Bone cross-sectional geometry in male runners, gymnasts, swimmers and non-athletic controls: a hip-structural analysis study.

Loading of the skeleton is important for the development of a functionally and mechanically appropriate bone structure, and can be achieved through impact exercise. Proximal femur cross-sectional geometry was assessed in the male athletes (n = 55) representing gymnastics, endurance running and swimming, and non-athletic controls (n = 22). Dual energy X-ray absorptiometry (iDXA, GE Healthcare, UK) measurements of the total body (for body composition) and the left proximal femur were obtained. Advanced hip structural analysis (AHA) was utilised to determine the areal bone mineral density (aBMD), hip axis length (HAL), cross-sectional area (CSA), cross-sectional moment of inertia (CSMI) and the femoral strength index (FSI). Gymnasts and runners had greater age, height and weight adjusted aBMD than in swimmers and controls (p < 0.05). Gymnasts and runners had greater resistance to axial loads (CSA) and the runners had increased resistance against bending forces (CSMI) compared to swimmers and controls (p < 0.01). Controls had a lower FSI compared to gymnasts and runners (1.4 vs. 1.8 and 2.1, respectively, p < 0.005). Lean mass correlated with aBMD, CSA and FSI (r = 0.365-0.457, p < 0.01), particularly in controls (r = 0.657-0.759, p < 0.005). Skeletal loading through the gymnastics and running appears to confer a superior bone geometrical advantage in the young adult men. The importance of lean body mass appears to be of particular significance for non-athletes. Further characterisation of the bone structural advantages associated with different sports would be of value to inform the strategies directed at maximising bone strength and thus, preventing fracture

The Longitudinal Stability of Flying Boats as Determined by Tests of Models in the NACA Tank II : Effect of Variations in Form of Hull on Longitudinal Stability

Data taken from tests at constant speed to establish trim limits of stability, tests at accelerated speeds to determine stable limits of center of gravity shift, and tests at decelerated speeds to obtain landing characteristics of several model hull forms were used to establish hull design effect on longitudinal stability of porpoising. Results show a reduction of dead rise angle as being the only investigated factor reducing low trim limit. Various methods of reducing afterbody interference increased upper trim limi

How effective is school-based deworming for the community-wide control of soil-transmitted helminths?

Background: The London Declaration on neglected tropical diseases was based in part on a new World Health Organization roadmap to “sustain, expand and extend drug access programmes to ensure the necessary supply of drugs and other interventions to help control by 2020”. Large drug donations from the pharmaceutical industry form the backbone to this aim, especially for soil-transmitted helminths (STHs) raising the question of how best to use these resources. Deworming for STHs is often targeted at school children because they are at greatest risk of morbidity and because it is remarkably cost-effective. However, the impact of school-based deworming on transmission in the wider community remains unclear. Methods: We first estimate the proportion of parasites targeted by school-based deworming using demography, school enrolment, and data from a small number of example settings where age-specific intensity of infection (either worms or eggs) has been measured for all ages. We also use transmission models to investigate the potential impact of this coverage on transmission for different mixing scenarios. Principal Findings: In the example settings <30% of the population are 5 to <15 years old. Combining this demography with the infection age-intensity profile we estimate that in one setting school children output as little as 15% of hookworm eggs, whereas in another setting they harbour up to 50% of Ascaris lumbricoides worms (the highest proportion of parasites for our examples). In addition, it is estimated that from 40–70% of these children are enrolled at school. Conclusions: These estimates suggest that, whilst school-based programmes have many important benefits, the proportion of infective stages targeted by school-based deworming may be limited, particularly where hookworm predominates. We discuss the consequences for transmission for a range of scenarios, including when infective stages deposited by children are more likely to contribute to transmission than those from adults

Anomalous dispersion and negative-mass dynamics of exciton polaritons in an atomically thin semiconductor

Dispersion engineering is a powerful and versatile tool that can vary the speed of light signals and induce negative-mass effects in the dynamics of electrons, quasiparticles, and quantum fluids. Here, we demonstrate that dissipative coupling between bound electron-hole pairs (excitons) and photons in an optical microcavity can lead to the formation of exciton polaritons with an inverted dispersion of the lower polariton branch and hence, a negative mass. We perform a direct measurement of the anomalous dispersion in an atomically thin WS$_2$ crystal embedded in a planar microcavity, and demonstrate that the propagation direction of the negative-mass polaritons is opposite to their momentum. Our study introduces a new concept of non-Hermitian dispersion engineering for exciton polaritons and shows a pathway for realising new phases of quantum matter in a solid state.Comment: 7 pages, 4 figure

Bright matter wave solitons in Bose-Einstein condensates

We review recent experimental and theoretical work on the creation of bright matter wave solitons in Bose–Einstein condensates. In two recent experiments, solitons are formed from Bose–Einstein condensates of 7Li by utilizing a Feshbach resonance to switch from repulsive to attractive interactions. The solitons are made to propagate in a one-dimensional potential formed by a focused laser beam. For repulsive interactions, the wavepacket undergoes dispersivewavepacket spreading, while for attractive interactions, localized solitons are formed. In our experiment, a multi-soliton train containing up to ten solitons is observed to propagate without spreading for a duration of 2 s. Adjacent solitons are found to interact repulsively, in agreement with a calculation based on the nonlinear Schr¨odinger equation assuming that the soliton train is formed with an alternating phase structure. The origin of this phase structure is not entirely clear

Can chemotherapy alone eliminate the transmission of soil transmitted helminths?

Background Amongst the world’s poorest populations, availability of anthelmintic treatments for the control of soil transmitted helminths (STH) by mass or targeted chemotherapy has increased dramatically in recent years. However, the design of community based treatment programmes to achieve the greatest impact on transmission is still open to debate. Questions include: who should be treated, how often should they be treated, how long should treatment be continued for? Methods Simulation and analysis of a dynamic transmission model and novel data analyses suggest refinements of the World Health Organization guidelines for the community based treatment of STH. Results This analysis shows that treatment levels and frequency must be much higher, and the breadth of coverage across age classes broader than is typically the current practice, if transmission is to be interrupted by mass chemotherapy alone. Conclusions When planning interventions to reduce transmission, rather than purely to reduce morbidity, current school-based interventions are unlikely to be enough to achieve the desired results