EFFECTS of SELECTIVE ADRENOCEPTOR AGONISTS and ANTAGONISTS ON AGGRESSIVE-BEHAVIOR ELICITED BY APOMORPHINE, DL-DOPA and FUSARIC ACID in REM-SLEEP-DEPRIVED RATS

REM sleep deprivation (REMSD) results in behavioral changes such as the appearance of affective aggression induced by apomorphine (APO) and other dopaminergic agents. REMSD modifies dopamine-mediated behavior as well as the adrenergic receptor sensitivity. This paper evaluates the interaction between these two neurotransmission systems through changes in APO-, DL-DOPA- and fusaric acid (FA)-induced aggressive behavior in REMSD rats pretreated with phentolamine, propranolol, metaraminol, prazosin, clonidine, yohimbine, isoproterenol, butoxamine and maprotiline. Only isoproterenol reduced FA-induced aggressiveness. No specific changes in aggressiveness were noticed with other treatments and not even inhibitors of norepinephrine transmission induced aggressive behavior. It is concluded that norepinephrine had a slight inhibitory action on aggressiveness elicited by dopaminomimetic agents in REMSD rats. Beta-adrenoceptors could be responsible for this effect since only beta-selective drugs reduced aggression. As REMSD reduces beta-adrenoceptor sensitivity, only minor changes in aggressiveness could be observed. It was noted that the three drugs used to induce aggressive behavior elicited different patterns of aggression.ESCOLA PAULISTA MED SCH,DEPT PSICOBIOL,BR-04023 São Paulo,BRAZILESCOLA PAULISTA MED SCH,DEPT PSICOBIOL,BR-04023 São Paulo,BRAZILWeb of Scienc

EFFECTS of SELECTIVE ADRENOCEPTOR AGONISTS and ANTAGONISTS ON AGGRESSIVE-BEHAVIOR ELICITED BY APOMORPHINE, DL-DOPA and FUSARIC ACID in REM-SLEEP-DEPRIVED RATS

REM sleep deprivation (REMSD) results in behavioral changes such as the appearance of affective aggression induced by apomorphine (APO) and other dopaminergic agents. REMSD modifies dopamine-mediated behavior as well as the adrenergic receptor sensitivity. This paper evaluates the interaction between these two neurotransmission systems through changes in APO-, DL-DOPA- and fusaric acid (FA)-induced aggressive behavior in REMSD rats pretreated with phentolamine, propranolol, metaraminol, prazosin, clonidine, yohimbine, isoproterenol, butoxamine and maprotiline. Only isoproterenol reduced FA-induced aggressiveness. No specific changes in aggressiveness were noticed with other treatments and not even inhibitors of norepinephrine transmission induced aggressive behavior. It is concluded that norepinephrine had a slight inhibitory action on aggressiveness elicited by dopaminomimetic agents in REMSD rats. Beta-adrenoceptors could be responsible for this effect since only beta-selective drugs reduced aggression. As REMSD reduces beta-adrenoceptor sensitivity, only minor changes in aggressiveness could be observed. It was noted that the three drugs used to induce aggressive behavior elicited different patterns of aggression.ESCOLA PAULISTA MED SCH,DEPT PSICOBIOL,BR-04023 São Paulo,BRAZILESCOLA PAULISTA MED SCH,DEPT PSICOBIOL,BR-04023 São Paulo,BRAZILWeb of Scienc

REVERSAL of the INCREASE in APOMORPHINE-INDUCED STEREOTYPY and AGGRESSION in REM-SLEEP DEPRIVED RATS BY DOPAMINE AGONIST PRETREATMENTS

ESCOLA PAULISTA MED,DEPT PSICOBIOL,RUA BOTUCATU 862,BR-04023 São Paulo,SP,BRAZILESCOLA PAULISTA MED,DEPT PSICOBIOL,RUA BOTUCATU 862,BR-04023 São Paulo,SP,BRAZILESCOLA PAULISTA MED,DEPT PSICOBIOL,RUA BOTUCATU 862,BR-04023 São Paulo,SP,BRAZILWeb of Scienc

EFFECTS of CHRONIC HALOPERIDOL ON STRESS-INDUCED ORAL BEHAVIOR in RATS

ESCOLA PAULISTA MED, DEPT PSYCHOBIOL, BR-04023 São Paulo, SP, BRAZILESCOLA PAULISTA MED, DEPT PSYCHOBIOL, BR-04023 São Paulo, SP, BRAZILWeb of Scienc

DOES REM-SLEEP DEPRIVATION INDUCE SUBSENSITIVITY of PRESYNAPTIC DOPAMINE OR POSTSYNAPTIC ACETYLCHOLINE-RECEPTORS in the RAT-BRAIN

ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,BR-04023 São Paulo,SP,BRAZILESCOLA PAULISTA MED,DEPT PSYCHOBIOL,BR-04023 São Paulo,SP,BRAZILWeb of Scienc

EFFECTS of STRESS ON DRUG-INDUCED YAWNING - CONSTANT VS INTERMITTENT STRESS

Experiment 1 tested whether chronic exposure to immobilization, foot shock or forced swimming would result in suppression of apomorphine, pilocarpine-, and physostigmine-induced yawning. Immobilization caused suppression of yawning, whereas foot shock and swimming resulted in increased number of yawns. Since interstressor interval was long in the two latter stressors, animals could have recovered and the increase in yawning could be due to the last (acute) exposure to stress. in Experiment 2 we recorded the number of yawns induced by pilocarpine in animals exposed to 1 h of swimming or foot shock. No differences between control and acutely stressed animals were detected. These results suggest that yawning is differently altered by constant and intermittent stressors (i.e., diminished by constant and increased by intermittent stress).ESCOLA PAULISTA MED,DEPT PSYCHOBIOL,RUA BOTUCATU 862,1 ANDAR,BR-04023062 São Paulo,BRAZILESCOLA PAULISTA MED,DEPT PSYCHOBIOL,RUA BOTUCATU 862,1 ANDAR,BR-04023062 São Paulo,BRAZILWeb of Scienc

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.<br>O sono ocupa cerca de um terço de nossas vidas, entretanto seu impacto na saúde e sua influência nas condições patológicas ainda não foi completamente elucidado. A prevalência dos distúrbios de sono é cada vez maior, sobretudo nas regiões mais industrializadas, repercutindo diretamente no bem-estar da população. Este artigo tem como objetivo sintetizar e atualizar a literatura a respeito do método de privação de sono paradoxal e seu panorama de conseqüências desde comportamentais até genéticas em animais. Ainda, destacamos a contribuição e relevância dos estudos experimentais realizados por nosso grupo nas ultimas três décadas