Biofluid Biomarkers in Huntington's Disease

Huntington's disease (HD) is a chronic progressive neurodegenerative condition where new markers of disease progression are needed. So far no disease-modifying interventions have been found, and few interventions have been proven to alleviate symptoms. This may be partially explained by the lack of reliable indicators of disease severity, progression, and phenotype.Biofluid biomarkers may bring advantages in addition to clinical measures, such as reliability, reproducibility, price, accuracy, and direct quantification of pathobiological processes at the molecular level; and in addition to empowering clinical trials, they have the potential to generate useful hypotheses for new drug development.In this chapter we review biofluid biomarker reports in HD, emphasizing those we feel are likely to be closest to clinical applicability

Production of MA956 Alloy Reinforced Aluminum Matrix Composites by Mechanical Alloying

Aluminum matrix composites (AMC) are attractive structural materials for automotive and aerospace applications. Lightweight, environmental resistance, high specific strength and stiffness, and good wear resistance are promising characteristics that encourage research and development activities in AMC in order to extend their applications. Powder metallurgy techniques like mechanical alloying (MA) are an alternative way to design metal matrix composites, as they are able to achieve a homogeneous distribution of well dispersed particles inside the metal matrix. In this work, aluminum has been reinforced with particles of MA956, which is an oxide dispersion strengthened (ODS) iron base alloy (Fe-Cr-Al) of high Young¿s modulus and that incorporates a small volume fraction of nanometric yttria particles introduced by mechanical alloying. The aim of this work is to investigate the use of MA to produce AMC reinforced with 5 and 10 vol.% of MA956 alloy particles. Homogeneous composite powders were obtained after 20 h of milling. The evolution of morphology and particle size of composite powders was the typical observed in MA. The composite powders produced with 10 vol.% MA956 presented a more accentuated decrease in particle size during the milling, reaching 37 ¿m after 50 h. The thermal stability of the composite and the existence of interface reactions were investigated aiming further high temperature consolidation processing. Heat treatment at 420 °C resulted in partial reaction between matrix and reinforcement particles, while at 570 °C the extension of reaction was complete, with formation in both cases of Al-rich intermetallic phases.Peer Reviewe

The Effect of Air Exposure on the Hydrogenation Properties of 2Mg-Fe Composite after Mechanical Alloying and Accumulative Roll Bonding (ARB)

In this study, we successfully obtained a 2Mg-Fe mixture through mechanical alloying (MA) and processed it via accumulative roll bonding (ARB) (MA+ARB). Our primary focus was to analyze the impact of ambient air exposure while also evaluating the processing route. Some powder samples were exposed to air for 12 months (stored in a glass desiccator with an average yearly temperature and relative humidity of ~27 °C and 50.5%) before undergoing ARB processing. The Mg samples obtained after ARB processing exhibited a (002)-type texture. Our results demonstrate that all samples, including those processed via ARB, could rapidly absorb hydrogen within a matter of minutes despite considerable differences in surface area between powders and rolled samples. Grain size reduction by MA and ARB processing and texturing may have influenced this behavior. ARB-processed samples reached approximately 60% (~1.8 wt.%) of their maximum acquired capacity within just 24 min compared to powders (~2.2 wt.%) stored for a year, which took 36 min. In addition, the desorption temperatures (~300 °C) were lower than those of MgH2 (~434 °C). The absorption and desorption kinetics remained fast, even after prolonged exposure to air. Although there were minor variations in capacities, our overall findings are promising since scalable techniques such as ARB have the potential to produce hydrogen storage materials that are both safe and cost-effective in a highly competitive market