Spectator detection for the measurement of proton neutron interactions at ANKE

A telescope of three silicon detectors has been installed close to the internal target position of the ANKE spectrometer, which is situated inside the ultra-high vacuum of the COSY-Juelich light-ion storage ring. The detection and identification of slow protons and deuterons emerging from a deuterium cluster-jet target thus becomes feasible. A good measurement of the energy and angle of such a spectator proton (p_sp) allows one to identify a reaction as having taken place on the neutron in the target and then to determine the kinematical variables of the ion-neutron system on an event-by-event basis over a range of c.m. energies. The system has been successfully tested under laboratory conditions. By measuring the spectator proton in the p d to p_sp d pi^0 reaction in coincidence with a fast deuteron in the ANKE Forward Detector, values of the p n to d pi^0 total cross-section have been deduced. Further applications of the telescope include the determination of the luminosity and beam polarisation which are required for several experiments.Comment: 16 pages, 9 figure

MRI study of the cuprizone-induced mouse model of multiple sclerosis: demyelination is not found after co-treatment with polyprenols (long-chain isoprenoid alcohols)

Multiple sclerosis is a neurological disorder with poorly understood pathogenic mechanisms and a lack of effective therapies. Therefore, the search for new MS treatments remains very important. This study was performed on a commonly used cuprizone animal model of multiple sclerosis. It evaluated the effect of a plant-derived substance called Ropren® (containing approximately 95% polyprenols or long-chain isoprenoid alcohols) on cuprizone- induced demyelination. The study was performed on 27 eight-week old male CD-1 mice. To induce demyelination mice were fed 0.5% cuprizone in the standard diet for 10 weeks. Ropren® was administered in one daily intraperitoneal injection (12mg/kg), beginning on the 6th week of the experiment. On the 11th week, the corpus callosum in the brain was evaluated in all animals using magnetic resonance imaging with an 11.7 T animal scanner using T2- weighted sequence. Cuprizone treatment successfully induced the model of demyelination with a significant decrease in the size of the corpus callosum compared with the control group (p<0.01). Mice treated with both cuprizone and Ropren® did not exhibit demyelination in the corpus callosum (p<0.01). This shows the positive effect of polyprenols on cuprizone-induced demyelination in mice

Nucleon matrix elements and baryon masses in the Dirac orbital model

Using the expansion of the baryon wave function in a series of products of single quark bispinors (Dirac orbitals), the nonsinglet axial and tensor charges of a nucleon are calculated. The leading term yields $g_A = 1.27$ in good agreement with experiment. Calculation is essentially parameter-free and depends only on the strong coupling constant value $\alpha_s$. The importance of lower Dirac bispinor component, yielding 18% to the wave function normalization is stressed. As a check, the baryon decuplet masses in the formalism of this model are also computed using standard values of the string tension $\sigma$ and the strange quark mass $m_s$; the results being in a good agreement with experiment.Comment: 8 pages, 2 tables; LaTeX2

Metabolism effector links in diet-induced and genetically-based obesity: A full-transcriptome study of liver tissue in experimental models in rodents

Background. When developing methods for personalized diet therapy of obesity, an urgent task is to study the molecular genetics features of the obesity pathogenesis using in vivo experimental models in laboratory animals.The aim. To determine metabolism effector links in obesity based on a comparative analysis of full-transcriptome profiles of the liver tissue of mice and rats of various strains.Materials and methods. We carried out a comparative analysis of the changes in liver transcriptome in rats and mice fed with diets of excessive energy value and exerting lipogenic effect. Data of full-transcriptome profiling using DNA microarray technology have been presented previously in 8 publications. Results. In three strains of mice treated with a high-carbohydrate high-fat diet (HCHFD), a significant differential expression (DE) of 1849 genes was revealed, of which 74 genes responded jointly in at least two groups of animals. In Wistar and Zuckerfa rats, 2109 genes responded to the consumption of HCHFD, of which 242 genes responded jointly in two groups of animals. For rodents different in genetic predisposition to the development of diet-induced obesity, the groups of genes that responded with the opposite sign of DE (depending on the genotype) in reaction to the consumption of HCHFD were identified. Bioinformatical analysis allowed establishing the presence of 43 metabolic pathways, which are targeted for the applied experimental diets exposure, in rats and 77 pathways – in mice. Four of these pathways – the pathway of retinoid metabolism, PPAR signaling pathway associated with it the previous one, xenobiotics metabolism and drugs metabolism mediated by cytochrome P450 system – responded in all groups of animals (except for female mice). The importance of the expression of Tat gene encoding tyrosine aminotransferase in the modulation of biogenic amines synthesis in diet-induced obesity was shown, which may represent a new neurometabolic regulatory function of the liver in response to the consumption of high-calorie diets. Conclusion. The analysis of the results of full-transcriptome studies showed that within each studied species (Rattus rattus and Mus domesticus) and animal sex, a number of genetic variants with a greater or lesser predisposition to the development of diet-induced obesity phenotype can be identified; and at the same time, within these variants, there is a largely similar pattern in the response of metabolism effector links to hypercaloric dietary intake. This pattern creates new prospects for translating the results of transcriptomic and metabolomic studies of laboratory animals into clinical practice in order to substantiate new approaches to personalized diet therapy of alimentary dependent diseases in patients with different genetic predisposition to obesity

