26 research outputs found
ΠΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΆΠΈ ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠ΅. Π§Π°ΡΡΡ 1: ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ, ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡ, ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·
Skin and mucous membranes lesions in systemic lupus erythematosus (SLE) significantly impair the quality of life of patients, although they are not a formidable manifestation of the disease. Skin manifestations of SLE can occur both at the onset and on the late stage of the disease. Although skin and mucous membranes lesions are clearly grouped in the latest classification criteria for SLE, verification of the diagnosis requires a multidisciplinary approach. In the etiology of SLE, environmental factors, hormonal factors, and genetic predisposition play a role. Further research will reveal differences in subtypes of cutaneous lupus erythematosus and will facilitate the development of new therapies.ΠΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΆΠΈ ΠΈ ΡΠ»ΠΈΠ·ΠΈΡΡΡΡ
ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΠΊ ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠ΅ (Π‘ΠΠ), Ρ
ΠΎΡΡ ΠΈ Π½Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ Π³ΡΠΎΠ·Π½ΡΠΌ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠΌ, Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΡ
ΡΠ΄ΡΠ°Π΅Ρ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΠΎΠΆΠ½ΡΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ Π‘ΠΠ ΠΌΠΎΠ³ΡΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡ ΠΊΠ°ΠΊ Π² Π΄Π΅Π±ΡΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, ΡΠ°ΠΊ ΠΈ Π² Π±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠ·Π΄Π½Π΅ΠΌ ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅. Π₯ΠΎΡΡ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΡΠΈΡΠ΅ΡΠΈΡΡ
Π‘ΠΠ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΠΆΠΈ ΠΈ ΡΠ»ΠΈΠ·ΠΈΡΡΡΡ
ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΠΊ ΡΠ΅ΡΠΊΠΎ ΡΠ³ΡΡΠΏΠΏΠΈΡΠΎΠ²Π°Π½Ρ, Π²Π΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΡΡΠ΅Π±ΡΠ΅Ρ ΠΌΠ½ΠΎΠ³ΠΎΠΏΡΠΎΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°. Π ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Π‘ΠΠ ΠΈΠ³ΡΠ°ΡΡ ΡΠΎΠ»Ρ ΡΠ°ΠΊΡΠΎΡΡ Π²Π½Π΅ΡΠ½Π΅ΠΉ ΡΡΠ΅Π΄Ρ, Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ Π½Π°ΡΡΡΠ΅Π½Π½ΠΈΡ, Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΡ. ΠΠ°Π»ΡΠ½Π΅ΠΉΡΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΡΡ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² ΠΏΠΎΠ΄ΡΠΈΠΏΠ°Ρ
ΠΊΠΎΠΆΠ½ΠΎΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠΈ ΠΈ Π±ΡΠ΄ΡΡ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ Π½ΠΎΠ²ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ
ΠΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΆΠΈ ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠ΅. Π§Π°ΡΡΡ 2: ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ
Skin lesions in systemic lupus erythematosus (SLE) are not just a cosmetic defect, accompanied by a deterioration in the quality of life and psychological discomfort, but, possibly, the first sign of a systemic course of disease. Systemic involvement can develop in patients with almost any type of cutaneous lupus erythematosus (CLE), requiring the study of CLE in combination with SLE. Dermatologists are the first to face with skin manifestations of SLE, while other organs and systems affection leads the patient to a rheumatologist. It is important to understand that skin lesions do not cause irreversible organ damage, but continuity of therapeutic approaches between a dermatologist and a rheumatologist is necessary. The review presents the clinical signs, diagnostic features and histological characteristics of CLE.ΠΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΆΠΈ ΠΏΡΠΈ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΊΡΠ°ΡΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠ΅ (Π‘ΠΠ) β Π½Π΅ ΠΏΡΠΎΡΡΠΎ ΠΊΠΎΡΠΌΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π΄Π΅ΡΠ΅ΠΊΡ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠΈΠΉΡΡ ΡΡ
