159 research outputs found
A sustainable post-disaster housing development framework for an indigenous Hao-Cha community in Taiwan: considering culture and livelihood in housing extensions
[Purpose] Several post-disaster housing extension and modification studies have indicated that owner-driven modification behavior relates to socio-economic and livelihood factors. This study aims to clarify housing extension patterns and examine the relationships among spatial characteristics, sociocultural factors, livelihood factors and housing extensions. This research also highlights the implications of post-disaster housing design for indigenous communities. [Design/methodology/approach] An indigenous community case study was conducted using a literature review. Moreover, interview surveys and housing measurements were implemented based on purposive sampling to diversify interviewees’ backgrounds and the extent of housing extensions. [Findings] This study confirms that housing extensions are closely related to the number of household members and their associated functions and cultural and livelihood factors that were ignored during the design stage. Furthermore, the housing extension process was confirmed to match households’ economic recovery. A post-disaster housing implementation framework for the indigenous population is proposed. [Research limitations/implications] This research only targeted one indigenous community with a limited number of interviewees and samples because of the connection with households. [Practical implications] The study’s proposed resilience post-disaster housing framework can be used to develop post-disaster housing design guidelines, which can benefit policymaking. The proposed participatory concept can be further adopted in future disaster risk-reduction programs. [Originality/value] This study uniquely focuses on the pre- and post-disaster housing layout and the livelihood of an indigenous community. It offers valuable insights for post-disaster reconstruction planners and practitioners
Terrestrial water storage anomalies emphasize interannual variations in global mean sea level during 1997-1998 and 2015-2016 El Nino Events
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Kuo, Y.-N., Lo, M.-H., Liang, Y.-C., Tseng, Y.-H., & Hsu, C.-W. Terrestrial water storage anomalies emphasize interannual variations in global mean sea level during 1997-1998 and 2015-2016 El Nino Events. Geophysical Research Letters, 48(18), (2021): e2021GL094104, https://doi.org/10.1029/2021GL094104.Interannual variations in global mean sea level (GMSL) closely correlate with the evolution of El Niño-Southern Oscillation. However, GMSL differences occur in extreme El Niños; for example, in the 2015–2016 and 1997–1998 El Niños, the peak GMSL during the mature stage of the former (9.00 mm) is almost 2.5 times higher than the latter (3.72 mm). Analyses from satellite and reanalysis data sets show that the disparity in GMSL is primarily due to barystatic (ocean mass) changes. We find that the 2015–2016 event developed not purely as an Eastern Pacific El Niño event but with Central Pacific (CP) El Niño forcing. CP El Niños contribute to a stronger negative anomaly of global terrestrial water storage and subsequent higher barystatic heights. Our results suggest that the mechanism of hydrology-related interannual variations of GMSL should be further emphasized, as more CP El Niño events are projected to occur.This study was supported by a grant of MOST 106-2111-M-002-010-MY4 to National Taiwan University
The Design and Implementation of the Defender Cloud on TWAREN Backbone
Defender Cloud is a cloud based backbone network defending system having full scope over the whole backbone network. Rather than detecting suspicious network activities on a local area network, it collects and integrates the flow data from all connecting members and all entrances of a backbone network. After analyzing by a proposed cloud based distributed processing model, the corresponding defensive reaction can be carried out in a global basis. Thus its protection can cover the whole network, even including member institutions without their own firewall. This paper illustrates the design, verification and future perspective of the Defender Cloud, with an emphasis on the distributed processing of the flow data
Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice
Panax notoginseng (PN) is a traditional Chinese herb experimentally proven to have anti-inflammatory effects, and it is used clinically for the treatment of atherosclerosis, cerebral infarction, and cerebral ischemia. This study aimed to determine the anti-inflammatory effects of PN against bleomycin-induced pulmonary fibrosis in mice. First, in an in vitro study, culture media containing lipopolysaccharide (LPS) was used to stimulate macrophage cells (RAW 264.7 cell line). TNF-α and IL-6 levels were then determined before and after treatment with PN extract. In an animal model (C57BL/6 mice), a single dose of PN (0.5 mg/kg) was administered orally on Day 2 or Day 7 postbleomycin treatment. The results showed that TNF-α and IL-6 levels increased in the culture media of LPS-stimulated macrophage cells, and this effect was significantly inhibited in a concentration-dependent manner by PN extract. Histopathologic examination revealed that PN administered on Day 7 postbleomycin treatment significantly decreased inflammatory cell infiltrates, fibrosis scores, and TNF-α, TGF-β, IL-1β, and IL-6 levels in bronchoalveolar lavage fluid when compared with PN given on Day 2 postbleomycin treatment. These results suggest that PN administered in the early fibrotic stage can attenuate pulmonary fibrosis in an animal model of idiopathic pulmonary fibrosis
Rainfall Variation under Different Climate Change Scenarios Based on Cmip3 and Cmip5 Projections: a Case Study in Taiwan
Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive
Predicting customer lifetime value for hypermarket private label products
