Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome

AbstractIschemic stroke (IS) outcome predictors include clinical features, biochemical parameters and some risk factors. The relations between two main players in the ischemic brain, MMPs and HMGB1, were estimated in the plasma of ischemic stroke patients stratified according to the Glasgow Outcome Scale and the Oxfordshire Community Stroke Project classification. IS patients exhibited higher plasma concentration of MMP-9 and the inflammatory cytokine HMGB1 compared with healthy controls. A full-blown correlation between MMP-9 activation and increased plasma MMP-9 concentration was observed in case of IS patients. A similar activity of MMP-2 and MMP-12 was characteristic of healthy volunteers and IS patients. In patients with ischemic stroke increased plasma levels of MMP-9 and HMGB1 are associated with a poor functional outcome and are significantly correlated with each other (P=0.0054). We suggest that diagnostic benefits will be obtained if plasma HMGB1 levels are measured for IS patients in addition to MMP-9

Incidence rates of the primary brain tumours in Georgia - a population-based study

BACKGROUND: To determine the incidence rate and to describe other basic epidemiological data of primary brain tumours in a population-based study in Georgia, performed between March 2009 and March 2011. METHODS: Active case ascertainment was used to identify brain tumour cases by searching neuroradiology scan reports and medical records from all participating medical institutions, covering almost 100% of the neurooncology patients in the country. RESULTS: A total of 980 new cases were identified during the two-year period. For a population of almost 4.5 million, the overall annual incidence rate was 10.62 per 100,000 person-years, age-standardized to the year 2000 US population (ASR). Non-malignant tumours constituted about 65.5% of all tumours. Males accounted for 44% and females for 56% of the cases. Among classified tumours, age-standardized incidence rates by histology were highest for meningiomas (2.65/100,000), pituitary adenoma (1.23/100,000) and glioblastomas (0.51/100,000). ASR were higher among females than males for all primary brain tumours (10.35 vs. 9.48/100,000) as well as for main histology groups except for neuroepithelial, lymphomas and germ cell tumours. CONCLUSIONS: The annual incidence rate of all primary brain tumours in Georgia, though comparable with some European registry data, is low in comparison with the 2004–2005 Central Brain Tumor Registry of the United States (CBTRUS) database, which may reflect variations in reporting and methodology. The higher percentage of unclassified tumours (37.8%) probably also affects the discrepancies between our and CBTRUS findings. However, the most frequently reported tumour was meningioma with a significant predominance in females, which is consistent with CBTRUS data

Poly(ester amide) microspheres are efficient vehicles for long-term intracerebral growth factor delivery and improve functional recovery after stroke

Growth factors promote plasticity in injured brain and improve impaired functions. For clinical application, efficient approaches for growth factor delivery into the brain are necessary. Poly(ester amide) (PEA)-derived microspheres (MS) could serve as vehicles due to their thermal and mechanical properties, biocompatibility and biodegradability. Vascular endothelial growth factor (VEGF) exerts both vascular and neuronal actions, making it suitable to stimulate post-stroke recovery. Here, PEA (composed of adipic acid, L-phenyl-alanine and 1,4-butanediol) MS were loaded with VEGF and injected intracerebrally in mice subjected to cortical stroke. Loaded MS provided sustained release of VEGF in vitro and, after injection, biologically active VEGF was released long-term, as evidenced by high VEGF immunoreactivity, increased VEGF tissue levels, and higher vessel density and more NG2+ cells in injured hemisphere of animals with VEGF-loaded as compared to non-loaded MS. Loaded MS gave rise to more rapid recovery of neurological score. Both loaded and non-loaded MS induced improvement in neurological score and adhesive removal test, probably due to anti-inflammatory action. In summary, grafted PEA MS can act as efficient vehicles, with anti-inflammatory action, for long-term delivery of growth factors into injured brain. Our data suggest PEA MS as a new tool for neurorestorative approaches with therapeutic potential

