21 research outputs found
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Draft Genome Sequences of Two Vibrio parahaemolyticus Strains Associated with Gastroenteritis after Raw Seafood Ingestion in Colorado.
Vibrio parahaemolyticus is a Gram-negative pathogen associated with gastrointestinal and wound infections after exposure to raw seafood or contaminated waters. We report here the whole-genome sequences of two stool isolates (CDC-AM50933 and CDC-AM43539) from patients in Colorado presenting with gastroenteritis after ingesting raw seafood
Introduction: Toward an Engaged Feminist Heritage Praxis
We advocate a feminist approach to archaeological heritage work in order to transform heritage practice and the production of archaeological knowledge. We use an engaged feminist standpoint and situate intersubjectivity and intersectionality as critical components of this practice. An engaged feminist approach to heritage work allows the discipline to consider womenâs, menâs, and gender non-conforming personsâ positions in the field, to reveal their contributions, to develop critical pedagogical approaches, and to rethink forms of representation. Throughout, we emphasize the intellectual labor of women of color, queer and gender non-conforming persons, and early white feminists in archaeology
Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)
The Global Parkinsonâs Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia
Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease
Although over 90 independent risk variants have been identified for Parkinsonâs disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinsonâs disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations
Recommended from our members
Draft Genome Sequences of Two Vibrio parahaemolyticus Strains Associated with Gastroenteritis after Raw Seafood Ingestion in Colorado.
Vibrio parahaemolyticus is a Gram-negative pathogen associated with gastrointestinal and wound infections after exposure to raw seafood or contaminated waters. We report here the whole-genome sequences of two stool isolates (CDC-AM50933 and CDC-AM43539) from patients in Colorado presenting with gastroenteritis after ingesting raw seafood
Symmetry-Breaking Charge Transfer in a Zinc Chlorodipyrrin Acceptor for High Open Circuit Voltage Organic Photovoltaics
Low
open-circuit voltages significantly limit the power conversion
efficiency of organic photovoltaic devices. Typical strategies to
enhance the open-circuit voltage involve tuning the HOMO and LUMO
positions of the donor (D) and acceptor (A), respectively, to increase
the interfacial energy gap or to tailor the donor or acceptor structure
at the D/A interface. Here, we present an alternative approach to
improve the open-circuit voltage through the use of a zinc chlorodipyrrin,
ZCl [bisÂ(dodecachloro-5-mesityldipyrrinato)Âzinc], as an acceptor,
which undergoes symmetry-breaking charge transfer (CT) at the donor/acceptor
interface. DBP/ZCl cells exhibit open-circuit voltages of 1.33 V compared
to 0.88 V for analogous tetraphenyldibenzoperyflanthrene (DBP)/C<sub>60</sub>-based devices. Charge transfer state energies measured by
Fourier-transform photocurrent spectroscopy and electroluminescence
show that C<sub>60</sub> forms a CT state of 1.45 ± 0.05 eV in
a DBP/C<sub>60</sub>-based organic photovoltaic device, while ZCl
as acceptor gives a CT state energy of 1.70 ± 0.05 eV in the
corresponding device structure. In the ZCl device this results in
an energetic loss between <i>E</i><sub>CT</sub> and <i>qV</i><sub>OC</sub> of 0.37 eV, substantially less than the
0.6 eV typically observed for organic systems and equal to the recombination
losses seen in high-efficiency Si and GaAs devices. The substantial
increase in open-circuit voltage and reduction in recombination losses
for devices utilizing ZCl demonstrate the great promise of symmetry-breaking
charge transfer in organic photovoltaic devices
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection