Examination of the Relationship between Certain Gene Variations and Psychological Factors with Physical Activity Level in the Individuals with the Diagnosis of Schizophrenia and Bipolar Disorders

The research aims to examine certain gene variations and to examine relationship between psychological factors and activity levels by the individuals with schizophrenia and bipolar diagnosis. This research has been conducted with the participation of the patients with schizophrenia and bipolar diagnosis in the Mental Facility of Bursa Dört Çelik at the University of Health Science and all the patients take part in physical exercise activities regularly. During the research, IPAQ has been applied to determine participants’ physical activity levels whereas Beck’s Depression Inventory, Beck’s Anxiety Inventory, Staı Form TX-I-II, Beck’s Hopelessness Index has been applied to determine their psychological status after socio-demographic information of participants was obtained by demographic form. In order to examine properties of the participants genetically, oral swabs were obtained by SWAP kite. Genetic variations of cases have been recurred as a result of genotyping analysis of MAO-A, COMT, TH and SLC6A4 genes in GenoFeel panel by using isolated DNAs yielded from swap samples. When the results obtained from statistical analysis are analyzed, it has been seen that genetic properties pair with psychological factor meanwhile the characteristics of diseases bear a resemblance to these measurement. It was determined in this research that, genetic factor were matched with psychological factors, these measurement results resembled with the characteristic of diagnosed ailments as well and schizophrenia and bipolar patients have significance in MAO-A and COMT figures, excessive activation of TH (tyrosine hydroxylase) enzyme may also be included in excessive dopamine production, Homozygote mutation and heterozygote genotypes of gene which is related to SLC6A has rational increase whereas no significance was observed in schizophrenia patient’s group. As a consequence it shouldn’t be neglected that exercising should be a part of schizophrenia and bipolar patients’ life, that exercise, genetic parameters and psychological tests have positive contributions for treatments and that medical treatment has positive contributions with exercise

The effect of halofuginone on radiation-induced cardiovascular injury

Purpose: The main purpose of this study was to evaluate the effects of Halofuginone on radiation-induced cardiovascular injury in a rat model. Methods: Sixty Wistar-Albino rats were divided into six groups (the control group, radiotherapy (RT) only group Irradiation (IR), 2.5 and 5 μg Halofuginone groups (Hal (2.5)/C and Hal (5.0)/C), and RT plus 2.5 and 5 μg Halofuginone groups (Hal (2.5)/IR and Hal (5.0)/IR). Rats were exposed to a single dose of 12 Gy irradiation generated by a linear accelerator. Halofuginone was applied intraperitoneally with daily doses. At the 6th and 16th weeks of RT, 5 rats from each group sacrificed and; heart and thoracic aorta tissues removed for both light microscopic and electron microscopic examinations. Results: Light microscopic examinations revealed that the endocardial thickness of all study groups was significantly different at 6th and 16th week of RT (p < 0.001 for both). Pair-wise comparisons showed that the differences were significant in IR- Hal (2.5)/IR (p < 0.001); IR-Hal (5.0)/IR (p < 0.001); and Hal (2.5)/IR-Hal (5.0)/IR (p = 0.001) at 16th week of RT. There were significant differences within the study groups regarding to the thoracic aorta fibrosis scores only at 16th week of RT (p = 0.002). Electron microscopic examinations demonstrated that there were significant differences between all the groups with respect to heart mitochondria scores at both 6th week and 16th weeks of RT (p < 0.001 for both). The differences between Hal (2.5)/IR and Hal (5.0)/IR with respect to the heart mitochondria scores were significant only at 16th week of RT (p = 0.001). Conclusion: These data demonstrated that Halofuginone may improve radiation-induced cardiovascular injury. The most prominent improvement was observed in higher dose of Halofuginone group after long term follow-up

