Ferromagnetic effect and spin assignment for the 390 keV state in 62Cu

The 390 keV isomeric state of 62Cu is assigned as Jπ = 4+. The magnetic hyperfine interaction has been observed in the 60Ni(α, pnγ) 62Cu reaction and the deduced Larmor period is consistent with known values of g and the hyperfine field of Cu in Ni

Vegetative and reproductive growth behaviour of Xanthostemon chrysanthus (F. Muell.) benth. – an ornamental tree in Malaysia

A study was conducted to investigate the duration of growth stages and flowering behaviour of a landscape tree, Xanthostemon chrysanthus (F. Muell.) Benth. This species is known as golden penda and locally known as jambu kuning. It is widely planted for urban beautification due to its distinctive coloured flowers. Under local climate condition, this species flowers throughout the year. However, the flowering of this species has not been studied extensively. In the present study, the growth of selected trees aged approximately six years after planting was monitored for a year. The growth duration was determined using the extended Biologishe Bundesanstalt, Bundessortenamt and Chemical Industry (BBCH) scale. Percentages of flower and fruit and new leaf abundances were expressed as estimated percentage of each stage as compared to total surface area of the tree crown. The vegetative and reproductive stages of the species required 198 and 176 days, respectively. The flowering period took about 40 days from inflorescence bud swelling to drying and senescence of stamens and petals. Unsynchronized flowering was observed among the trees. The occurrence of flowers was also influenced by the development of new leaves or fruits. The information on the duration of each growth stage and the flowering behaviour of the species may enhance a more detailed study related to flowering of urban trees in Malaysia

Cross-Study Projections of Genomic Biomarkers: An Evaluation in Cancer Genomics

Human disease studies using DNA microarrays in both clinical/observational and experimental/controlled studies are having increasing impact on our understanding of the complexity of human diseases. A fundamental concept is the use of gene expression as a “common currency” that links the results of in vitro controlled experiments to in vivo observational human studies. Many studies – in cancer and other diseases – have shown promise in using in vitro cell manipulations to improve understanding of in vivo biology, but experiments often simply fail to reflect the enormous phenotypic variation seen in human diseases. We address this with a framework and methods to dissect, enhance and extend the in vivo utility of in vitro derived gene expression signatures. From an experimentally defined gene expression signature we use statistical factor analysis to generate multiple quantitative factors in human cancer gene expression data. These factors retain their relationship to the original, one-dimensional in vitro signature but better describe the diversity of in vivo biology. In a breast cancer analysis, we show that factors can reflect fundamentally different biological processes linked to molecular and clinical features of human cancers, and that in combination they can improve prediction of clinical outcomes

Bright microwave pulses from PSR B0531+21 observed with a prototype transient survey receiver

Recent discoveries of transient radio events have renewed interest in time-variable astrophysical phenomena. Many radio transient events are rare, requiring long observing times for reliable statistical study. The National Aeronautics and Space Administration/Jet Propulsion Laboratory\u27s Deep Space Network (DSN) tracks spacecraft nearly continuously with 13 large-aperture, low system temperature radio antennas. During normal spacecraft operations, the DSN processes only a small fraction of the pre-detection bandwidth available from these antennas; any information in the remaining bandwidth, e.g., from an astronomical source in the same antenna beam as the spacecraft, is currently ignored. As a firmware modification to the standard DSN tracking receiver, we built a prototype receiver that could be used for astronomical transient surveys. Here, we demonstrate the receiver\u27s utility through observations of bright pulses from the Crab pulsar and describe attributes of potential transient survey observations piggybacking on operational DSN tracks. © 2014. The American Astronomical Society. All rights reserved.

mRNA-Based Anti-TCR CDR3 Tumour Vaccine for T-Cell Lymphoma

Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production of individualised vaccines conferring, T-cell immunity against specific cancer mutations. The CDR3 hypervariable regions of immune receptors (T-cell receptor, TCR or B-cell receptor, BCR) in the context of T- or B-cell leukaemia or lymphoma are targetable and specific sequences, similar to cancer mutations. We evaluated the functionality of an mRNA-based vaccine designed to trigger immunity against TCR CDR3 regions in an EL4 T-lymphoma cell line-derived murine in vivo model. Vaccination against the hypervariable TCR regions proved to be a feasible approach and allowed for protection against T-lymphoma, even though immune escape in terms of TCR downregulation paralleled the therapeutic effect. However, analysis of human cutaneous T-cell lymphoma samples indicated that, as is the case in B-lymphomas, the clonotypic receptor may be a driver mutation and is not downregulated upon treatment. Thus, vaccination against TCR CDR3 regions using customised ivt mRNA is a promising immunotherapy method to be explored for the treatment of patients with T-cell lymphomas

