1,801 research outputs found
Association Between Timing of Antibiotic Administration and Mortality from Septic Shock in Patients Treated with a Quantitative Resuscitation Protocol
Objective
We sought to determine the association between time to initial antibiotics and mortality of septic shock patients treated with an emergency department (ED) based early resuscitation protocol.
Design
Pre-planned analysis of a multicenter randomized controlled trial of early sepsis resuscitation.
Setting
3 urban US EDs.
Patients
Adult septic shock patients.
Interventions
A quantitative resuscitation protocol in the ED targeting 3 physiological variables: central venous pressure, mean arterial pressure and either central venous oxygen saturation or lactate clearance. The study protocol was continued until all endpoints were achieved or a maximum of 6 hours.
Measurements
Data on patients who received an initial dose of antibiotics after presentation to the ED were categorized based on both time from triage and time from shock recognition to initiation of antibiotics. The primary outcome was in-hospital mortality.
Main Results
Of 291 included patients, mortality did not change with hourly delays in antibiotic administration up to 6 hours after triage: 1 hour (OR 1.2, 0.6–2.5), 2 hours (OR 0.71, 0.4–1.3), 3 hours (OR 0.59, 0.3–1.3). Mortality was significantly increased patients who received initial antibiotics after shock recognition (N=172, 59%) compared with before shock recognition (OR 2.4, 1.1–4.5); however, among patients who received antibiotics after shock recognition, mortality did not change with hourly delays in antibiotic administration.
Conclusion
In this large, prospective study of ED patients with septic shock, we found no increase in mortality with each hour delay to administration of antibiotics after triage. However, delay in antibiotics until after shock recognition was associated with increased mortality
Feasibility Studies for Single Transverse-Spin Asymmetry Measurements at a Fixed-Target Experiment Using the LHC Proton and Lead Beams (AFTER@LHC)
The measurement of Single Transverse-Spin Asymmetries, A_N, for various quarkonium states and Drell–Yan lepton pairs can shed light on the orbital angular momentum of quarks and gluons, a fundamental ingredient of the proton-spin puzzle. The AFTER@LHC proposal combines a unique kinematic coverage and large luminosities thanks to the Large Hadron Collider beams to deliver precise measurements, complementary to the knowledge provided by collider experiments such as at RHIC. In this paper, we report on sensitivity studies for J/ ψ, Υ and Drell–Yan A_N done using the performance of LHCb-like or ALICE-like detectors, combined with polarised gaseous hydrogen and helium-3 targets. In particular, such analyses will provide us with new insights and knowledge about transverse-momentum-dependent parton distribution functions for quarks and gluons and on twist-3 collinear matrix elements in the proton and the neutron
First measurement of production in pp collisions at = 7 TeV
The production of the charm-strange baryon is measured for
the first time at the LHC via its semileptonic decay into e
in pp collisions at TeV with the ALICE detector. The transverse
momentum () differential cross section multiplied by the branching
ratio is presented in the interval 1 8 GeV/ at
mid-rapidity, 0.5. The transverse momentum dependence of the
baryon production relative to the D meson production is
compared to predictions of event generators with various tunes of the
hadronisation mechanism, which are found to underestimate the measured
cross-section ratio.Comment: 22 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/412
Energy dependence of exclusive photoproduction off protons in ultra-peripheral p-Pb collisions at = 5.02 TeV
The ALICE Collaboration has measured the energy dependence of exclusive
photoproduction of vector mesons off proton targets in
ultra-peripheral p-Pb collisions at a centre-of-mass energy per nucleon pair
TeV. The ee and decay channels
are used to measure the cross section as a function of the rapidity of the
in the range , corresponding to an energy in the
p centre-of-mass in the interval GeV.
The measurements, which are consistent with a power law dependence of the
exclusive photoproduction cross section, are compared to previous
results from HERA and the LHC and to several theoretical models. They are found
to be compatible with previous measurements.Comment: 25 pages, 3 captioned figures, 3 tables, authors from page 19,
published version, figures at http://alice-publications.web.cern.ch/node/455
Measurement of the production of charm jets tagged with D mesons in pp collisions at = 7 TeV
The production of charm jets in proton-proton collisions at a center-of-mass
energy of TeV was measured with the ALICE detector at the CERN
Large Hadron Collider. The measurement is based on a data sample corresponding
to a total integrated luminosity of , collected using a
minimum-bias trigger. Charm jets are identified by the presence of a D
meson among their constituents. The D mesons are reconstructed from their
hadronic decay DK. The D-meson tagged jets are
reconstructed using tracks of charged particles (track-based jets) with the
anti- algorithm in the jet transverse momentum range
and pseudorapidity
. The fraction of charged jets containing a D-meson
increases with from to . The distribution of D-meson tagged jets as a
function of the jet momentum fraction carried by the D meson in the
direction of the jet axis () is reported for two ranges
of jet transverse momenta, and
in the intervals
and , respectively. The
data are compared with results from Monte Carlo event generators (PYTHIA 6,
PYTHIA 8 and Herwig 7) and with a Next-to-Leading-Order perturbative Quantum
Chromodynamics calculation, obtained with the POWHEG method and interfaced with
PYTHIA 6 for the generation of the parton shower, fragmentation, hadronisation
and underlying event.Comment: 29 pages, 8 captioned figures, 3 tables, authors from page 24,
published version, figures at http://alice-publications.web.cern.ch/node/525
Constraining the magnitude of the Chiral Magnetic Effect with Event Shape Engineering in Pb-Pb collisions at = 2.76$ TeV
In ultrarelativistic heavy-ion collisions, the event-by-event variation of
the elliptic flow reflects fluctuations in the shape of the initial state
of the system. This allows to select events with the same centrality but
different initial geometry. This selection technique, Event Shape Engineering,
has been used in the analysis of charge-dependent two- and three-particle
correlations in Pb-Pb collisions at TeV. The
two-particle correlator ,
calculated for different combinations of charges and , is
almost independent of (for a given centrality), while the three-particle
correlator
scales almost linearly both with the event and charged-particle
pseudorapidity density. The charge dependence of the three-particle correlator
is often interpreted as evidence for the Chiral Magnetic Effect (CME), a parity
violating effect of the strong interaction. However, its measured dependence on
points to a large non-CME contribution to the correlator. Comparing the
results with Monte Carlo calculations including a magnetic field due to the
spectators, the upper limit of the CME signal contribution to the
three-particle correlator in the 10-50% centrality interval is found to be
26-33% at 95% confidence level.Comment: 20 pages, 6 captioned figures, 1 tables, authors from page 15,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/382
- …