Conflict resolution

This thesis proposes a new method for solving systems of linear constraints over the rational and real numbers (or, equivalently, linear programming) - the conflict resolution method. The method is a new approach to a classic problem in mathematics and computer science, that has been known since the 19th century. The problem has a wide range of real-life applications of increasing importance in both academic and industrial areas. Although, the problem has been a subject of intensive research for the past two centuries only a handful of methods had been developed for solving it. Consequently, new results in this field may be of particular value, not mentioning the development of new approaches. The motivation of our research did not arise solely from the field of linear programming, but rather was instantiated from problems of Satisfiability Modulo Theories (or shortly SMT). SMT is a new and rapidly developing branch of automated reasoning dedicated to reasoning in first-order logic with (combination) of various theories, such as, linear real and integer arithmetic, theory of arrays, equality and uninterpreted functions, and others. The role of linear arithmetic in solving SMT problems is very significant, since a considerable part of SMT problems arising from real-life applications involve theories of linear real and integer arithmetic. Reasoning on such instances incorporates reasoning in linear arithmetic. Our research spanned the fields of SMT and linear programming. We propose a method, that is not only used for solving linear programming problems, but also is well-suited to SMT framework. Namely, there are certain requirements imposed on theory reasoners when they are integrated in SMT solving. Our conflict resolution method possesses all the attributes necessary for integration into SMT. As the experimental evaluation of the method has shown, the method is very promising and competitive to the existing ones.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Stroke care indicators in the Republic of Moldova – the RES-Q registry

Introducere. Până la aderarea Moldovei in anul 2016 la platforma internațională RES-Q (Registry of Stroke Care Quality) - Registrul Calității Îngrijirii Accidentului Vascular Cerebral (AVC), nu au existat date privind indicatorii de calitate intraspitalicești ai ictusului. Scopul acestei lucrări a fost de a evalua calitatea asistenței medicale acordată pacienților cu AVC în Moldova în baza datelor registrului RES-Q. Material și metode. Au fost analizate datele tuturor pacienților cu ictus ischemic și hemoragic acut din registrul RES-Q din 15 spitale din Moldova. Datele au fost colectate timp de o lună pe an pe parcurs a 3 ani (2017-2019). Analiza datelor între spitale s-a realizat din considerentul accesului acestora la computer tomografia cerebrală. Adițional, datele din Moldova au fost comparate cu cele din trei țări ale proiectului ESO-EAST (European Stroke Organization Enhancing and Accelerating Stroke Treatment): România, Lituania și Georgia. Rezultate. Studiul a inclus un număr total de 1660 pacienți, cu vârsta medie de 68 ani (49% - bărbați). Moldova a înregistrat rezultate mai slabe la numărul de CT efectuate (81% [95% CI 79-84%]), la evaluarea disfagiei (29% [95% CI 27-32%]), efectuarea trombolizei intravenoase (3% [95% CI 2-4%]), administrarea de anticoagulante (44% [95% CI 39-49%]) și statine (42% [95% CI 39-45%]) la externare, la mortalitatea intraspitalicească prin AVC (17% [95% CI 15- 19%]). În interiorul Moldovei calitatea asistenței prin AVC s-a comparat reieșind din accesul la CT. Concluzii. Studiul nostru a identificat lacune serioase ale performanțelor asistenței intraspitalicești în ictus, cum ar fi lipsa scanărilor prin CT în multe spitale publice, absența unei rețele naționale centralizate în domeniul AVC, acces extrem de scăzut la tratamentul prin tromboliză și implementarea nesatisfăcătoare a tratamentului de profilaxie secundară a ictusului.Introduction. There were no data on in-hospital stroke care indicators until Moldova’s accession to the international Registry of Stroke Care Quality (RES-Q) platform in 2016. The aim of this paper was to assess the acute stroke care quality in Moldova based on the data of the RES-Q registry. Material and methods. We analyzed the data of all patients with acute ischemic and hemorrhagic stroke of the RES-Q from 15 Moldovan hospitals. Data were collected for one month each year, during a 3-year period (2017-2019). Data analysis was performed between hospitals according to their access to a brain CT facility for Moldovan participating hospitals. Additionally, Moldovan data were compared with other three ESO-EAST (European Stroke Organization Enhancing and Accelerating Stroke Treatment) project countries: Romania, Lithuania, and Georgia. Results. A total of 1660 patients were recruited in the study, mean age of 68 years (49% men). Moldova registered poorer results in number of brain CT performed (81% [95% CI 79-84%]), dysphagia screening (29% [95% CI 27-32%]), IV thrombolysis performed (3% [95% CI 2-4%]), administration of anticoagulants (44% [95% CI 39-49%]) and statins (42% [95% CI 39-45%]) at discharge, in-hospital stroke mortality (17% [95% CI 15- 19%]). Within Moldova the stroke care quality was driven by the access to CT scan. Conclusions. Our study highlighted some serious gaps of in-hospital stroke care performance in Moldova, such as the lack of CT scans in many public hospitals, the absence of a national stroke center network, extremely low accessibility of IV thrombolysis and unsatisfactory implementation of secondary stroke prevention treatment

