9 research outputs found
Updated therapeutic outcome for patients with periampullary and pancreatic cancer related to recent translational research
Prognostic Impact of Resection Margin Status in Distal Pancreatectomy for Ductal Adenocarcinoma
Abstract
Background
Resection margin status is considered one of the few surgeon-controlled parameters affecting prognosis in pancreatic ductal adenocarcinoma (PDAC). While studies mostly focus on resection margins in pancreatoduodenectomy, little is known about their role in distal pancreatectomy (DP). This study aimed to investigate resection margins in DP for PDAC.
Methods
Patients who underwent DP for PDAC between October 2004 and February 2020 were included ( n  = 124). Resection margins and associated parameters were studied in two consecutive time periods during which different pathology examination protocols were used: non-standardized (period 1: 2004–2014) and standardized (period 2: 2015–2020). Microscopic margin involvement ( R 1) was defined as ≤1 mm clearance.
Results
Laparoscopic and open resections were performed in 117 (94.4%) and 7 (5.6%) patients, respectively. The R 1 rate for the entire cohort was 73.4%, increasing from 60.4% in period 1 to 83.1% in period 2 ( p  = 0.005). A significantly higher R 1 rate was observed for the posterior margin (35.8 vs. 70.4%, p  < 0.001) and anterior pancreatic surface (based on a 0 mm clearance; 18.9 vs. 35.4%, p  = 0.045). Pathology examination period, poorly differentiated PDAC, and vascular invasion were associated with R 1 in the multivariable model. Extended DP, positive anterior pancreatic surface, lymph node ratio, perineural invasion, and adjuvant chemotherapy, but not R 1, were significant prognostic factors for overall survival in the entire cohort.
Conclusions
Pathology examination is a key determinant of resection margin status following DP for PDAC. A high R 1 rate is to be expected when pathology examination is meticulous and standardized. Involvement of the anterior pancreatic surface affects prognosis
Trends in management and outcome of cystic pancreatic lesions – analysis of 322 cases undergoing surgical resection
Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma – A population-based cohort study
Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: results of a multicenter cohort study on 196 patients
BackgroundLaparoscopy is widely accepted as a feasible option for distal pancreatectomy. However, the experience in laparoscopic distal pancreatectomy (LDP) for pancreatic ductal adenocarcinoma (PDAC) is limited to a small number of studies, reported by expert centers. The present study aimed to evaluate perioperative and oncological outcomes after LDP for PDAC in a large, multicenter cohort of patients.MethodsA retrospective analysis of the data on 196 patients with histologically verified PDAC, operated at Oslo University Hospital—Rikshospitalet (Oslo, Norway), Asan Medical Center (Seoul, Republic of Korea), Institut Mutualiste Montsouris (Paris, France) and University Hospital Southampton (Southampton, UK) between January 2002 and April 2015 was conducted. The patients with standard (SLDP) and extended (i.e., en bloc with adjacent organ, ELDP) resections were compared in terms of perioperative and oncological outcomes.ResultsOut of 196 LDP procedures, 191 (97.4 %) were completed through laparoscopy, while five (2.6 %) were converted to open surgery. ELDP was performed in 30 (15.7 %) cases. Sixty-one (31.9 %) patients experienced postoperative complications, including 48 (25.1 %) with pancreatic fistula. The rate of clinically relevant fistula (grade B/C) was 15.7 %. Median postoperative hospital stay was 8 (2–63) days. Median follow-up was 16 months. Median survival was 31.3 months (95 % CI 22.9–39.6). Three- and 5-year actuarial survival rates were 42.4 and 30 %, respectively. SLDP was associated with significantly higher survival compared with ELDP (p = 0.032).ConclusionsLDP seems to be a feasible and safe procedure, providing satisfactory oncological outcomes in patients with PDAC