789 research outputs found

    A Comparison of the Wishes of Hospitalized Patients Regarding Prayer From Healthcare Professionals in Religious Based and Non Religious Based Healthcare Facilities

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    Aim This paper examines patientā€™s desire for prayer from their health care providers and looks at the difference in prayer frequency between religious and non-religious based hospitals. Background Continued debate surrounds this concept: How much spiritual care should be integrated into the medical field? Many theorists have included spirituality as an integral part to holistic care. Therefore healthcare providers should address prayer and spirituality. Method A convenience sampling of 93 patients was taken from a government and a religious based hospital in southeastern Tennessee. The questionnaire used was specifically designed for the study. Information collected included demographics, religious affiliation, habits and prayer desires in relationship to the healthcare they received. Findings A statistically significant difference was found between the prayer activities of the chaplains at the two facilities (Ļ‡2 = .002, P \u3c0 \u3e.05), with greater frequency of prayer with patients at the religious based hospital. No statistical significance was found in the prayer activity of the doctors, nurse practitioners, physician assistants, nurses and nursing assistants between the two facilities. Data revealed that patients frequently desired prayer and these needs were not met. Conclusion Patientā€™s spirituality must be addressed; healthcare providers need to strive to better meet patients spiritual and prayer needs. In many circumstances patients desire their healthcare providers to offer prayer

    Media literacy instruction in todayā€™s classrooms: A study of teachersā€™ knowledge, confidence, and integration

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    Teachers play a critical role in helping to ensure that students leave school with the skills needed to not only be critical consumers of media, but to also be thoughtful and knowledgeable producers of mediated messages. Despite the important role of teachers in media literacy education, we still know very little about teachersā€™ knowledge of and experiences with media literacy in the classroom. This information is a critical piece in understanding how to best support teachers as they integrate media literacy education within PreK-12 classrooms. The current study seeks to add to the growing body of research in this area by examining secondary teachersā€™ knowledge of media literacy, confidence incorporating it in classes, and actual integration of media literacy education in courses. Results of a survey of 71 teachers found a relationship between knowledge, confidence, and integration of media literacy. Implications of the study results are discussed

    District-wide Instructional Initiative Framework

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    Describes the Bank Street Education Center\u27s District-wide Instructional Initiative Framework, a tool that guides the Center\u27s partnership work with school districts who are engaged in a process of instructional improvement. The Framework was developed out of research on district improvement, organizational development, school leadership, and professional learning, as well as the Center\u27s own experience implementing large-scale district reform in the largest school district in the nation: New York City.https://educate.bankstreet.edu/faculty-staff/1021/thumbnail.jp

    Prospectus, February 21, 1996

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    https://spark.parkland.edu/prospectus_1996/1005/thumbnail.jp

    The Functionality Appreciation Scale (FAS):Development and psychometric evaluation in US community women and men

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    Body functionality has been identified as an important dimension of body image that has the potential to be useful in the prevention and treatment of negative body image and in the enhancement of positive body image. Specifically, cultivating appreciation of body functionality may offset appearance concerns. However, a scale assessing this construct has yet to be developed. Therefore, we developed the Functionality Appreciation Scale (FAS) and examined its psychometric properties among three online community samples totalling 1042 women and men (ns = 490 and 552, respectively). Exploratory factor analyses revealed a unidimensional structure with seven items. Confirmatory factor analysis upheld its unidimensionality and invariance across gender. The internal consistency, test-retest reliability, criterion-related, and construct (convergent, discriminant, incremental) validity of its scores were upheld. The FAS is a psychometrically sound measure that is unique from existing positive body image measures. Scholars will find the FAS applicable within research and clinical settings

    A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance

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    In the initial scale-up batches of the experimental drug substance AMG 517, a pair of unexpected impurities was observed by HPLC. Analysis of data from initial LC-MS experiments indicated the presence of two dimer-like molecules. One impurity had an additional sulfur atom incorporated into its structure relative to the other impurity. Isolation of the impurities was performed, and further structural elucidation experiments were conducted with high-resolution LC-MS and 2D NMR. The dimeric structures were confirmed, with one of the impurities having an unexpected C-S-C linkage. Based on the synthetic route of AMG 517, it was unlikely that these impurities were generated during the last two steps of the process. Stress studies on the enriched impurities were carried out to further confirm the existence of the C-S-C linkage in the benzothiazole portion of AMG 517. Further investigation revealed that these two dimeric impurities originated from existing impurities in the AMG 517 starting material, N-acetyl benzothiazole. The characterization of these two dimeric impurities allowed for better quality control of new batches of the N-acetyl benzothiazole starting material. As a result, subsequent batches of AMG 517 contained no reportable levels of these two impuritie

    Ketogenic diets and thermal pain: dissociation of hypoalgesia, elevated ketones, and lowered glucose in rats [post-print]