Stroke incidence and 30-day case-fatality in a suburb of Tbilisi: results of the first prospective population-based study in Georgia

BACKGROUND AND PURPOSE: Although stroke is one of the main public health problems worldwide, no study of stroke incidence has been performed in Georgia, and therefore, a population-based registry was established to determine the incidence and case-fatality rates of first-ever stroke. METHODS: We identified all first-ever strokes between November 2000 and July 2003 in a defined population of 51,246 residents in the Sanzona suburb of Tbilisi, the capital of Georgia, using overlapping sources of information and standard diagnostic criteria. RESULTS: A total of 233 first-ever strokes occurred during the study period. The crude annual incidence rate was 165 (95% CI, 145 to 188) per 100,000 residents. The corresponding rate adjusted to the standard "world" population was 103 (95% CI, 89 to 117). In terms of stroke subtype, the crude annual incidence rate per 100,000 inhabitants was 89 (95% CI, 74 to 106) for ischemic stroke, 44 (95% CI, 34 to 57) for intracerebral hemorrhage, 16 (95% CI, 10 to 25) for subarachnoidal hemorrhage, and 16 (95% CI, 10 to 25) for unspecified stroke, and the corresponding case-fatality rates at 1 month were 19.2%, 48.4%, 47.8%, and 69.6%. CONCLUSIONS: The overall stroke incidence rate in an urban population of Georgia is comparable to those reported in developed countries. As for the stroke subtypes, there is an excess of hemorrhagic strokes compared with other registries. Geographical and lifestyle variations may explain these findings, whereas inadequacy of the stroke care system in Georgia might contribute to the high case-fatality. [Authors]]]> Cerebrovascular Accident oai:serval.unil.ch:BIB_31770 2022-05-07T01:14:25Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_31770 La résurrection du Christ dans les apocryphes. Gounelle, R info:eu-repo/semantics/bookPart incollection 2004 Les premiers temps de l'Église. De saint Paul à saint Augustin (Folio Histoire 124), pp. 117-121 Baslez, M-F (ed.) oai:serval.unil.ch:BIB_31771 2022-05-07T01:14:25Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_31771 Le Christ des apocryphes. Gounelle, R info:eu-repo/semantics/bookPart incollection 2004 Les premiers temps de l'Église. De saint Paul à saint Augustin (Folio Histoire 124), pp. 