ΡΠ΄ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΆΠΈΠ·Π½ΠΈ ΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π΄ΠΈΡΠΊΠΎΠΌΡΠΎΡΡΠΎΠΌ, Π°, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΠΏΠ΅ΡΠ²ΡΠΉ ΠΏΡΠΈΠ·Π½Π°ΠΊ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΏΡΠΈ Π΄Π°Π½Π½ΠΎΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΈ. Π‘ΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΌΠΎΠΆΠ΅Ρ ΡΠ°Π·Π²ΠΈΡΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Ρ Π»ΡΠ±ΡΠΌ ΡΠΈΠΏΠΎΠΌ ΠΊΡΠ°ΡΠ½ΠΎΠΉ ΠΊΠΎΠΆΠ½ΠΎΠΉ Π²ΠΎΠ»ΡΠ°Π½ΠΊΠΈ (ΠΠΠ), ΡΡΠΎ ΡΡΠ΅Π±ΡΠ΅Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΠΠ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π‘ΠΠ. Π ΠΏΠ΅ΡΠ²ΡΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ Ρ ΠΊΠΎΠΆΠ½ΡΠΌΠΈ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ Π‘ΠΠ Π²ΡΡΡΠ΅ΡΠ°ΡΡΡΡ Π΄Π΅ΡΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈ, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ Π΄ΡΡΠ³ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΈ ΡΠΈΡΡΠ΅ΠΌ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° ΠΊ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³Ρ. ΠΠ°ΠΆΠ½ΠΎ ΠΏΠΎΠ½ΠΈΠΌΠ°ΡΡ, ΡΡΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΆΠΈ Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π΅Ρ Π½Π΅ΠΎΠ±ΡΠ°ΡΠΈΠΌΡΡ
ΠΎΡΠ³Π°Π½Π½ΡΡ
ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ, ΠΎΠ΄Π½Π°ΠΊΠΎ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠ° ΠΏΡΠ΅Π΅ΠΌΡΡΠ²Π΅Π½Π½ΠΎΡΡΡ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΌΠ΅ΠΆΠ΄Ρ Π΄Π΅ΡΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠΌ ΠΈ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠΌ. Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΠΠ
ΠΠ»ΠΈΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Ρ Π²ΠΎ Π²Π·Π²Π΅ΡΠΈ ΡΠ½Π΅ΠΆΠ½ΠΎ-Π»Π΅Π΄ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΡΠΎΠ²Π° ΠΠ΅Π»ΠΎΠ³ΠΎ ΠΌΠΎΡΡ
There are presented the results of multiyear research (2010, 2012 and 2015 and 2016) of aliphatic hydrocarbons and suspended matter in snow-ice cover of two regions of the White Sea: the Rugozerskaya bay (near the biological station of Moscow state University, the periphery of the Kandalaksha Bay) and the mouth of the Northern Dvina (near Archangelsk). Due to the atmospheric pollution in the heating season, hydrocarbon concentration increases, especially in the mouth of the Northern Dvina (up to 616 mg/l). In the ice, according to the conditions of ice formation, the concentration of the studied substances occurs in different parts of the core. In the top part of the ice the inο¬ ow of hydrocarbons with snow inο¬ uence hydrocarbon concentration and in the bottom part the main role plays the inο¬ ow with under-ice water, in particular, a big role goes to the processes on the border ice-water. A comparison of the obtained data with the results of the research of hydrocarbons was produced in snow and ice in the background areas of the Arctic.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΠ»Π΅ΡΠ½ΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ (2010, 2012, 2015 ΠΈ 2016 Π³Π³.) Π°Π»ΠΈΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Β ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄ΠΎΠ² ΠΈ Π²Π·Π²Π΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π° Π² ΡΠ½Π΅ΠΆΠ½ΠΎ-Π»Π΅Π΄ΡΠ½ΠΎΠΌ ΠΏΠΎΠΊΡΠΎΠ²Π΅ Π΄Π²ΡΡ