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    Ketogenic diets (KDs) are high-fat, low-carbohydrate formulations effective in treating medically refractory epilepsy, and recently we demonstrated lowered sensitivity to thermal pain in rats fed a KD for 3 to 4 weeks. Regarding anticonvulsant and hypoalgesic mechanisms, theories are divided as to direct effects of increased ketones and/or decreased glucose, metabolic hallmarks of these diets. To address this point, we characterized the time course of KD-induced thermal hypoalgesia, ketosis, and lowered glucose in young male rats fed ad libitum on normal chow or KDs. A strict 6.6:1 (fat:[carbohydrates + protein], by weight) KD increased blood ketones and reduced blood glucose by 2 days of feeding, but thermal hypoalgesia did not appear until 10 days. Thus, ketosis and decreased glucose are not sufficient for hypoalgesia. After feeding a 6.6:1 KD for 19 days, decreased thermal pain sensitivity and changes in blood chemistry reversed 1 day after return to normal chow. Effects were consistent between 2 different diet formulations: a more moderate and clinically relevant KD formula (3.0:1) produced hypoalgesia and similar changes in blood chemistry as the 6.6:1 diet, thus increasing translational potential. Furthermore, feeding the 3.0:1 diet throughout an extended protocol (10ā€“11 weeks) revealed that significant hypoalgesia and increased ketones persisted whereas low glucose did not, demonstrating that KD-induced hypoalgesia does not depend on reduced glucose. In separate experiments we determined that effects on thermal pain responses were not secondary to motor or cognitive changes. Together, these findings dissociate diet-related changes in nociception from direct actions of elevated ketones or decreased glucose, and suggest mechanisms with a slower onset in this paradigm. Overall, our data indicate that metabolic approaches can relieve pain

    Investigating the Effects of Stress on Cognitive and Emotional Moral Decision Making

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    The dual-process theory accounts for how moral judgments are made: personal emotional dilemmas and impersonal cognitive dilemmas (Greene, 2007). In the Fisher and Ravizza (1992) Trolley Problem personal dilemma, you stop a runaway trolley and save all the workmen by pushing and killing one person on the tracks. In the Trolley Problem impersonal dilemma, you divert a runaway trolley and save all the workmen by throwing a switch and diverting the trolley killing one person on the tracks. In support of the dual-process theory, brain imaging research has demonstrated that brain regions linked with emotion (e.g., amygdala) are activated during the personal dilemmas, and brain regions associated with working memory (prefrontal cortex, parietal lobe) are activated during the impersonal dilemmas. Stress can interfere with rational, deliberative processes, causing decision-makers to rely on intuitive, automatic processes. In the present study, we are including two stressful conditions - physiological and cognitive - in order to see if stress has a differential effect on utilitarian decisions. Participants listened to moral dilemmas while experiencing baseline, stressor and control conditions. Stress was self-reported on an 11-point scale. Significance was found in utilitarian decisions, with the majority of participants reporting it ā€œwas appropriate to killā€ during baseline and cognitive stress (i.e., counting backwards). Participants reported it was ā€œnot appropriate to killā€ during physiological stress (i.e., cold pressor task). In addition, participants reported more stress during cognitive stress and more pain during physiological stress. In conclusion, utilitarian decision making seems to be affected when experiencing physiological stress

    Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies

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    INTRODUCTION: Administration of mesenchymal stem cells (MSCs) has been shown to improve renal function in rodent models of chronic kidney disease (CKD), in part by reducing intrarenal inflammation and suppressing fibrosis. CKD in cats is characterized by tubulointerstitial inflammation and fibrosis, and thus treatment with MSCs might improve renal function and urinary markers of inflammation in this disease. Therefore, a series of pilot studies was conducted to assess the safety and efficacy of intravenous administration of allogeneic adipose-derived MSCs (aMSCs) in cats with naturally occurring CKD. METHODS: Cats enrolled in these studies received an intravenous infusion of allogeneic aMSCs every 2 weeks collected from healthy, young, specific pathogen-free cats. Cats in pilot study 1 (six cats) received 2 Ɨ 10(6) cryopreserved aMSCs per infusion, cats in pilot study 2 (five cats) received 4 Ɨ 10(6) cryopreserved aMSCs per infusion, and cats in pilot study 3 (five cats) received 4 Ɨ 10(6) aMSCs cultured from cryopreserved adipose. Serum biochemistry, complete blood count, urinalysis, urine protein, glomerular filtration rate, and urinary cytokine concentrations were monitored during the treatment period. Changes in clinical parameters were compared statistically by means of repeated measures analysis of variance (ANOVA) followed by Bonferroniā€™s correction. RESULTS: Cats in pilot study 1 had few adverse effects from the aMSC infusions and there was a statistically significant decrease in serum creatinine concentrations during the study period, however the degree of decrease seems unlikely to be clinically relevant. Adverse effects of the aMSC infusion in cats in pilot study 2 included vomiting (2/5 cats) during infusion and increased respiratory rate and effort (4/5 cats). Cats in pilot study 3 did not experience any adverse side effects. Serum creatinine concentrations and glomerular filtration rates did not change significantly in cats in pilot studies 2 and 3. CONCLUSIONS: Administration of cryopreserved aMSCs was associated with significant adverse effects and no discernible clinically relevant improvement in renal functional parameters. Administration of aMSCs cultured from cryopreserved adipose was not associated with adverse effects, but was also not associated with improvement in renal functional parameters
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