242-245 Baslez, M-F (ed.) oai:serval.unil.ch:BIB_31771256CC87 2022-05-07T01:14:25Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_31771256CC87 Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. info:doi:10.1016/S2213-8587(14)70102-0 info:eu-repo/semantics/altIdentifier/doi/10.1016/S2213-8587(14)70102-0 info:eu-repo/semantics/altIdentifier/pmid/24842598 Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration Danaei, G. Lu, Y. Singh, G.M. Carnahan, E. Stevens, G.A. Cowan, M.J. Farzadfar, F. Lin, J.K. Finucane, M.M. Rao, M. Khang, Y.H. Riley, L.M. Mozaffarian, D. Lim, S.S. Ezzati, M. Aamodt, G. Abdeen, Z. Abdella, N.A. Rahim, H.F. Addo, J. Aekplakorn, W. Afifi, M.M. Agabiti-Rosei, E. Salinas, C.A. Agyemang, C. Ali, M.K. Ali, M.M. Al-Nsour, M. Al-Nuaim, A.R. Ambady, R. Di Angelantonio, E. Aro, P. Azizi, F. Babu, B.V. Bahalim, A.N. Barbagallo, C.M. Barbieri, M.A. Barceló, A. Barreto, S.M. Barros, H. Bautista, L.E. Benetos, A. Bjerregaard, P. Björkelund, C. Bo, S. Bobak, M. Bonora, E. Botana, M.A. Bovet, P. Breckenkamp, J. Breteler, M.M. Broda, G. Brown, I.J. Bursztyn, M. de León, A.C. Campos, H. Cappuccio, F.P. Capuano, V. Casiglia, E. Castellano, M. Castetbon, K. Cea, L. Chang, C.J. Chaouki, N. Chatterji, S. Chen, C.J. Chen, Z. Choi, J.S. Chua, L. Cífková, R. Cobiac, L.J. Cooper, R.S. Corsi, A.M. Costanza, M.C. Craig, C.L. Dankner, R.S. Dastgiri, S. Delgado, E. Dinc, G. Doi, Y. Dong, G.H. Dorsi, E. Dragano, N. Drewnowski, A. Eggertsen, R. Elliott, P. Engeland, A. Erem, C. Esteghamati, A. Fall, C.H. Fan, J.G. Ferreccio, C. Fezeu, L. Firmo, J.O. Florez, H.J. Fornés, N.S. Fowkes, F.G. Franceschini, G. Frisk, F. Fuchs, F.D. Fuller, E.L. Getz, L. Giampaoli, S. Gómez, L.F. Gomez-Zumaquero, J.M. Graff-Iversen, S. Grant, J.F. Carvajal, R.G. Gulliford, M.C. Gupta, R. Gupta, P.C. Gureje, O. Gutierrez, H.R. Hansen, T.W. Hata, J. He, J. Heim, N. Heinrich, J. Hemmingsson, T. Hennis, A. Herman, W.H. Herrera, V.M. Ho, S. Holdsworth, M. Frisman, G.H. Hopman, W.M. Hussain, A. Husseini, A. Ibrahim, M.M. Ikeda, N. Jacobsen, B.K. Jaddou, H.Y. Jafar, T.H. Janghorbani, M. Jasienska, G. Joffres, M.R. Jonas, J.B. Kadiki, O.A. Kalter-Leibovici, O. Kamadjeu, R.M. Kaptoge, S. Karalis, I. Kastarinen, M.J. Katz, J. Keinan-Boker, L. Kelly, P. Khalilzadeh, O. Kiechl, S. Kim, K.W. Kiyohara, Y. Kobayashi, J. Krause, M.P. Kubínová, R. Kurjata, P. Kusuma, Y.S. Lam, T.H. Langhammer, A. Lawes, C.M. Le, C. Lee, J. Lévy-Marchal, C. Lewington, S. Li, Y. Li, Y. Lim, T.O. Lin, X. Lin, C.C. Lin, H.H. Lind, L. Lissner, L. Liu, X. Lopez-Jaramillo, P. Lorbeer, R. Ma, G. Ma, S. Macià, F. MacLean, D.R. Maggi, S. Magliano, D.J. Makdisse, M. Mancia, G. Mannami, T. Marques-Vidal, P. Mbanya, J.C. McFarlane-Anderson, N. Miccoli, R. Miettola, J. Minh, H.V. Miquel, J.F. Miranda, J.J. Mohamed, M.K. Mohan, V. Mohanna, S. Mokdad, A. Mollentze, W.F. Morales, D.D. Morgan, K. Muiesan, L.M. Muntoni, S. Nabipour, I. Nakagami, T. Nangia, V. Nemesure, B. Neovius, M. Nerhus, K.A. Nervi, F. Neuhauser, H. Nguyen, M. Ninomiya, T. Noale, M. Oh, S.W. Ohkubo, T. Olivieri, O. Önal, A.E. Onat, A. Oróstegui, M. Ouedraogo, H. Pan, W.H. Panagiotakos, D.B. Panza, F. Park, Y. Passos, V.M. Pednekar, M.S. Pelizzari, P.M. Peres, M.A. Pérez, C. Pérez-Fernández, R. Pichardo, R. Phua, H.P. Pistelli, F. Plans, P. Polakowska, M. Poulter, N. Prabhakaran, D. Qiao, Q. Rafiei, M. Raitakari, O.T. Ramos, L.R. Rampal, S. Rampal, L. Rasmussen, F. Reddy, K.K. Redon, J. Revilla, L. Reyes-García, V. Roaeid, R.B. Robinson, C.A. Rodriguez-Artalejo, F. Rojas-Martinez, R. Ronkainen, K. Rosero-Bixby, L. Roth, G.A. Sachdev, H.S. Sánchez, J.R. Sanisoglu, S.Y. Sans, S. Sarraf-Zadegan, N. Scazufca, M. Schaan, B.D. Schapochnik, N. Schelleman, H. Schneider, I.J. Schooling, C.M. Schwarz, B. Sekuri, C. Sereday, M.S. Serra-Majem, L. Shaw, J. Shera, A.S. Shi, Z. Shiri, R. Shu, X.O. Silva, D.A. Silva, E. Simons, L.A. Smith, M. Söderberg, S. Soebardi, S. Solfrizzi, V. Sonestedt, E. Soysal, A. Stattin, P. Stein, A.D. Stergiou, G.S. Stessman, J. Sudo, A. Suka, M. Sundh, V. Sundquist, K. Sundström, J. Swai, A.B. Tai, E.S. Tambs, K. Tesfaye, F. Thomas, G.N. Thorogood, M. Tilvis, R.S. Tobias, M. Torheim, L.E. Trenkwalder, P. Tuomilehto, J.O. Tur, J.A. Tzourio, C. Uhernik, A.I. Ukoli, F.A. Unwin, N. Hoorn, S.V. Vanderpump, M.P. Varo, J.J. Veierød, M.B. Velásquez-Meléndez, G. Verschuren, M. Viet, L. Villalpando, S. Vioque, J. Vollenweider, P. Volpato, S. Wang, N. Wang, Y.X. Ward, M. Waspadji, S. Welin, L.X. Whitlock, G. Wilhelmsen, L. Willeit, J. Woodward, M. Wormser, D. Xavier, A.J. Xu, F. Xu, L. Yamamoto, A. Yang, G. Yang, X. Yeh, L.C. Yoon, J.S. You, Q. Yu, Z. Zhang, J. Zhang, L. Zheng, W. Zhou, M. Ward, M. info:eu-repo/semantics/article article 2014-08</

