630 research outputs found
Erythrocyte Antibodies in AIDS are associated with mycobacteriosis and hypergammaglobulinemia
Quantum magneto-optics of graphite family
The optical conductivity of graphene, bilayer graphene, and graphite in
quantizing magnetic fields is studied. Both dynamical conductivities,
longitudinal and Hall's, are analytically evaluated. The conductivity peaks are
explained in terms of electron transitions. We have shown that trigonal warping
can be considered within the perturbation theory for strong magnetic fields
larger than 1 T and in the semiclassical approach for weak fields when the
Fermi energy is much larger than the cyclotron frequency. The main optical
transitions obey the selection rule with \Deltan = 1 for the Landau number n,
however the \Deltan = 2 transitions due to the trigonal warping are also
possible. The Faraday/Kerr rotation and light transmission/reflection in the
quantizing magnetic fields are calculated. Parameters of the
Slonczewski-Weiss-McClure model are used in the fit taking into account the
previous dHvA measurements and correcting some of them for the case of strong
magnetic fields.Comment: 28 pages, 12 figures. arXiv admin note: text overlap with
arXiv:1106.340
Inclusive Dielectron Cross Sections in p+p and p+d Interactions at Beam Energies from 1.04 to 4.88 GeV
Measurements of dielectron production in p+p and p+d collisions with beam
kinetic energies from 1.04 to 4.88 GeV are presented. The differential cross
section is presented as a function of invariant pair mass, transverse momentum,
and rapidity. The shapes of the mass spectra and their evolution with beam
energy provide information about the relative importance of the various
dielectron production mechanisms in this energy regime. The p+d to p+p ratio of
the dielectron yield is also presented as a function of invariant pair mass,
transverse momentum, and rapidity. The shapes of the transverse momentum and
rapidity spectra from the p+d and p+p systems are found to be similar to one
another for each of the beam energies studied. The beam energy dependence of
the integrated cross sections is also presented.Comment: 15 pages and 16 figure
Role of Interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression
Background:
The use of TNF inhibitors has been a major progress in the treatment of chronic inflammation. However, not all patients respond. In addition, response will be often lost when treatment is stopped. These clinical aspects indicate that other cytokines might be involved and we focus here on the role of IL-17. In addition, the chronic nature of joint inflammation may contribute to reduced response and enhanced chronicity. Therefore we studied the capacity of IL-17 to regulate synoviolin, an E3 ubiquitin ligase implicated in synovial hyperplasia in human rheumatoid arthritis (RA) FLS and in chronic reactivated streptococcal cell wall (SCW)-induced arthritis.<p></p>
Methodology/Principal Findings:
Chronic reactivated SCW-induced arthritis was examined in IL-17R deficient and wild-type mice. Synoviolin expression was analysed by real-time RT-PCR, Western Blot or immunostaining in RA FLS and tissue, and p53 assessed by Western Blot. Apoptosis was detected by annexin V/propidium iodide staining, SS DNA apoptosis ELISA kit or TUNEL staining and proliferation by PCNA staining. IL-17 receptor A (IL-17RA), IL-17 receptor C (IL-17-RC) or synoviolin inhibition were achieved by small interfering RNA (siRNA) or neutralizing antibodies. IL-17 induced sustained synoviolin expression in RA FLS. Sodium nitroprusside (SNP)-induced RA FLS apoptosis was associated with reduced synoviolin expression and was rescued by IL-17 treatment with a corresponding increase in synoviolin expression. IL-17RC or IL-17RA RNA interference increased SNP-induced apoptosis, and decreased IL-17-induced synoviolin. IL-17 rescued RA FLS from apoptosis induced by synoviolin knockdown. IL-17 and TNF had additive effects on synoviolin expression and protection against apoptosis induced by synoviolin knowndown. In IL-17R deficient mice, a decrease in arthritis severity was characterized by increased synovial apoptosis, reduced proliferation and a marked reduction in synoviolin expression. A distinct absence of synoviolin expressing germinal centres in IL-17R deficient mice contrasted with synoviolin positive B cells and Th17 cells in synovial germinal centre-like structures.<p></p>
Conclusion/Significance:
IL-17 induction of synoviolin may contribute at least in part to RA chronicity by prolonging the survival of RA FLS and immune cells in germinal centre reactions. These results extend the role of IL-17 to synovial hyperplasia.<p></p>
Event-by-event fluctuations of the kaon to pion ratio in central Pb+Pb collisions at 158 GeV per Nucleon
We present the first measurement of fluctuations from event to event in the
production of strange particles in collisions of heavy nuclei. The ratio of
charged kaons to charged pions is determined for individual central Pb+Pb
collisions. After accounting for the fluctuations due to detector resolution
and finite number statistics we derive an upper limit on genuine
non-statistical fluctuations, perhaps related to a first or second order QCD
phase transition. Such fluctuations are shown to be very small.Comment: 4 pages, 2 figure
Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial
© Cuzick et al. Open Access article distributed under the terms of CC BY.http://dx.doi.org/10.1016/S1470-2045(14)71171-
Baryon Stopping and Charged Particle Distributions in Central Pb+Pb Collisions at 158 GeV per Nucleon
Net proton and negative hadron spectra for central \PbPb collisions at 158
GeV per nucleon at the CERN SPS were measured and compared to spectra from
lighter systems. Net baryon distributions were derived from those of net
protons, utilizing model calculations of isospin contributions as well as data
and model calculations of strange baryon distributions. Stopping (rapidity
shift with respect to the beam) and mean transverse momentum \meanpt of net
baryons increase with system size. The rapidity density of negative hadrons
scales with the number of participant nucleons for nuclear collisions, whereas
their \meanpt is independent of system size. The \meanpt dependence upon
particle mass and system size is consistent with larger transverse flow
velocity at midrapidity for \PbPb compared to \SS central collisions.Comment: This version accepted for publication in PRL. 4 pages, 3 figures.
Typos corrected, some paragraphs expanded in response to referee comments, to
better explain details of analysi
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