio, Lactate Dehydrogenase, Fibrinogen, Albumin, and D-Dimers. The best ANN based on these indices achieved accuracy 95.97%, precision 90.63%, sensitivity 93.55%. and F1-score 92.06%, verified in the validation cohort. Our preliminary findings reveal for the first time an ANN to predict ICU hospitalization accurately and early, using only 5 easily accessible laboratory indices

Perturbations of Gauss-Bonnet Black Strings in Codimension-2 Braneworlds

We derive the Lichnerowicz equation in the presence of the Gauss-Bonnet term. Using the modified Lichnerowicz equation we study the metric perturbations of Gauss-Bonnet black strings in Codimension-2 Braneworlds.Comment: 26 pages, no figures, clarifying comments and one reference added, to be published in JHE

Geometrothermodynamics in Horava-Lifshitz gravity

We investigate the thermodynamic geometries of the most general static, spherically symmetric, topological black holes of the Ho\v{r}ava--Lifshitz gravity. In particular, we show that a Legendre invariant metric derived in the context of geometrothermodynamics for the equilibrium manifold reproduces correctly the phase transition structure of these black holes. Moreover, the limiting cases in which the mass, the entropy or the Hawking temperature vanish are also accompanied by curvature singularities which indicate the limit of applicability of the thermodynamics and the geometrothermodynamics of black holes. The Einstein limit and the case of a black hole with flat horizon are also investigated.Comment: Preliminary draf

Nitrosative and Oxidative Stresses Contribute to Post-Ischemic Liver Injury Following Severe Hemorrhagic Shock: The Role of Hypoxemic Resuscitation

Purpose: Hemorrhagic shock and resuscitation is frequently associated with liver ischemia-reperfusion injury. The aim of the study was to investigate whether hypoxemic resuscitation attenuates liver injury. Methods: Anesthetized, mechanically ventilated New Zealand white rabbits were exsanguinated to a mean arterial pressure of 30 mmHg for 60 minutes. Resuscitation under normoxemia (Normox-Res group, n = 16, PaO2 = 95–105 mmHg) or hypoxemia (Hypox-Res group, n = 15, PaO 2 = 35–40 mmHg) followed, modifying the FiO 2. Animals not subjected to shock constituted the sham group (n = 11, PaO 2 = 95–105 mmHg). Indices of the inflammatory, oxidative and nitrosative response were measured and histopathological and immunohistochemical studies of the liver were performed. Results: Normox-Res group animals exhibited increased serum alanine aminotransferase, tumor necrosis factor- alpha, interleukin (IL)-1b and IL-6 levels compared with Hypox-Res and sham groups. Reactive oxygen species generation, malondialdehyde formation and myeloperoxidase activity were all elevated in Normox-Res rabbits compared with Hypox-Res and sham groups. Similarly, endothelial NO synthase and inducible NO synthase mRNA expression was up-regulated and nitrotyrosine immunostaining increased in animals resuscitated normoxemically, indicating a more intense nitrosative stress. Hypox-Res animals demonstrated a less prominent histopathologic injury which was similar to sham animals. Conclusions: Hypoxemic resuscitation prevents liver reperfusion injury through attenuation of the inflammatory respons