Defective phagocytic corpse processing results in neurodegeneration and can be rescued by TORC1 activation

This work was supported by NIH Grants R01 GM094452 (K.M.) and F31 GM099425 (J.I.E.), BU Alzheimer's Disease Core Center NIH Grant P30 AG13846, Boston University Undergraduate Research Opportunities Program grants (J.A.T., V.S.), and NIH Grant R01 AG044113 to M.B.F. We thank the Bloomington Stock Center, TRiP at Harvard Medical School, the Kyoto Drosophila Genetic Resource Center, Estee Kurant, Eric Baehrecke, Marc Freeman, and Mary Logan for fly strains. We thank Todd Blute for assistance with electron microscopy and the Developmental Studies Hybridoma Bank for antibodies. (R01 GM094452 - NIH; F31 GM099425 - NIH; R01 AG044113 - NIH; P30 AG13846 - BU Alzheimer's Disease Core Center NIH Grant; Boston University Undergraduate Research Opportunities Program)https://www.jneurosci.org/content/36/11/3170.longPublished versionPublished versio

Intern Self-Care: An Exploratory Study Into Strategy Use and Effectiveness

In this exploratory study, 363 interns were surveyed to assess the frequency of use and effectiveness of self-care strategies used during the internship year. Among the most frequently used strategies were family and friend social support, active problem solving, and humor. The most effective strategies were family and friend social support, seeking pleasurable experiences, and humor. A strong positive relationship was found between total scores for Frequency and Effectiveness subscales, and women reported significantly more use and effectiveness of strategies. Recommendations and resources are provided for interns and internship sites that seek to further understand and encourage intern self-care

The Design and Operation of The Keck Observatory Archive

The Infrared Processing and Analysis Center (IPAC) and the W. M. Keck Observatory (WMKO) operate an archive for the Keck Observatory. At the end of 2013, KOA completed the ingestion of data from all eight active observatory instruments. KOA will continue to ingest all newly obtained observations, at an anticipated volume of 4 TB per year. The data are transmitted electronically from WMKO to IPAC for storage and curation. Access to data is governed by a data use policy, and approximately two-thirds of the data in the archive are public.Comment: 12 pages, 4 figs, 4 tables. Presented at Software and Cyberinfrastructure for Astronomy III, SPIE Astronomical Telescopes + Instrumentation 2014. June 2014, Montreal, Canad

Collaboration Between Health Sciences Librarians and Faculty as Reflected by Articles Published in the Journal of the Medical Library Association

A recent study by Higgins and colleagues reports that the Journal of the Medical Library Association (JMLA) had the highest percentage of articles with both librarian and faculty co-authors out of 13 peer-reviewed journals in STEM librarianship and education between 2005 and 2014. A deeper and updated analysis of JMLA research articles and case studies published between 2008 and 2017 revealed that 29% of articles had both librarian and faculty co-authors. The main topics of librarian-faculty collaboration as described in these articles were related to patient and consumer health information and clinical information-seeking and decision-making by healthcare providers. Most faculty co-authors came from the disciplines of biomedical/health informatics and biostatistics and library and information science. The publication of these articles in JMLA provides evidence of health sciences librarians and information specialists’ ability to collaborate with faculty members to advance the knowledgebase and practice of librarianship and the health sciences

A Community-Engaged Oral History Study as a Tool for Understanding Environmental Justice Aspects of Human Exposures to Hazardous Waste Thermal Treatment Emissions in Colfax, LA

This study investigates environmental justice (EJ) themes related to siting a hazardous waste thermal treatment facility near a low-income community of color. We investigated effects of living near a hazardous waste thermal treatment facility through three EJ aspects: recognitional, procedural, and distributive justice. The study involved the collection of oral history interviews from residents of Colfax, a town in Grant Parish, Louisiana, that hosts an open burn/open detonation hazardous waste thermal treatment facility. The facility processes materials such as munitions, theme park waste, and contaminated soils from Superfund sites, and it increased its volume drastically in 2014. Residents reported adverse health conditions and exposure to air pollutants. We analyzed how the three themes of EJ emerged from the interviews using the NVivo coding software. We recorded narratives that described substantial changes around people\u27s identity, health, and social experiences after the facility\u27s increase in operations. Residents described a peaceful and clean community before the facility\u27s construction in 1980. Some residents stated that the community had not been consulted when the facility was established or when its operations were increased. Colfax residents\u27 narratives jointly relay a proud history of community connections and homeownership that was undermined by environmental health hazards created by the facility and by their exclusion from local and state government decisions about the facility\u27s placement

Cornea As a Model for Testing CTGF-Based Antiscarring Drugs

Scarring remains a serious complication of the wound healing process that can lead to the formation of excessive fibrous connective tissue in an organ or tissue leading to pain and loss of function. This process is mainly regulated by Transforming growth factor β1 (TGF-β1), which binds to receptors and induces its downstream mediator, Connective tissue growth factor (CTGF). The number of drugs targeting CTGF for treating scars has been on the rise in the past few years. The purpose of this article is to suggest the possibility of using cornea as a model for testing anti-CTGF therapies for scarring

Two complex orthogonal space-time codes for eight transmit antennas

Two new constructions of complex orthogonal space-time block codes of order 8 based on the theory of amicable orthogonal designs are presented and their performance compared with that of the standard code of order 8. These new codes are suitable for multi-modulation schemes where the performance can be sacrificed for a higher throughput