The Chinese New Middle Class and Green NGOs in South China: Vanguards of Guanxi (Connections)-Seeking, Laggards in Promoting Social Causes?

By examining the emerging Chinese new middle class as well as green non-governmental organisations, this study finds that while the emergence of the Chinese new middle class facilitates the growth of green NGOs, the Chinese new class is not activists or agitators working against the government. Based on in-depth interviews with leaders of green NGOs founded by the Chinese new middle class in Guangdong province, this research examines why green NGOs do not call for or advocate environmental protection It concludes that contrary to conventional wisdom, the Chinese new middle class is a vanguard of guanxi (connections)-seeking, but a laggard in promoting environmental protection and civil-society activism. Green NGOs are principally used as a tool to cultivate social capital in the form of guanxi in order to promote personal material interests

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

“Be the Dream Queen”: Gender Performativity, Femininity, and Transgender Sex Workers in China

An under-researched aspect of transgender sex workers in China pertains to their desires and expressions of femininity. Male-to-Female (MTF) transgender sex workers are a high-risk population prone to depression and stress regarding body image, intimate relationships marked by violence, and social stigma, rendering them vulnerable to hate crimes and discrimination. Ethnographic data from in-depth interviews with 49 MTF transgender sex workers indicate that sex, gender and feminine desire are mutable in the construction of self and subjectivity. This study uses the conceptual framework of gender performativity, that is, gender is performative and distinct from physical bodies and binary classifications. It is not only an individual’s normative gender expressions which are based on the sex assigned at birth, but it also reinforces the normative gender performances of the gender binary. This article argues that the 49 MTF transgender sex workers are embodiments of gendered performances, displaying femininity to ameliorate hate crimes and discrimination as well as reinforce the masculinity and sexuality of their clients and intimate sex partners. Embracing their femininity constitutes a self-help program, enabling them to build self-confidence and develop a positive self-image in the face of overwhelming social disapproval

Parental Socialization and Development of Chinese Youths: A Multivariate and Comparative Approach

Parental socialization has been recently reported as a multifaceted concept, which includes parenting practices and family processes. Nevertheless, prior family research generally treated parental socialization tantamount to parenting behavior only and overlooked its different effects on multiple youth outcomes simultaneously, especially in the Chinese population. This study, with a sample of 223 Chinese parent-youth dyads (80.7% mothers; 55.6% male youths; meanage = 16.7 years), found that both authoritative parenting and positive family processes, as measured by a multi-informant approach, significantly predicted higher self-esteem, self-control, future orientation, other perspective taking and lower externalizing problem behavior of Chinese youths concomitantly. Furthermore, youth self-esteem was found to significantly mediate the effects of authoritative parenting and positive family processes on their self-control, future orientation, other perspective taking and externalizing problem behavior, and different facets of parental socialization significantly predicted the youth outcomes differentially. Results of this study highlight importance of considering the multifaceted nature of parental socialization and interrelations of youth development