Caracteristici epidemiologice ale leziunilor traumatice cerebrale dintr-un centrul medical național de ingrijire a traumatismelor de prim nivel din Georgia

Introduction. Traumatic brain injuries area significant public health issue in both developed and developing countries. In Georgia, traumatic brain injuries remain one of the leading causes of mortality and disability. Traumatic brain injuries affect families, communities and societies in Georgia and have far-reaching human, social and economic costs, manifested in increased emergency department visits, hospitalizations, disability and deaths. The aim of this study is to retrospectively analyze the epidemiological features of Traumatic Brain Injuries on the example of Medical Centre in Georgia which provides a first level trauma care for patients in the country. Material and methods. Retrospective observational study was con-ducted from August 1 to October 31, 2018. The study included patients who were admitted with a Traumatic Brain Injuries diagnosis and S00-S09.0 codes (ICD 10). SPSS 20 was used for statistical analysis. Results. A total of 96 TBI-related hospitalizations were studied. 56.3% (n=54) of hospitalized patients were males. The average age of patients was 40.7 years. Furthermore, patients aged 25-44 years were more represented in the number of TBI-related hospitalizations (39.6%). 95.8% of all Traumatic brain injuries hospitalizations were as a result of unintentional injuries. Unintentional falls were shown to be the predominant mechanism of injury accounting for over half of TBI-related hospitalizations (56.2%). The second most common mechanism of injury is the road traffic injury, mostly occurring among males (63.9%). Conclusions. This study offers an insight into understanding the epidemiological features of Traumatic Brain Injuries on the example of the National Medical Center from Georgia.Introducere. Leziunile cerebrale traumatice (LCT) reprezintă o problemă semnificativă de sănătate publică atât în țările dezvoltate, cât și în cele în curs de dezvoltare. În Georgia, leziunile cerebrale traumatice rămân una dintre principalele cauze de mortalitate și dizabilitate. Leziunile cerebrale traumatice afectează familiile, comunitățile și societățile din Georgia și au costuri umane, sociale și economice de anvergură, manifestate prin creșterea vizitelor la secțiile de urgență, spitalizări, dizabilități și decese. Scopul acestui studiu este de a analiza, retrospectiv, trăsăturile epidemiologice ale leziunilor cerebrale traumatice, în baza exemplului Centrului Medical din Georgia, care oferă un prim nivel de îngrijire a traumei, pacienților din țară. Material și metode. A fost realizat un studiul observațional retrospectiv în perioada 1 august – 31 octombrie 2018. Studiul a inclus pacienți care au fost internați cu diagnostic de leziuni cerebrale traumatice-codurile S00-S09.0 (ICD 10). Analiza statistică a datelor a fost realizată în SPSS 20. Rezultate. Au fost studiate 96 de spitalizări legate de LCT; 56,3% (n=54) dintre pacienții internați fiind bărbați. Vârsta medie a pacienților a fost de 40,7 ani. În plus, pacienții cu vârsta cuprinsă între 25-44 de ani au fost mai frecvenți în numărul de spitalizări legate de LCT (39,6%). 95,8% dintre toate spitalizările cu leziuni cerebrale traumatice au fost ca urmare a unor leziuni neintenționate. Căderile neintenționate s-au dovedit a fi mecanismul predominant de rănire, reprezentând peste jumătate din spitalizările legate de LCT (56,2%). Al doilea cel mai frecvent mecanism de rănire este vătămarea rutieră, care se înregistrează, mai ales, în rândul bărbaților (63,9%). Concluzii. Acest studiu oferă o perspectivă asupra înțelegerii caracteristicilor epidemiologice ale leziunilor cerebrale traumatice, în baza Centrului Medical Național din Georgia

Distribution and invasiveness of four non-native species of plants in ecosystems in the Chorokhi delta (SW Georgia)

Chorokhi Delta is known for its high diversity and many habitats, which however are being threatened by invasive plants. Here, the effects of four invasive species of plants, namely Ambrosia artemisiifolia, Sicyos angulatus, Solidago canadensis and Verbena brasiliensis were studied. These species were recorded in the coastal area of the Black Sea and in particular in Georgia for the first time in the first half of the last century and S. angulatus is a very recent arrival. Currently, these species constitute a significant threat to biodiversity at local, national and global levels. These invasive species were monitored from 2021 to 2022. During this period, sites with high densities of the invasive species were identified. For each species, 5 transects were randomly set, and along each of them, 10 plots (1 × 1 m) were surveyed. The density, frequency, coverage and average height of the invasive plants were measured in each plot. These measurements were recorded twice per year for two years (2021–2022). All this information will be used to develop management plans aimed at preventing their further spread or control their abundance. The results indicate that Ambrosia artemisiifolia is the most invasive and widely distributed. Verbena brasiliensis and Sicyos angulatus are also highly competitive species that can seriously affect semi-natural habitats in the Chorokhi Delta and in agricultural land located close to the Delta. Unlike these species, Solidago canadensis is not widely distributed in the area studied. However, its ability to survive in a wide range of habitats and clonal growth indicate that it is potentially a highly dangerous invasive species, which in the future is expected to expand its range and severely affect the semi-natural ecosystems and agricultural land in the Chorokhi Delta. The results of the present study demonstrate the high adaptability of the species studied and their potential for spreading further in the near future