Staging Diplomacy in Eighteenth-Century Rome: The Festival of the Chinea

Guide to exhibit held by Watkinson Library. Prints from the Vincent J. Buonanno Collection January 24 - February 28, 200

Should a Non-Designing Manufacturer Be Held Strictly Liable for a Design Defect? An Approach for California

This Comment recommends how the California Supreme Court should handle a situation in which a manufacturer conforms to the buyer’s design in building a product, and then the product causes injury to a person because of a design defect. The California Supreme Court has not addressed whether the manufacturer in such situation should be held strictly liable. The approaches in two other jurisdictions are analyzed to illustrate how well each approximates the goals behind tort liability. The “Nebraska Rule” finds a non-designing manufacturer liable for a design defect only upon proof of that the manufacturer was at fault for following the buyer’s design. Conversely, the “New Jersey Rule” holds a non-designing manufacturer strictly liable for a design defect regardless of fault. The Author recommends that the California Supreme Court adopt the rationale of the Nebraska Rule because it is more compatible with California’s current strict liability standards

Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds

During colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that influence cellular dynamics in the colonic epithelium can also directly affect their epigenetic landscape. We hypothesize that the chemoprotective nutritional bioactives found in fish oil and fermentable fiber can act as epigenetic modifiers and mechanistically counteract epigenetic distortions associated with colonic tumorigenesis. Fermentable fiber generates short-chain fatty acids (SCFA), e.g., butyrate, in the lumen of the colon that can serve as a chemoprotective histone deacetylase inhibitor and/or as an acetylation substrate for histone acetylases. In addition, n-3 polyunsaturated fatty acids (n-3 PUFAs) in fish oil can affect the chromatin landscape by acting as ligands for tumor suppressive nuclear receptors. In an effort to gain insight into the extensive dimension of post-translational modifications in histones (including H3K4me3 and H3K9ac) and elucidate the chemoprotective impact of dietary bioactive compounds on transcriptional control in a colon cancer preclinical model, we generated high-resolution genome-wide RNA (RNA-Seq) and “chromatin-state” (H3K4me3-seq and H3K9ac-seq) maps for intestinal (epithelial colonocytes) crypts in rats treated with a colon carcinogen and fed bioactive (i) fish oil (ii) butyrate (in the form of a fermentable fiber a rich source of SCFA), (iii) a combination of fish oil plus butyrate or (iv) control diets. Poor correlation was observed between differentially transcribed (DE) and enriched genes (DERs) at multiple epigenetic levels in fat x fiber dietary combinations and in the presence/absence of carcinogen. The genome-wide carcinogen (AOM) effects were most prevalent at the RNA (116 DE genes) and K4me3 (7678 DERs including 3792 genes) levels. Pathway analysis of the differentially transcribed genes after AOM exposure indicated a strong link to interferon-associated innate immune responses often associated with anti-microbial activity, while K4me3 DERs were strongly linked to colon tumorigenesis. However, these changes in K4me3 enrichment were not reflected at the transcriptional level during the early stages of cancer progression. Therefore, we propose that carcinogen-induced changes in genes with K4me3 DERs are harbingers of future transcriptional events, which drive malignant transformation of the colon cells. We also demonstrated that the combinatorial diet (fish oil + pectin) was synergistically chemoprotective, and uniquely affected epigenetic profiles in the intestinal epithelium, e.g., upregulating lipid catabolism and beta-oxidation associated genes. These genes were linked to activated ligand-dependent nuclear receptors associated with n-3 PUFAs and were also correlated with the inhibition of lipogenesis and a decreased concentration of cholesterol. Interestingly, only a subset of these genes was affected in animals fed fish oil without pectin, and there was a markedly enhanced effect of biological mechanisms associated with n-3 PUFAs in the combinatorial diet. In conclusion, we propose that the chemoprotective effects of the bioactive mediators of the combination fish oil + pectin diet during colon cancer progression are multifaceted and generate specific epigenetic modifications and transcriptional profiles. Our data contribute to the understanding of the regulatory action of chemoprotective bioactive compounds found in fish oil and readily fermentable fiber (n-3 PUFAs and SCFAs) in colonic crypts and provide mechanistic insight into current clinical and epidemiological findings