Comparison of bed-up-head-elevated intubation position with Glidescope assisted tracheal intubation: a randomised, controlled, non-inferiority trial

Proper positioning during intubation is critical in order to increase the likelihood of success. The bed-up-headelevated (BUHE) intubation position has been shown to improve laryngeal view, reduce airway complications and prolong safe apneic time during intubation. Concurrently in the last decade, there has been an exponential increase in the use of video laryngoscopy (VL) devices, especially for difficult airway patients, as it has been shown to improve laryngeal exposure. The use of VL will increase, and may replace traditional laryngoscopy one day. In this study, we sought to determine if the BUHE intubation position is non-inferior to Glidescope-assisted intubation with regards to laryngeal exposure. In addition, we aimed to determine the differences in time required for intubation (TRI) in the two groups

The cellular and synaptic architecture of the mechanosensory dorsal horn

The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LTMR-RZ processing in tactile perception, and the basic logic of LTMR-RZ organization. We found an unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiological, and synaptic properties. Remarkably, LTMRs form synapses on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons. Thus, the LTMR-RZ is a somatosensory processing region endowed with a neuronal complexity that rivals the retina and functions to pattern the activity of ascending touch pathways that underlie tactile perception

Comparison of Macintosh Laryngoscopy in Bed-up-Head–Elevated Position With GlideScope Laryngoscopy: A Randomized, Controlled, Noninferiority Trial

BACKGROUND: Approximately half of all difficult tracheal intubations (DTIs) are unanticipated; hence, proper positioning during intubation is critical to increase the likelihood of success. The bed-up-head–elevated (BUHE) intubation position has been shown to improve laryngeal view, reduce airway complications, and prolong safe apneic time during intubation. In this study, we sought to determine whether the BUHE intubation position is noninferior to Glidescope (GLSC)- assisted intubation with regard to laryngeal exposure. METHODS: A total of 138 American Society of Anesthesiologists (ASA) I to III patients were randomly assigned into 2 groups and underwent baseline laryngoscopy in the sniffing position. Group BUHE patients (n = 69) were then intubated in the BUHE position, while group GLSC patients (n = 69) were intubated using GLSC laryngoscopy. Laryngeal exposure was measured using Percentage of Glottic Opening (POGO) score and Cormack–Lehane (CL) grading, and noninferiority will be declared if the difference in mean POGO scores between both groups do not exceed −15% at the lower limit of a 98% confidence interval (CI). Secondary outcomes measured included time required for intubation (TRI), number of intubation attempts, use of airway adjuncts, effort during laryngoscopy, and complications during intubation. RESULTS: Mean POGO score in group BUHE was 80.14% ± 22.03%, while in group GLSC it was 86.45% ± 18.83%, with a mean difference of −6.3% (98% CI, −13.2% to 0.6%). In both groups, there was a significant improvement in mean POGO scores when compared to baseline laryngoscopy in the sniffing position (group BUHE, 25.8% ± 4.7%; group GLSC, 30.7% ± 6.8%) (P < .0001). The mean TRI was 36.23 ± 14.41 seconds in group BUHE, while group GLSC had a mean TRI of 44.33 ± 11.53 seconds (P < .0001). In patients with baseline CL 3 grading, there was no significant difference between mean POGO scores in both groups (group BUHE, 49.2% ± 19.6% versus group GLSC, 70.5% ± 29.7%; P = .054). CONCLUSIONS: In the general population, BUHE intubation position provides a noninferior laryngeal view to GLSC intubation. The laryngeal views obtained in both approaches were superior to the laryngeal view obtained in the sniffing position. In view of the many advantages of the BUHE position for intubation, the lack of proven adverse effects, the simplicity, and the costeffectiveness, we propose that clinicians should consider the BUHE position as the standard intubation position for the general population. (Anesth Analg 2020;131:210–9