86 research outputs found

    Prospectus, July 11, 1984

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    DREAM OF A LIFETIME REALIZED EISNER CHANGES HANDS: BECOMES DIANA FOODS; 98 percent of area residents are within 4 blocks of MTD\u27s economical-efficient-comfortable and friendly transportation; News Digest; Husbands, wives benefit from sharing the work; Did You Know...; Lake of the Woods features \u27Music in Park\u27; Philosophy club proposed; The unsung heros of Parkland; The Garden Spot; Entire student body not at risk; Recycling Center at fair; Annual 4th of July parade provides delights for all; Creative Corner...especially for you; Angie; Rites of Passage; Scared Love; Rejoice the Poet; Odyssey; Stallone\u27s versatility is obvious in Rhinestone performance Dolly and Sly are dynamite; Dr. Who and Star Trek convention; Grace Jones a riot in film debut; Krantz creates magic; Study shows coaches consign blacks to certain positions; ERES mid-stae tour planned; Sports Digest; \u27Everyone has a dream\u27; Tad Powers works on hishttps://spark.parkland.edu/prospectus_1984/1017/thumbnail.jp

    Carbon fiber masculinity: Disability and surfaces of homosociality

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    In this paper I am concerned with instances in which carbon fiber extends performances of masculinity that are attached to particular kinds of hegemonic male bodies. In examining carbon fiber as a prosthetic form of masculinity, I advance three main arguments. Firstly, carbon fiber can be a site of the supersession of disability that is affected through masculinized technology. Disability can be ‘overcome’ through carbon fiber. Disability is often culturally coded as feminine (Pedersen, 2001; Meeuf, 2009; Garland-Thompson 1997). Building on this cultural construction of disability as feminine, in and as a technology of masculine homosociality (Sedgwick, 1985), carbon fiber reproduced disability as feminine when carbon fiber prosthetic lower legs allowed Oscar Pistorius to compete in the non-disabled Olympic games. Secondly, I argue that carbon fiber can be a homosocial surface; that is, carbon fiber becomes both a surface extension of the self and a third party mediator in homosocial relationships, a surface that facilitates intimacy between men in ways that devalue femininity in both male and female bodies. I examine surfaces as material extensions of subjectivity, and carbon fiber surfaces as vectors of the cultural economies of masculine competition to which I refer. Thirdly, the case of Oscar Pistorius is exemplary of the masculinization of carbon fire, and the associated binding of a psychic attitude of misogyny and power to a form of violent and competitive masculine subjectivity. In this article I explore the affects, economies and surfaces of what I call ‘carbon fiber masculinity’ and discusses Pistorius’ use of carbon fiber, homosociality and misogyny as forms of protest masculinity through which he unconsciously attempted to recuperate his gendered identity from emasculating discourses of disability

    Prospectus, April 18, 1984

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    CHORAL UNION DEMANDING AND REWARDING; News Digest; Is your child part of the identi-child program?; Budding playwrights get chance to have work produced; PC Happenings: Parkland wins Automotive Contest, German Club annual Springfest, EMT workshop offered, Petitions available for Stu-Go, Stu-Go lacks quorum; Here Comes the Easter Bunny (or the Easter Hare?); Faces We Make; Former Prospectus entertainment writer: Alender services held; Strange things at the library; Only Food Service Management course in area: Sutton leads Food Service Management program; Criminal justice program well rounded; Running may increase protein need; Easter means Easter egg time; Second Wind hosts race; Did You Know...; Classifieds; Creative Corner...Especially for you!!: Recollections, She\u27s More than a Nurse, You are a corn-fed steak..., Memories..., A fire burns, AKTING??????????????..., Sometimes in their heed to tact..., Clouds, Disturb Not the Dead, Follow the Wind, I don\u27t know why I bother..., Innoncent Eyes, Please tell me what it is you want..., Running scared from yourself and tripped, babe..., Time Bomb, Don\u27t go away--Linger on..., Class, Raggedy Ann lay in the back of an old station wagon..., Too Late, To God; Ice Capades comes to town: Skaters say it\u27s hard work but well worth it; few surprises during Hollywood\u27s biggest night; \u27Queen\u27 film at Assembly Hall; Director shines in film; \u27Go-Go\u27s\u27 are back on track; \u27Weird Al\u27 hits big time; Fan Club to host film; Parkland College 1984 baseball roster; Cobra men lose two; 1984 Parkland Outdoor Track Bests; Sports Digest; Women lose twin bill; Prospectus survey resultshttps://spark.parkland.edu/prospectus_1984/1024/thumbnail.jp

