The effect of the antioxidant drug U-74389G on endometrial edema during ischemia reperfusion injury in rats

The aim of this experiment was to study the effects of the antioxidant drug U-74389G on rat model, particularly in ischemia reperfusion (IR) protocol. The beneficial or other effects of that molecule were studied pathologically using endometrial edema (EE) lesions. Forty rats were used of mean weight 231.875 gr. EE lesions were evaluated 60 min after reperfusion (groups A and C) and 120 min after reperfusion (groups B and D), with administration of the drug U-74389G in groups C and D. Results were that U-74389G administration non-significantly decreased without lesions the EE scores by 0.41 [-1.00 - 0.17] (p= 0.1607). This finding was in accordance with the results of Wilcoxon signed-rank test (p= 0.5229). Reperfusion time non-significantly increased without lesions the EE scores by 0.21 [-0.38 - 0.81] (p= 0.4701), also in accordance with Wilcoxon signed-rank test (p= 0.1022). However, U-74389G administration and reperfusion time together non-significantly decreased without lesions the EE scores by 0.17 [-0.53 - 0.18] (p= 0.3383). Results of this study indicate that U-74389G administration hardly non-significantly decreases without lesions the EE within short-term time context of 2 hours

The acute effect of the antioxidant drug “U-74389G” on mean platelet volume levels during hypoxia reoxygenation injury in rats

AbstractBackgroundThis experimental study examined the effect of the antioxidant drug “U-74389G”, on a rat model and particularly in a hypoxia – reoxygenation protocol. The effects of that molecule were studied hematologically using blood mean platelets volume (MPV) levels.Methods40 rats of mean weight 231.875g were used in the study. MPV levels were measured at 60min of reoxygenation (groups A and C) and at 120min of reoxygenation (groups B and D). The drug U-74389G was administered only in groups C and D.ResultsU-74389G administration kept significantly increased the predicted MPV levels by 12.77±3.07% (p=0.0001). Reoxygenation time non-significantly decreased the predicted MPV levels by 2.55±3.71% (p=0.4103). However, U-74389G administration and reoxygenation time together kept significantly increased the predicted MPV levels by 7.09±1.91% (p=0.0005).ConclusionsU-74389G administration whether it interacted or not with reoxygenation time kept significantly increased the predicted MPV levels. This finding has great clinical interest in blood clotting and coagulation pathophysiology

The effect of the antioxidant drug “U-74389G†on testosterone levels during ischemia reperfusion injury in rats

Background: This experimental study examined the effect of the antioxidant drug “U-74389Gâ€, on a rat model and particularly in an adrenal ischemia - reperfusion protocol. The effects of that molecule were studied biochemically using blood mean testosterone (T) levels.Materials and methods: 40 rats of mean weight 231.875 g were used in the study. Testosterone levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D), A and B without but C and D with U-74389G administration.Results: U-74389G administration significantly increased the T levels by 52.17%+28.69% (p=0.0451). Reperfusion time significantly decreased the T levels by 85.62%+26.33% (P= 0.0019). However, U-74389G administration and reperfusion time together produced a non-significant combined effect in increasing the T levels by 11.18%+17.97% (p= 0.5245).Conclusions: U-74389G administration interacted or not with reperfusion time increased short – term the testosterone levels.        Â

The effect of erythropoietin on ovarian epithelium edema during ischemia reperfusion injury in rats

Object: This experiment investigated a probable recessing effect of erythropoietin (Epo) in a rat model of ovarian ischemia-reperfusion (IR) injury concerning the mean ovarian epithelium edema (OE) lesions. Methods: 40 rats of mean weight 247.7 g were used totally. The OE lesions scores were evaluated at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion; after Epo administration in groups C and D. Results: Epo administration non-significantly decreased the OE scores by 0.3 without lesions [-0.8356043 - 0.2356043] (p= 0.2803). Reperfusion time kept non-significantly increased the OE by 0.35 without lesions [-0.2356043 - 0.8356043] (p=0.2557). However, erythropoietin administration and reperfusion time together non-significantly decreased the OE scores by 0.1272727 without lesions [-0.4530022 - 0.1984567] (p=0.4339). Conclusion: Epo administration showed a non-significant short-term recessing trend for OE scores without lesions alteration. Perhaps, a longer study time than 2 hours or a higher Epo dosage may reveal clearer and significant effects. &nbsp

The effect of erythropoietin on serum uric acid levels during renal ischemia reperfusion injury in rats

