20 research outputs found
Compressive sensing adaptation for polynomial chaos expansions
Basis adaptation in Homogeneous Chaos spaces rely on a suitable rotation of
the underlying Gaussian germ. Several rotations have been proposed in the
literature resulting in adaptations with different convergence properties. In
this paper we present a new adaptation mechanism that builds on compressive
sensing algorithms, resulting in a reduced polynomial chaos approximation with
optimal sparsity. The developed adaptation algorithm consists of a two-step
optimization procedure that computes the optimal coefficients and the input
projection matrix of a low dimensional chaos expansion with respect to an
optimally rotated basis. We demonstrate the attractive features of our
algorithm through several numerical examples including the application on
Large-Eddy Simulation (LES) calculations of turbulent combustion in a HIFiRE
scramjet engine.Comment: Submitted to Journal of Computational Physic
Congenital Nephrotic Syndrome in IL7Rα-SCID: A Rare Feature of Maternofetal Graft-Versus-Host Disease
info:eu-repo/semantics/publishedVersio
Hematopoietic Stem Cell Transplantation Resolves the Immune Deficit Associated with STAT3-Dominant-Negative Hyper-IgE Syndrome.
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadAutosomal dominant hyper-IgE syndrome caused by dominant-negative loss-of-function mutations in signal transducer and activator of transcription factor 3 (STAT3) (STAT3-HIES) is a rare primary immunodeficiency with multisystem pathology. The quality of life in patients with STAT3-HIES is determined by not only the progressive, life-limiting pulmonary disease, but also significant skin disease including recurrent infections and abscesses requiring surgery. Our early report indicated that hematopoietic stem cell transplantation might not be effective in patients with STAT3-HIES, although a few subsequent reports have reported successful outcomes. We update on progress of our patient now with over 18 years of follow-up and report on an additional seven cases, all of whom have survived despite demonstrating significant disease-related pathology prior to transplant. We conclude that effective cure of the immunological aspects of the disease and stabilization of even severe lung involvement may be achieved by allogeneic hematopoietic stem cell transplantation. Recurrent skin infections and abscesses may be abolished. Donor TH17 cells may produce comparable levels of IL17A to healthy controls. The future challenge will be to determine which patients should best be offered this treatment and at what point in their disease history.Job Research Foundation
Welsh Clinical Academic Training (WCAT) programme
German Research Foundation (DFG)
German Research Foundation (DFG)
Federal Ministry of Education & Research (BMBF)
Center for Chronic Immunodeficiency (CCI), Freiburg Center for Rare Diseases (FZSE