Fabrication and Evaluation of Physically Crosslinked Stimuli Sensitive Polymeric Blend of Pva-Gelatin as Drug Delivery System by Freeze Thaw Cycles: Crosslinked Stimuli Sensitive Polymeric Blend by Freeze Thaw Cycles

Vacuum dried Metronidazole hydrochloride (MTZ) loaded Crosslinked polymeric blend of Poly (vinyl) alcohol (PVA) and Gelatin (GE) in different ratios by 30 freeze/thaw cycles (FTC) tested for stimuli sensitivity and crosslinking at various pH, temperature, ionic concentration and oscillatory test along with dye absorption test showed maximum swelling in alkaline pH and decreased swelling with increased ionic concentration. Digital scanning calorimetry (DSC) thermo grams of the blank crosslinked sample showed a sharp endothermic peak at 160.57 0C and MTZ loaded samples showed two sharp endothermic peaks at 159.95 0C and 324.74 0C indicating the entrapment of drug in the polymeric network. Scanning electron microscopy (SEM) showed the rough polymeric texture. Fourier Transformation Infrared Spectroscopy (FTIR) confirmed the presence of new peaks in the cross-linked and drug-loaded sample. In-vitro drug release studies showed 98.253% ± 0.363 and 92.248% ± 0.244 releases in the first 6 hours. Biodegradability and bactericidal studies of the blank film indicated that the crosslinked sample is biodegradable and does not inhibit any microbial growth

A COMPARATIVE STUDY ON EFFECTIVENESS OF OPEN VERSUS CLOSED KINETIC CHAIN EXERCISES TO IMPROVE GAIT IN SPASTIC DIPLEGIC CEREBRAL PALSY

Background: Cerebral Palsy (CP) describes a non- progressive but not unchanging disorder of movement and posture due to an insult to or anomaly of the developing brain. People with spastic diplegia typically walk slowly and have difficulties in performing activities such as walking running or jumping. Children with spastic diplegic cerebral palsy are relied more on cadence to increase speed. Hence, the purpose of this study is to compare the effectiveness of open and closed kinetic chain (OKC and CKC) exercises in improving gait in spastic diplegic cerebral palsy. Methods: 30 children with spastic diplegic cerebral palsy of both genders with age 4-12 years was taken. Cadence and distance covered in 1Minute Walk Test was calculated before and after the test. The intervention for group A was CKC exercises and group B was OKC exercises for 3 days a week for 6 weeks and each session lasted for 30-45 minutes was given for both the groups. Results: Paired t-test was performed to find effectiveness of CKC and OKC improving gait in spastic diplegic CP to see the difference of means of 1minute walk, t = 10.789 which is significant (p = 0.000) and for cadence, t = 3.37 which is highly significant (p = 0.00) implying that cadence and distance covered in1minute walk was more with CKC exercises. Conclusion: Based on the result it is concluded that CKC exercises are effective in improving gait than OKC exercises in spastic diplegic cerebral palsy