315 research outputs found
Purification of Artemisinin from the Product Solution of a Semisynthetic Reaction within a Single Crystallization Step
Pushmepullyou: An efficient micro-swimmer
The swimming of a pair of spherical bladders that change their volumes and
mutual distance is efficient at low Reynolds numbers and is superior to other
models of artificial swimmers. The change of shape resembles the wriggling
motion known as {\it metaboly} of certain protozoa.Comment: Minor rephrasing and changes in style; short explanations adde
Faith in Humanity : An Exploration of Spiritually Inclusive Architecture
On March 15th, 2019 at 1:40 pm, Brenton Harrison Tarrant walked into Al Noor Mosque in New Zealand. Attached to his head, an iPhone set to livestream, and in his hand a loaded shotgun. Brenton then proceeded to gleefully murder 42 innocent Muslim worshippers. Soon after he fled to Linwood Mosque where he claimed 8 more victims. His actions demark New Zealand’s largest terrorist act in history. Brenton joins the long list of individuals who’s gross misunderstanding and hatred of a religion have escalated into violence. People like Brenton represent a larger issue that afflicts our modern society; the widespread vilification, hostility, and abandonment of organized religion and spirituality. This social condition and has bred stereotypes, and misconceptions about faith. Spirituality should be a value that unites people, not divides them. But what truly is Spirituality and Faith? It is a human’s attempt to reconcile with the big questions. Who am I? Why am I here? What does it all mean? It is a trait that defines our humanity. Spirituality is a thread that all humans can access. The controversy is found in the details and differences, that we cling onto. Our gods may not have the same face, but does that mean we can’t share in a spiritual experience? One that transcends the symbolism and specificity, allowing for a mutual appreciation of personal existence. This thesis will focus on developing a form of architecture that allows for a religious and spiritual mitigation space, in which all forms of faith can co-habitat, worship, and appreciate the practices of each other’s spirituality. I wanted to tackle the issue by placing the project site, in a place of high religious tension, the Old Walled City of Jerusalem. Jerusalem has become the physical manifestation of the problem at hand, literally being segregated into Jewish, Muslim, and Christian sections. In addition, the Israel / Palestine conflict, which has lasted over 100 years, takes forefront in the holy city. The project is placed strategically in a small neutral zone between the Israel and Palestine border, making the statement that this is a neutral and inclusive space. This inclusivity will be achieved by identifying and studying the archetypes and motifs that run through all forms of spiritual space. Shared narrative, phenomenology, tectonics, and ritual culminating into an experience that evokes a connectedness to the other, regardless of how you define your spirituality. The project will house spaces that address ubiquitous human experiences; life, death, reflection; which are derived from in depth comparative religious studies. These moments will be arranged into a promenade that take the human on a spiritual journey from secular to sacred; disconnected to enlightened. Resulting in a built form that sheds religious identity while embodying common human experience and struggles in this mortal world. The intention of this thesis is to positively affect the way people think about religion and faith in our modern society
Dynamic webdesign : styleguide for a progressive web presence
Die vorliegende Bachelorarbeit analysiert Anforderungen und Technologien, die es ermöglichen eine dynamische Website plattformübergreifend zu erstellen. Der Untersuchungsmethode des Surfverhaltens von Usern liegt einer Online-Befragung zugrunde. Die Ergebnisse werden vergleichend mit der Studie von Shaikh und Lenz aus dem Jahr 2005 ausgewertet. Resultierend aus Grundlagen, Ergebnissen, Literatur und technischen Möglichkeiten werden Richtlinien zur Erstellung einer dynamischen Website, welche sich jeder Bildschirmgröße stufenlos anpassen soll, hergeleitet
Dynamic webdesign : styleguide for a progressive web presence
Die vorliegende Bachelorarbeit analysiert Anforderungen und Technologien, die es ermöglichen eine dynamische Website plattformübergreifend zu erstellen. Der Untersuchungsmethode des Surfverhaltens von Usern liegt einer Online-Befragung zugrunde. Die Ergebnisse werden vergleichend mit der Studie von Shaikh und Lenz aus dem Jahr 2005 ausgewertet. Resultierend aus Grundlagen, Ergebnissen, Literatur und technischen Möglichkeiten werden Richtlinien zur Erstellung einer dynamischen Website, welche sich jeder Bildschirmgröße stufenlos anpassen soll, hergeleitet
Identifying a kinetic model for the acid-catalyzed sequence of the artemisinin partial synthesis
Parameter Identifiability of Artemisinin Synthesis using Design of Experiments
Artemisinin-based combination therapies are recommended by the World Health Organization to treat malaria, one of
the most abundant infectious diseases in the world. Recently, a novel production route, which combines the extraction
and the catalyzed chemical synthesis, has been shown to be a promising sustainable processing alternative [Triemer,
2018]. To exploit its mechanism, operational settings and limits, mathematical modeling might be beneficial when
thorough system insight is required. In a first step, we consider the catalyzed synthesis step from dihydroartemisinic
acid to artemisinin, and we show that only a subset of the parameters of the considered model is identifiable with the
available sparse data using a singular value decomposition approach. In a second step, within the framework of design
of experiments (DoE), we demonstrate the effect of additional experimental data to overcome the non-identifiability
problem of the model parameters
Kinetic analysis of the partial synthesis of artemisinin: Photooxygenation to the intermediate hydroperoxide
Exposure factors manual
ABSTRACT: Assessing health risks associated with potential exposure to chemicals from petroleum or petrochemical operations requires the consideration of multiple exposure pathways. These pathways include ingestion of water, food, or soil, inhalation of vapors or airborne particulate, and dermal absorption from contaminated soil, water, or by direct skin contact. To estimate the exposures for each pathway, a number of variables related to exposure, that is, exposure factors, are needed. Some categories of exposure factors include physiologic factors (e.g., body weight), time-activity factors (e.g., time spent at home), and contact rate factors (e.g., soil ingestion rate). This manual is organized by exposure factor category and includes a description of selected exposure factors commonly used in risk assessments, a brief summary, and an evaluation of the current scientific data supporting a recommended point value for each factor, and available information on the known distributions. It is hoped that this information will promote consistency and quality among various risk assessment activities
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