Objective: The aim of this experimental study was to assess the effect of erythropoietin on a rat model, particularly under a renal ischemia reperfusion protocol. The beneficial or lack of effects of that molecule on the excreted renal product of serum uric acid were studied biochemically. Material and methods: Forty rats were used with a mean weight of 247.7 gr. Serum uric acid levels were measured measured at 60 min after reperfusion (Groups A and C) and at 120 min after reperfusion (groups B and D). Results: 1) Erythropoietin administration non-significantly decreased the serum uric acid levels non-significantly by 0.02 mg/dL [-0.2415423 mg/dL-0.2015423 mg/dL] (p=0.8560), in accordance with the paired t-test (p=0.8438). Reperfusion time non-significantly increased the serum uric acid levels non-significantly by 0.17 mg/dL [-0.0444933 mg/dL-0.3844933 mg/dL] (p=0.1169), in accordance with the paired t-test (p=0.1648). 3) The interaction of erythropoietin administration and reperfusion time non-significantly increased the serum uric acid levels non-significantly by 0.1 mg/dL [-0.0295564 mg/dL-0.2295564 mg/dL] (p=0.1264). Conclusion: Erythropoietin administration, reper fusion time and their interaction have no significant short-term alterations on serum uric acid levels. Conclusions cannot be extracted by non-significant p-values within 2 hours. Obviously, longer study times may permit safer results. © 2014 by Turkish Association of Urology

The effect of erythropoietin on progesterone levels during ischemia reperfusion injury in rats

The aim of this experiment was to study the effects of erythropoietin on rat model, particularly in ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean blood progesterone levels. Materials and methods: Forty rats were used of mean weight 247.7 gm. Progesterone levels were measured 60 minutes after reperfusion for groups A and C and 120 minutes after reperfusion for groups B and D. Groups A and B without the drug but C and D with erythropoietin administration. Results: That erythropoietin administration nonsignificantly increased the progesterone levels by 4.235501 nmol/l (-13.07804 nmol/l-21.54904 nmol/l) (p = 0.6233). This finding was in accordance with the results of paired t-test (p = 0.6724). Reperfusion time nonsignificantly decreased the progesterone levels by-0.2034999 nmol/l (-17.5727 nmol/l-17.1657 nmol/l) (p = 0.9812), also in accordance with paired t-test (p = 0.9821). However, erythropoietin administration and reperfusion time together nonsignificantly increased the progesterone levels by 1.713364 nmol/l (-8.74561 nmol/l-12.17234 nmol/l) (p = 0.7420). Conclusion: Results of this study indicate that Epo decreases the predicted progesterone levels by 4.7 to 8.8%. This decreasing effect although non-significant is reinforced along time. Perhaps, a longer study time than 2 hours may provide clearer and significant effect. © 2014, Jaypee Brothers Medical Publishers (P) Ltd. All rights reserved

The effect of the antioxidant drug “U-74389G” on creatine phosphokinase levels during ischemia reperfusion injury in rats

Objective: This experimental study examines the effect of the antioxidant drug “U-74389G” on rat model, particularly in an ischemia–reperfusion (IR) protocol. The effects of this molecule were biochemically studied using mean creatinine phosphokinase (CPK) levels in blood. Materials and Methods: Forty rats with a mean weight of 231.875 g were used in the study. CPK levels were measured at 60 min (groups A and C) and at 120 min of reperfusion (groups B and D); A and B were groups without U-74389G administration,but C and D were groups with U-74389G administration. Results: U-74389G administration significantly increased CPK levels by 35.34%+17.20% (p=0.0260). Reperfusion time nonsignificantly increased CPK levels by 13.17%+18.05% (p=0.4134). However, U-74389G admi nistration and reperfusion timetogether non-significantly increased CPK levels by 18.52%+9.44% (p=0.0770). Conclusion: U-74389G administration significantly increased CPK levels for a short term; however, these levels could not be restored, and the restoration capacity increases along with reperfusion time. © 2015 by Erciyes University School of Medicine

The effect of the antioxidant drug "U-74389G" on alkaline phosphatase levels during ischemia reperfusion injury in rats

The aim of this experimental study was to examine the effect of the antioxidant drug "U-74389G", on rat model and particularly in a liver ischemia reperfusion (IR) protocol. The beneficial effect or non-effectiveness of that molecule were studied biochemically using mean blood alkaline phosphatase levels (ALP). Forty rats of mean weight 231.875 gr were used in the study. ALP levels were measured 60 min after reperfusion (groups A and C) and 120 min after reperfusion (groups B and D) with administration of the drug U-74389G in groups C and D. U-74389G administration non-significantly increased the ALP levels by 19.76%±15.06% (p=0.1784), but by 31.91%±7.69% (p=0.0001) for predicted values. Reperfusion time non-significantly decreased the ALP levels by 25.21%±14.83% (p=0.0675), also by 6.38%±9.30% (p=0.3650) for predicted values. However, U-74389G administration and reperfusion time together non-significantly increased the ALP levels by 8.08%±9.19% (p=0.3696), but also by 17.75%±4.79% (p=0.0005) for predicted values. This study indicates that U-74389G administration and its interaction with reperfusion time non-significantly increased short-term effects on ALP levels. However, the predicted ALP values adjusted for rats weight, kept significantly increased ones, which stand for the restorating effects of U-74389G, that are slower than it seems. © 2014 OMU