Automatic inventory identification through image recognition

110 leaves : illustrations (some colour) ; 29 cmIncludes abstract and appendices.Includes bibliographical references (leaves 99-103).Companies are looking to use technology to replace repetitive, low skill tasks currently performed by human employees. One such series of tasks is conducting an inventory of items within a warehouse. This requires employees to identify individual items on a shelf. This task is well-suited to the application of computer vision techniques. Images of shelves in a warehouse can be acquired and analyzed. The goal of this research is to accurately identify items within the images for the purpose of inventory management. This objective requires both the detection of objects within an image, and the identification of those objects. I propose a series of techniques to identify an item against a set of template images of potential items. To demonstrate the effectiveness of these techniques, I have developed a prototype system that performs an inventory of equipment in a data centre

Designing an Intensive Bespoke Course in Cross-Cultural Communication

AbstractPurpose of study. In order to be successful in a multicultural society, business professionals need to develop a strong understanding of the reality of both their home and the foreign business environment. Sources of Evidence. The current paper will focus on the challenges and outcomes of designing an intensive bespoke course in cross-cultural communication (CC) for pre-service MA students in Tourism, Restaurants and Hospitality.Findings and Results. Designing a CC intensive module for future specialists likely to work in a multicultural team can represent a real challenge from the point of view of defining its objectives i.e. prioritizing content on the one hand, and of selecting the methods, strategies and style of delivery on the other so as to ensure relevance, usefulness, interactivity and accessibility. We further point out that modules of cross-cultural communication can be successful in ‘in vitro’ learning environments provided that they are made more real, meaningful and memorable by lifting activities off the printed page and by exploiting digital technologies that allow 7 days/24hours access to knowledge.Conclusion. In preparing future professionals to work in a global commercial environment, knowledge of the impact of cultural differences is one of the keys to international business success. Although intensive modules of intercultural communication can represent a real challenge when it comes to defining their objectives i.e. prioritizing content on the one hand, and selecting the methods, strategies and style of delivery on the other, they can be successful provided that activities are lifted off the printed page and are made more accessible, real, meaningful and memorable

Профессиональная заболеваемость в Румынии. Оповещение случаев профессиональных болезней и практическая значимость электронного досье здоровья

Spitalul Judeţean de Urgenţă Dr. Constantin Opriş, Baia Mare, ASTA MM SERV SRL, Viseul de Sus, România, Conferinţa știinţifico-practică naţională cu participare internaţională Sănătatea ocupaţională: probleme și realizări prima ediţie 5-7 iunie 2014Based on existing law in occupational medicine in Romania, the article presents the main elements of the informational circuit in declaring of occupational diseases Romania. The main reasons for the decline in occupational morbidity, proposing measures for better supervision of health workers, optimizing information flow in occupational illness declaration and increasing quality standards in occupational medicine are presented. The centerpiece is the electronic health record implementation in occupational medicine.Учитывая действующее законодательство в области медицины труда а Румынии, в двнной статье представлены ключевые элементы цепи оповещения профессиональных заболеваний в Румынии. Представлены основные причины снижения уровня профессионаальной заболеваемости. Предложены меры по улучшению надзора за состоянием здоровья работающих, по оптимизации информационного патока оповещения случаев профессиональных болезней и по повышению стандартов качества в медицине труда

Magyar Tanítóképző 9 (1894) 03-04

Magyar Tanítóképző A Tanítóképző-intézeti Tanárok Országos Egyesületének közlönye 9. évfolyam, 03-04. füzet Budapest, 1894. márczius-április h

Magyar Tanítóképző 8 (1893) 09

Magyar Tanítóképző A Tanítóképző-intézeti Tanárok Országos Egyesületének közlönye 8. évfolyam, 9. füzet Budapest, 1893. november h

Magyar Tanítóképző 9 (1894) 06

Magyar Tanítóképző A Tanítóképző-intézeti Tanárok Országos Egyesületének közlönye 9. évfolyam, 06. füzet Budapest, 1894. június h