Spectrum of practice in the routine management of cervical dystonia with abobotulinumtoxinA: findings from three prospective open-label observational studies.

Background: Cervical dystonia is a heterogeneous disorder with several possible presentations, for which first-line therapy is often botulinum toxin (BoNT). In routine clinical practice the success of each BoNT injection is dependent on several variables, including individual presentation and injection technique. Large multicenter, observational studies provide important information on individualized administration strategies that cannot be otherwise ascertained from controlled clinical trials. In this meta-analysis of patient level data, we aimed to evaluate the clinical characteristics of patients with cervical dystonia undergoing routine treatment with botulinum toxin, specifically abobotulinumtoxinA. We also aimed to characterize current abobotulinumtoxinA injection techniques and parameters and to explore international differences in patient presentation and treatment. Methods: This was a meta-analysis of baseline data from three prospective, international, multicenter, observational studies (NCT01314365, NCT00833196 and NCT01753349) of botulinum toxin treatment for the routine management of adult cervical dystonia. Results: Data presented illustrate the significant heterogeneity of CD presentation in routine practice. Most subjects presented with a complex pattern of dystonic movements and the majority had additional components of shoulder elevation, tremor and/or jerk. Dosing was generally in accordance with that recommended in the abobotulinumtoxinA prescribing information, although the range of dosing also indicates that injections are tailored to individual presentation. Sub-group analyses at the country level revealed distinct differences in injection practice. Conclusions: This meta-analysis is based on the largest dataset of subjects with cervical dystonia studied to date. The heterogeneity revealed in our baseline findings support the need to develop consistent, practical and comprehensive best practice guidelines

Bringing Racial Justice to the Courtroom and Community: Race Matters for Juvenile Justice and the Charlotte Model

This article describes regional institutional organizing efforts to bring racial justice to the Charlotte courts and community through a collaborative called Race Matters for Juvenile Justice (RMJJ). The authors explain community and institutional organizing in-depth using the example of minority overrepresentation in the juvenile justice system, but recognize the pervasiveness of racial and ethnic disparities. Moreover, as the Race Matters for Juvenile Justice-Charlotte Model has gained national prominence, many jurisdictions seek to replicate the collaborative and the authors, therefore, provide RMJJ’s history as well as strategies for changing the narrative through communication and education, workforce development, data and research, community collaboration, practice change, and legislation reform

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Dans le premier numéro de la revue Pyramides, publié au printemps 2000, M. William Dumazy et moi-même évoquions la nouvelle compétence confiée par le législateur à la Cour des comptes en matière de bon usage des deniers publics. Deux premiers rapports d'audit, portant sur des matières fédérales, ont depuis lors été transmis à la Chambre des représentants. Ils concernent le recouvrement des créances non fiscales et des amendes pénales par les services des Domaines (ministère des Finances) et l..

Reconstructing a Classical Kithara

From the Washington University Senior Honors Thesis Abstracts (WUSHTA), Spring 2015. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Stacy Ross, Editor; Kristin G. Sobotka, Undergraduate Research Coordinator; Jennifer Kohl. Mentor: Timothy Moor

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Cet ouvrage de poche, bon marché, constitue une excellente introduction aux questions politiques actuelles en matière de fiscalité. Au départ de la situation française, l'auteur assortit son livre de nombreuses comparaisons internationales et d'analyses pertinentes. Celles-ci montrent que les débats politiques menés dans ce domaine en Belgique trouvent un écho dans les autres pays industrialisés. Tel est le cas, par exemple, de la pression fiscale, de la part relative des prélèvements fiscaux..

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La dette des pouvoirs publics belges constitue depuis une trentaine d'années un élément permanent qui pèse lourdement sur la gestion politique. L'existence de cette dette imposante a justifié l'adoption de multiples décisions impopulaires et a expliqué les refus ou les reports, sans doute encore plus nombreux, de réformes jugées nécessaires ou utiles, par exemple en matière de recherche scientifique, d'enseignement et d'administration de la justice. On a même pu, dans certains cas, présenter ..