ΡΠ°ΠΉΠΎΠ½ΠΎΠ² ΠΠ΅Π»ΠΎΠ³ΠΎ ΠΌΠΎΡΡ: Π³ΡΠ±Ρ Π ΡΠ³ΠΎΠ·Π΅ΡΡΠΊΠΎΠΉ (ΡΠ°ΠΉΠΎΠ½ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ°Π½ΡΠΈΠΈ ΠΠΠ£ β ΠΠΠ‘, ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡ ΠΠ°Π½Π΄Π°Π»Π°ΠΊΡΡΠΊΠΎΠ³ΠΎ Π·Π°Π»ΠΈΠ²Π°) ΠΈ ΡΡΡΡΡ Π‘Π΅Π²Π΅ΡΠ½ΠΎΠΉ ΠΠ²ΠΈΠ½Ρ (ΡΠ°ΠΉΠΎΠ½ Π³. ΠΡΡ
Π°Π½Π³Π΅Π»ΡΡΠΊΠ°). Π ΡΠ½Π΅Π³Π΅, ΠΈΠ·-Π·Π° Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ Π°ΡΠΌΠΎΡΡΠ΅ΡΡ Π² ΠΎΡΠΎΠΏΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΠ΅Π·ΠΎΠ½, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄ΠΎΠ² ΠΏΠΎΠ²ΡΡΠ°Π»ΠΈΡΡ ΠΎΡ ΡΠ΅Π²ΡΠ°Π»Ρ ΠΊ ΠΌΠ°ΡΡΡ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π² ΡΡΡΡΠ΅ Π‘Π΅Π²Π΅ΡΠ½ΠΎΠΉ ΠΠ²ΠΈΠ½Ρ (Π΄ΠΎ 616 ΠΌΠΊΠ³/Π»). ΠΠΎ Π»ΡΠ΄Ρ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΡΠ»ΠΎΠ²ΠΈΠΉ Π»ΡΠ΄ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ Π² ΡΠ°Π·Π½ΡΡ
ΡΠ°ΡΡΡΡ
ΠΊΠ΅ΡΠ½Π°. Π Π²Π΅ΡΡ
Π½Π΅ΠΉ ΡΠ°ΡΡΠΈ Π»ΡΠ΄Π° Π½Π° ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄ΠΎΠ² ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΈΡ
ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠ΅ ΡΠΎ ΡΠ½Π΅Π³ΠΎΠΌ, Π° Π² Π½ΠΈΠΆΠ½Π΅ΠΉ β ΠΈΠ· ΠΏΠΎΠ΄Π»Π΅Π΄Π½ΠΎΠΉ Π²ΠΎΠ΄Ρ, ΠΏΡΠΈ ΡΡΠΎΠΌ Π±ΠΎΠ»ΡΡΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΡ Π½Π° Π³ΡΠ°Π½ΠΈΡΠ΅ Π»Π΅Π΄βΠ²ΠΎΠ΄Π°. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΠΎΠΏΠΎΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄ΠΎΠ² Π² ΡΠ½Π΅Π³Π΅ ΠΈ Π²ΠΎ Π»ΡΠ΄Ρ Π² ΡΠΎΠ½ΠΎΠ²ΡΡ
ΡΠ°ΠΉΠΎΠ½Π°Ρ
ΠΡΠΊΡΠΈΠΊΠΈ ΠΈ ΠΠ½ΡΠ°ΡΠΊΡΠΈΠΊΠΈ
(Table 7) Major and trace element concentrations in water samples obtained at varying distances from the Ob River bank
Geochemistry and radionuclide content of sediment and water samples obtained from the Ob and Irtysh river, Russia
This paper reports the results of the investigations of 2006-2007 on the distribution and migration forms of artificial radionuclides and chemical elements in the Ob-Irtysh water system. Three regions were studied. One of them is a local segment of the Ob River upstream from the confluence with the Irtysh River; its investigation allowed us to estimate the general radioecological state of the aquatic environment affected by the activity of the Tomsk 7 plant. The second region is a local segment of the Irtysh River upstream from its confluence with the Ob River, where the influence of emissions from the NPO Mayak could be estimated. The third region is the water area of the Ob River after its confluence with the Irtysh River. It characterizes the real level of radioactive and chemical contamination of the middle reaches of the Ob River. In order to explain horizontal variations in the distribution of radionuclides in the upper layer of bottom sediments collected at various sites, the results of sorption-kinetic experiments with radioactive tracers in the precipitate-solution system were used. The investigation of the migration forms of trace elements and radionuclides occurring in river water was based on the method of tangential-flow membrane filtration.
Chemical element contents were determined in 400-ml water samples. A set of Millipore polysulfone membranes with pore sizes of 8, 1.2, 0.45, 0.1, and 0.025 Β΅m was employed. Taking into account the ultralow specific concentrations of radionuclides in the water, they were analyzed in 300-500 litre samples using Millipore polysulfone membranes with pore sizes of 0.45 Β΅m and 15 kDa. This allowed us to estimate the percentages of cesium-137 and plutonium-239, 240 in the suspended particulate fraction, colloids, and dissolved species