This study develops a model to predict customer lifetime value for hypermarket private label products. It examines the relationships among store awareness, store image variables (i.e., service quality, price/value, convenience, and product quality), private label image, repurchase intention, and customer lifetime value and investigates the moderating role of image fit. The originality of this study lies in filling the gap of previous research on antecedents of private label customers’ behavior by considering store awareness, image fit, and customer lifetime value. Partial least squares structural equation modeling was used to analyze data. The results indicate the following. Store image variables (except product quality) and store awareness affect repurchase intention directly or indirectly through private label image. Image fit moderates the relationships between store image variables (except product quality) and private label image. Private label image facilitates customer lifetime value. This study provides several theoretical and practical implications for hypermarket private label product developments
Exponential ATP amplification through simultaneous regeneration from AMP and pyrophosphate for luminescence detection of bacteria
a b s t r a c t Bacteria monitoring is essential for many industrial manufacturing processes, particularly those involving in food, biopharmaceuticals, and semiconductor production. Firefly luciferase ATP luminescence assay is a rapid and simple bacteria detection method. However, the detection limit of this assay for Escherichia coli is approximately 10 4 colony-forming units (CFU), which is insufficient for many applications. This study aims to improve the assay sensitivity by simultaneous conversion of PP i and AMP, two products of the luciferase reaction, back to ATP to form two chain-reaction loops. Because each consumed ATP continuously produces two new ATP molecules, this approach can achieve exponential amplification of ATP. Two consecutive enzyme reactions were employed to regenerate AMP into ATP: adenylate kinase converting AMP into ADP using UTP as the energy source, and acetate kinase catalyzing acetyl phosphate and ADP into ATP. The PP i -recycling loop was completed using ATP sulfurylase and adenosine 5 0 phosphosulfate. The modification maintains good quantification linearity in the ATP luminescence assay and greatly increases its bacteria detection sensitivity. This improved method can detect bacteria concentrations of fewer than 10 CFU. This exponential ATP amplification assay will benefit bacteria monitoring in public health and manufacturing processes that require high-quality water. Ó 2011 Elsevier Inc. All rights reserved. Bacteria monitoring is essential for many industrial manufacturing processes, and particularly those involving food, semiconductors, and biopharmaceuticals. The presence of bacteria reduces production yield and may cause serious health problems in humans. Researchers have developed several rapid assays for detecting bacteria in water. These methods include polymerase chain reactions, fluorescence in situ hybridization [1], b-D-glucuronidase activity measurement The ATP luminescence assay is a rapid, sensitive, and easy-toperform method based on the detection of ATP, a molecule ubiquitously present in all living cells. The enzyme luciferase catalyzes the oxidation of the substrate luciferin while transforming the energy derived from ATP into light, which can be quantified by a luminometer. This assay has been widely used in bacteria monitoring for food hygiene [4] and surface cleanliness The current detection limit of the ATP luminescence method for Escherichia coli is approximately 10 4 colony-forming units (CFU) 1 [12,13], which is not sensitive enough for many industrial and medical applications. Several approaches have been adopted to improve the assay sensitivity. The first strategy involves the identification of chemical extractants that can effectively disrupt bacterial cells while not interfering with the luminescence assay. Both dimethyl sulfoxide (DMSO) 0003-2697/$ -see front matter
Pretreatment carcinoembryonic antigen level is a risk factor for para-aortic lymph node recurrence in addition to squamous cell carcinoma antigen following definitive concurrent chemoradiotherapy for squamous cell carcinoma of the uterine cervix
<p>Abstract</p> <p>Background</p> <p>To identify pretreatment carcinoembryonic antigen (CEA) levels as a risk factor for para-aortic lymph node (PALN) recurrence following concurrent chemoradiotherapy (CCRT) for cervical cancer.</p> <p>Methods</p> <p>From March 1995 to January 2008, 188 patients with squamous cell carcinoma (SCC) of the uterine cervix were analyzed retrospectively. No patient received PALN irradiation as the initial treatment. CEA and squamous cell carcinoma antigen (SCC-Ag) were measured before and after radiotherapy. PALN recurrence was detected by computer tomography (CT) scans. We analyzed the actuarial rates of PALN recurrence by using Kaplan-Meier curves. Multivariate analyses were carried out with Cox regression models. We stratified the risk groups based on the hazard ratios (HR).</p> <p>Results</p> <p>Both pretreatment CEA levels ≥ 10 ng/mL and SCC-Ag levels < 10 ng/mL (<it>p </it>< 0.001, HR = 8.838), SCC-Ag levels ≥ 40 ng/mL (<it>p </it>< 0.001, HR = 12.551), and SCC-Ag levels of 10-40 ng/mL (<it>p </it>< 0.001, HR = 4.2464) were significant factors for PALN recurrence. The corresponding 5-year PALN recurrence rates were 51.5%, 84.8%, and 27.5%, respectively. The 5-year PALN recurrence rate for patients with both low (< 10 ng/mL) SCC and CEA was only 9.6%. CEA levels ≥ 10 ng/mL or SCC-Ag levels ≥ 10 ng/mL at PALN recurrence were associated with overall survival after an isolated PALN recurrence. Pretreatment CEA levels ≥ 10 ng/mL were also associated with survival after an isolated PALN recurrence.</p> <p>Conclusions</p> <p>Pretreatment CEA ≥ 10 ng/mL is an additional risk factor of PALN relapse following definitive CCRT for SCC of the uterine cervix in patients with pretreatment SCC-Ag levels < 10 ng/mL. More comprehensive examinations before CCRT and intensive follow-up schedules are suggested for early detection and salvage in patients with SCC-Ag or CEA levels ≥ 10 ng/mL.</p
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