SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein

Proteolytic generation of amyloidogenic amyloid {beta} (A{beta}) fragments from the amyloid precursor protein (APP) significantly contributes to Alzheimer's disease (AD). Although amyloidogenic APP proteolysis can be affected by trafficking through genetically associated AD components such as SORLA, how SORLA functionally interacts with other trafficking components is yet unclear. Here, we report that SNX27, an endosomal trafficking/recycling factor and a negative regulator of the {gamma}-secretase complex, binds to the SORLA cytosolic tail to form a ternary complex with APP. SNX27 enhances cell surface SORLA and APP levels in human cell lines and mouse primary neurons, and depletion of SNX27 or SORLA reduces APP endosome-to-cell surface recycling kinetics. SNX27 overexpression enhances the generation of cell surface APP cleavage products such as soluble alpha-APP C-terminal fragment (CTF{alpha}) in a SORLA-dependent manner. SORLA-mediated A{beta} reduction is attenuated by downregulation of SNX27. This indicates that an SNX27/SORLA complex functionally interacts to limit APP distribution to amyloidogenic compartments, forming a non-amyloidogenic shunt to promote APP recycling to the cell surface

Study of W boson production in pPb collisions at √sNN = 5.02 TeV

The first study of W boson production in pPb collisions is presented, for bosons decaying to a muon or electron, and a neutrino. The measurements are based on a data sample corresponding to an integrated luminosity of 34.6 nb-1 at a nucleon-nucleon centre-of-mass energy of √sNN = 5.02 TeV, collected by the CMS experiment. The W boson differential cross sections, lepton charge asymmetry, and forward-backward asymmetries are measured for leptons of transverse momentum exceeding 25 GeV/c, and as a function of the lepton pseudorapidity in the |ηlab|<2.4 range. Deviations from the expectations based on currently available parton distribution functions are observed, showing the need for including W boson data in nuclear parton distribution global fits. © 2015 CERN for the benefit of the CMS Collaboration

Study of Z boson production in pPb collisions at √sNN=5.02 TeV

The production of Z bosons in pPb collisions at √sNN=5.02 TeV is studied by the CMS experiment via the electron and muon decay channels. The inclusive cross section is compared to pp collision predictions, and found to scale with the number of elementary nucleon–nucleon collisions. The differential cross sections as a function of the Z boson rapidity and transverse momentum are measured. Though they are found to be consistent within uncertainty with theoretical predictions both with and without nuclear effects, the forward–backward asymmetry suggests the presence of nuclear effects at large rapidities. These results provide new data for constraining nuclear parton distribution functions

PERSISTENCE PROBABILITY ANALYZED ON THE TAIWAN STOCK MARKET

We report a numerical study of the Taiwan stock market, in which we used three data sources: the daily Taiwan stock exchange index (TAIEX) from January 1983 to May 2006, the daily OTC index from January 1995 to May 2006, and the one-min intraday data from February 2000 to December 2003. Our study is based on numerical estimates of persistence exponent theta(p), Hurst exponent H(2), and fluctuation exponent h(2). We also discuss the results concerning persistence probability P(t), qth-order price-price correlation function G(q)(t), and qth-order normalized fluctuation function f(q)(t) among these indices

A persistence probability analysis in major financial indices

We analyzed twenty world stock market indices and compared the persistence properties among these countries. Two methods were used in the analyses: (1) the price-price correlation analysis technique and (2) the persistence analysis technique. Our studies are based on numerical estimates of the persistence exponent theta(p) and the Hurst exponent H-2, The relation theta(p) = 1 - H-2 among these countries is also discussed

The burrs formation prediction and minimization based on the optimal cutting parameters design method

Researches have shown the cutting parameters and the burrs formation are close related, but these relationships cannot be formed in a simple formula. The mechanism of burrs formation and its appearance occurred to the cutting material quite depends on the method of machining and cutting condition. Although the relationships are nonlinear, the residual burrs can be reduced significantly by selecting appropriate cutting parameters during machining. In this research, a series of cutting experiments that based on Taguchi experimental method has been conducted to explore the formation of burrs size and types under different cutting conditions. The relationship of cutting parameters and the burrs formation data are collected for further study. With the burr size as the evaluation index, cutting speed, feed-rate, and depth of cut are chosen to cut the medium carbon steel (S50C). The Taguchi Method and Artificial Neural Network are adapted to establish the burrs formation model, and then the neural network based on optimal design method as a tool in cutting parameters optimization is employed. The result shows the goal of reduce burrs size into a reasonable region can be accomplished by adjusting cutting parameters. The experiments proved the burrs size with the optimal design method can be reduced as much as 67 to 78% that comparing with experienced cutting condition. As this point of view, the parameters optimization operations by optimal parameters design method offer an effective tool to reduce the burrs size in machining

Semicontinuous microcosm study of aerobic cometabolism of trichloroethylene using toluene

A semicontinuous slurry- microcosm method was applied to mimic trichloroethylene (TCE) cometabolic biodegradation field results at the Que-Jen in-situ pilot study. The microcosm study confirmed the process of aerobic cometabolism of TCE using toluene as the primary substrate. Based on the nucleotide sequence of 16S rRNA genes, the toluene-oxidizing bacteria in microcosms were identified, i.e. Ralstonia sp. P-10 and Pseudomonas putida. The first-order constant of TCE-degradation rate was 0.5 day(-1) for both Ralstonia sp. P-10 and P putida. The TCE cometabolic-biodegradation efficiency measured from the slurry microcosms was 46%, which appeared pessimistic compared to over 90% observed from the in-situ pilot study. The difference in the TCE cometabolic-biodegradation efficiency was likely due to the reactor configurations and the effective time duration of toluene presence in laboratory microcosms (1 days) versus in-situ pilot study (3 days). The results of microcosm experiments using different toluene-injection schedules supported the hypothesis. With a given amount of toluene injection, it is recommended to maximize the effective time duration of toluene presence in reactor design for TCE cometabolic degradation. (C) 2007 Elsevier B.V. All rights reserved