Resonance-like coherent production of a pion pair in the reaction pd→pdππpd \rightarrow pd\pi\pi in the GeV region

The reaction $p + d \rightarrow p + d + X$ was studied at 0.8-2.0 GeV proton beam energies with the ANKE magnetic spectrometer at the COSY synchrotron storage ring. The proton-deuteron pairs emerging with high momenta, 0.6-1.8 GeV/$c$, were detected at small angles with respect to the proton beam. Distribution over the reaction missing mass $M_x$ reveals a local enhancement near the threshold of the pion pair production specific for the so-called ABC effect. The enhancement has a structure of a narrow bump placed above a smooth continuum. The invariant mass of the $d\pi\pi$ system in this enhancement region exhibits a resonance-like peak at $M_{d\pi\pi} \approx 2.36$ GeV/$c^2$ with the width $\Gamma \approx 0.10$ GeV/$c^2$. A possible interpretation of these features is discussed.Comment: 14 pages, 16 figures, submitted to Eur. Phys. J. A. v2: Added references [42,43] in section IV.A. v3: revised version according to referee remarks v4: revised version according to referee remark

The energy dependence of the pp->K+ n Sigma+ reaction close to threshold

The production of the Sigma+ hyperon through the pp->K+nSigma+ reaction has been investigated at four energies close to threshold, 1.826, 1.920, 1.958, and 2.020 GeV. At low energies, correlated K+pi+ pairs can only originate from Sigma+ production so that their measurement allows the total cross section for the reaction to be determined. The results obtained are completely consistent with the values extracted from the study of the K+-proton correlation spectra obtained in the same experiment. These spectra, as well as the inclusive K+ momentum distributions, also provide conservative upper limits on the Sigma+ production rates. The measurements show a Sigma+ production cross section that varies roughly like phase space and, in particular, none of the three experimental approaches used supports the anomalously high near-threshold pp->K+ nSigma+ total cross section previously reported [T. Rozek et al., Phys. Lett. B 643, 251 (2006)].Comment: Submitted to PR

Kaon pair production in proton-nucleus collisions at 2.83 GeV kinetic energy

The production of non-phi K+K- pairs by protons of 2.83 GeV kinetic energy on C, Cu, Ag, and Au targets has been investigated using the COSY-ANKE magnetic spectrometer. The K- momentum dependence of the differential cross section has been measured at small angles over the 0.2--0.9 GeV/c range. The comparison of the data with detailed model calculations indicates an attractive K- -nucleus potential of about -60 MeV at normal nuclear matter density at a mean momentum of 0.5 GeV/c. However, this approach has difficulty in reproducing the smallness of the observed cross sections at low K- momenta.Comment: 7 pages, 5 figures, 1 tabl

First measurements of spin correlations in the np -> d pi^0 reaction

The transverse spin correlations Axx and Ayy in the np-> d pi^0 reaction have been measured for the first time in quasi-free kinematics at the COSY-ANKE facility using a polarised deuteron beam incident on a polarised hydrogen cell target. The results obtained for neutron energies close to 353 MeV and 600 MeV are in good agreement with the partial wave analysis of data on the isospin-related pp-> d pi^+ reaction, though the present results cover also the small-angle region, which was largely absent from these data