    Molecular Characterization of Spontaneous Mesenchymal Stem Cell Transformation

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    Background. We previously reported the in vitro spontaneous transformation of human mesenchymal stem cells (MSC) generating a population with tumorigenic potential, that we termed transformed mesenchymal cells (TMC). Methodology/Principal Findings. Here we have characterized the molecular changes associated with TMC generation. Using microarrays techniques we identified a set of altered pathways and a greater number of downregulated than upregulated genes during MSC transformation, in part due to the expression of many untranslated RNAs in MSC. Microarray results were validated by qRT-PCR and protein detection. Conclusions/Significance. In our model, the transformation process takes place through two sequential steps; first MSC bypass senescence by upregulating c-myc and repressing p16 levels. The cells then bypass cell crisis with acquisition of telomerase activity, Ink4a/Arf locus deletion and Rb hyperphosphorylation. Other transformation-associated changes include modulation of mitochondrial metabolism, DNA damage-repair proteins and cell cycle regulators. In this work we have characterized the molecular mechanisms implicated in TMC generation and we propose a two-stage model by which a human MSC becomes a tumor cell

    The interactions of disability and impairment

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    Theoretical work on disability is going through an expansive period, built on the growing recognition of disability studies as a discipline and out of the political and analytical push to bring disability into a prominent position within accounts of the intersecting social categories that shape people's lives. A current debate within critical disability studies is whether that study should include impairment and embodiment within its focus. This article argues it should and does so by drawing from symbolic interactionism and embodiment literatures in order to explore how differences in what bodies can do-defined as impairments-come to play a role in how people make sense of themselves through social interaction. We argue that these everyday interactions and the stories we tell within them and about them are important spaces and narratives through which impairment and disability are produced. Interactions and stories are significant both in how they are shaped by wider social norms, collective stories and institutional processes, and also how they at times can provide points of resistance and challenges to such norms, stories and institutions. Therefore, the significance of impairment and interaction is the role they play in both informing self-identity and also broader dynamics of power and inequality

    Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells

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    Hepatocellular carcinoma (HCC) usually arises from hepatic fibrosis caused by chronic inflammation. In chronic liver damage, hepatic stellate cells undergo progressive activation to myofibroblasts (MFB), which are important extracellular-matrix-producing mesenchymal cells. Concomitantly, perturbation of transforming growth factor (TGF)-β signaling by pro-inflammatory cytokines in the epithelial cells of the liver (hepatocytes) promotes both fibrogenesis and carcinogenesis (fibro-carcinogenesis). Insights into fibro-carcinogenic effects on chronically damaged hepatocytes have come from recent detailed analyses of the TGF-β signaling process. Smad proteins, which convey signals from TGF-β receptors to the nucleus, have intermediate linker regions between conserved Mad homology (MH) 1 and MH2 domains. TGF-β type I receptor and pro-inflammatory cytokine-activated kinases differentially phosphorylate Smad2 and Smad3 to create phosphoisoforms phosphorylated at the COOH-terminal, linker, or both (L/C) regions. After acute liver injury, TGF-β-mediated pSmad3C signaling terminates hepatocytic proliferation induced by the pro-inflammatory cytokine-mediated mitogenic pSmad3L pathway; TGF-β and pro-inflammatory cytokines synergistically enhance collagen synthesis by activated hepatic stellate cells via pSmad2L/C and pSmad3L/C pathways. During chronic liver disease progression, pre-neoplastic hepatocytes persistently affected by TGF-β together with pro-inflammatory cytokines come to exhibit the same carcinogenic (mitogenic) pSmad3L and fibrogenic pSmad2L/C signaling as do MFB, thereby accelerating liver fibrosis while increasing risk of HCC. This review of Smad phosphoisoform-mediated signals examines similarities and differences between epithelial and mesenchymal cells in acute and chronic liver injuries and considers Smad linker phosphorylation as a potential target for the chemoprevention of fibro-carcinogenesis
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