Effect of continuous positive airway pressure therapy on a large hemangioma complicated with obstructive sleep apnea syndrome: a case report

<p>Abstract</p> <p>Introduction</p> <p>Hemangiomas involving the upper airway can be an uncommon cause of obstructive sleep apnea syndrome.</p> <p>Case presentation</p> <p>A 26-year-old Caucasian man with a known history of a large hemangioma of his head and neck presented with sleep-disordered breathing to the sleep unit of our hospital. Severe obstructive sleep apnea syndrome was revealed on polysomnography. Nasal continuous positive airway pressure was implemented effectively, reducing daytime hypersomnolence and significantly improving sleep parameters. After three years of adherent use, the patient remains in a good condition and the hemangioma is stable.</p> <p>Conclusion</p> <p>Application of continuous positive airway pressure can be an effective treatment for patients with obstructive sleep apnea syndrome complicated with vascular tumors. Periodic follow-up of these patients is necessary, as little is known about the long-term effects of continuous positive airway pressure therapy.</p

Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas

<p>Abstract</p> <p>Background</p> <p>Mammographic density (MD) and malignant-appearing microcalcifications (MAMCs) represent the earliest mammographic findings of non-palpable breast carcinomas. Matrix proteoglycans versican and decorin are frequently over-expressed in various malignancies and are differently involved in the progression of cancer. In the present study, we have evaluated the expression of versican and decorin in non-palpable breast carcinomas and their association with high risk mammographic findings and tumor characteristics.</p> <p>Methods</p> <p>Three hundred and ten patients with non-palpable suspicious breast lesions, detected during screening mammography, were studied. Histological examination was carried out and the expression of decorin, versican, estrogen receptor α (ERα), progesterone receptor (PR) and c-erbB2 (HER-2/neu) was assessed by immunohistochemistry.</p> <p>Results</p> <p>Histological examination showed 83 out of 310 (26.8%) carcinomas of various subtypes. Immunohistochemistry was carried out in 62/83 carcinomas. Decorin was accumulated in breast tissues with MD and MAMCs independently of the presence of malignancy. In contrast, versican was significantly increased only in carcinomas with MAMCs (median ± SE: 42.0 ± 9.1) and MD (22.5 ± 10.1) as compared to normal breast tissue with MAMCs (14.0 ± 5.8), MD (11.0 ± 4.4) and normal breast tissue without mammographic findings (10.0 ± 2.0). Elevated levels of versican were correlated with higher tumor grade and invasiveness in carcinomas with MD and MAMCs, whereas increased amounts of decorin were associated with <it>in situ </it>carcinomas in MAMCs. Stromal deposition of both proteoglycans was related to higher expression of ERα and PR in tumor cells only in MAMCs.</p> <p>Conclusions</p> <p>The specific accumulation of versican in breast tissue with high MD and MAMCs only in the presence of malignant transformation and its association with the aggressiveness of the tumor suggests its possible use as molecular marker in non-palpable breast carcinomas.</p

Parameters affecting water vapor adsorption by the soil under semi-arid climatic conditions

Water vapor adsorption by the soil in Mediterranean ecosystems is very important to plant growth, We hypothesized that relative air humidity, soil texture, soil water content, and soil surface conditions affect water vapor adsorption. These factors were studied in four areas in Greece with semi-arid climatic conditions on four soils classified as Xerochrept. The study was conducted on hilly areas with various physiographic and microclimatic conditions greatly affecting daily fluctuations of air humidity. Time domain reflectometers (TDR) continuously monitored soil water content at depths 5, 10 and 25 cm. Rainfall, open pan water evaporation, air temperature, and relative air humidity were measured every 40 s, averaged. and recorded on data loggers every hour. Two weighing lysimeters were used to confirm soil water data measured by TDR-electrodes.status: publishe

Supply Chain Management, Certificate Management at the Transportation Layer Security in Charge of Security

In the public key infrastructure, the certification authority is fully trusted, and the security of the public key infrastructure depends on the trust of the certification authority; however, recent attacks and corruption on the certification authority indicate that the certificate is forged when the certification authority fails . New solutions, blockchain-based public key infrastructure products and registry can repair vulnerabilities in public key infrastructure, especially weaker security systems. Proposals for infrastructure-based public key infrastructure. Public keys are still the target of global attacks. According to the registration of the target victim, it is signed as a temporary public key infrastructure based on the blockchain. High growth rates require permission to use the wallet. To solve this problem, this document introduces an integrated and responsible system for managing security certificates at the transport layer that represents the next generation of public key infrastructure.I merged two new architectures, introduced a new process, and created a registration and CA server. The domain owner has been notified. In supply chain management, the domain certificate signed by the CA is stored on the registration server, and the certificate server and the CA registration server are forwarded to the group that owns the domain. Compared with existing supply chain public key infrastructure products. The above-mentioned blockchain-based public key infrastructure scheme and registry are used for security and governance analysis