Folliculotropic mycosis fungoides associated with alopecia in a case

Mycosis fungoides (MF) is the most common type of cutaneous lymphoma and characterized by proliferation of small to medium T lymphocytes with cerebriform nuclei in most cases. However, the diagnosis of MF may be very difficult in certain cases, particularly in those variants of MF such assyringotropic MF, granulomatous MF and folliculotropic MF. The classic histopathologic feature is the presence of atypical T-cells with a tropism to hair follicle epithelium. The clinical presentation of folliculotropic MF often differs from the patches and plaques of classic MF and may be associated with decreased clinical suspicion for folliculotropic MF. The average time interval from onset of lesions till diagnosis of folliculotropic MF was 2 years. Folliculotropic MF displays resistance to standard treatment modalities, has an unfavourable course and diversity in the histological spectrum. Here we reported a rare case who presented to our dermatology polyclinic with a complaint of hair loss on his back firstly. On the follow-up, the case was diagnosed as folliculotropic MF and treated with interferon-i2a and PUVA successfully.Mikozis fungoides (MF); birçok olguda, küçük ve orta boyuttaki serebriform çekirdekçikleres sahip T lenfositlerinin çoğalmasıyla karakterize en sık olarak görülen kutanöz lenfoma tipidir. Bu-n unla birlikte; özellikle asiringotropik, granülomatöz ve follikülotropik MF gibi olgularda tanı koy-m ak güç olabilmektedir. Folikülotropik MF’de klasik histopatolojik görünüm; atipik T hücrelerininf olliküler epitele tropizmi ile karakterizedir. Folikülotropik MF’in klinik görünümü özellikle kla-s ik MF’de görülen yama ve plaklardan farklılık arz etmektedir ve bu durum da klinik olarak foli-k ülotropik MF öntanısını güçleştirmektedir. Hastalığın başladığı dönemle tanı arasındaki süreo rtalama 2 yıldır. Folikülotropik MF, standart tedavi seçeneklerine dirençlidir, istenmeyen klinikg idişata sahiptir ve histopatolojik olarak farklılıklar arz etmektedir. Biz burada; sırtta kıl dökülena lanlar şikayeti ile polikliniğimize başvuran, takiplerinde Folikülotropik MF gelişen ve PUVA ve in-t erferon- α2a ile başarıyla tedavi edilen oldukça nadir görülen bir olguyu sunduk

Polikistik over sendromu olan kadınlarda psikiyatrik belirtiler

Amaç: Yayınların çoğunda polikistik over sendromuna (PKOS) psikiyatrik hastalıkların eşlik ettiği, özellikle depresyon ve kaygı bozukluklarının daha yüksek düzeyde görüldüğü bildirilmiştir. PKOS’da artan testosteron miktarı sebebiyle kıllanmada artış, adet düzensizlikleri, sivilcelenme, kısırlık, obezite gibi semptomlar görülmektedir. Bu şikayetler, çoğunlukla olumsuz duygulanıma sebep olurlar. Bunlarla birlikte, psikiyatrik belirtilerin görülme riski artar. Biz, çalışmamızda PKOS tanısı alan hastalarda, diğer kadınlara oranla psikiyatrik belirtilerin görülme düzeyini ve bunun cinsiyet yönelimiyle ilişkisini araştırdık. Yöntem: Çalışmaya, Meram Tıp Fakültesi Hastanesi Kadın Doğum Hastalıkları Polikliniği’ne gelen 42 PKOS tanısı almış hasta ve kıyaslama yapabilmek için, 42 sağlıklı veya adet düzensizliği, sivilcelenme veya kıllanma artışı olmayan gönüllü kadın alındı. Kontrol grubu ve çalışma grubunun sosyodemografik özellikleri birbirine benzemekteydi. Her iki gruba da araştırmacıların hazırladığı sosyodemografik form, Kısa Semptom Envanteri ve Bem Cinsiyet Rolü Envanteri uygulandı. Bulgular: PKOS tanılı hastalarda, kontrol grubuna kıyasla depresyon, kaygı bozukluğu, somatizasyon, kişilerarası ilişkilerde duyarlılık artışı, obsesif kompulsif bozukluk, fobik anksiyete, paranoid düşünce düzeyi daha yüksek bulunurken, hostilite ve psikotik bulguların düzeyleri arasında fark bulunamamıştır. Psikiyatrik belirtilerin görülmesinde cinsiyet yöneliminin etkisi olmadığı görülmüştür. Sonuç: PKOS tanılı hasta grubunda, literatür bilgilerini destekler biçimde, kontrol grubuna göre daha fazla düzeyde psikiyatrik belirtiler görülmektedir. Kadın hastalıkları ve doğum polikliniklerinde bu hastaların daha dikkatli incelenerek psikiyatri polikliniklerine yönlendirilmeleri hastaların yaşam kalitelerini olumlu yönde etkileyecektir.Psychiatric symptoms in women with polycystic ovary syndrome Objective: Most of the articles in the literature state that polycystic ovary syndrome (PCOS) is mostly accompanied by psychiatric diseases, and especially, depression and anxiety disorder are seen more frequently in cases of PCOS. With the increase in the level of testosterone in PCOS, many symptoms, such as hirsutism, menstrual irregularity, acne formation, infertility, and obesity appear. These complaints mostly cause negative affect, and the risk for psychiatric symptoms increases. In this study, we compared the level of psychiatric symptoms in women diagnosed with PCOS and healthy women, and investigated its relationship with gender orientation. Methods: The study included 42 PCOS patients from Meram Medical School, and a group of 42 healthy women, without menstrual irregularity, acne formation and hirsutism who volunteered to participate in the study. Both groups were similar according to sociodemographic features. Both groups were administered a sociodemographic form prepared by the researchers as well as the Short Symptom Inventory and Bem Sex Role Inventory. Results: Depression, anxiety disorder, somatization, increased susceptibility in interpersonal relations, obsessive compulsive disorder, phobic anxiety, paranoid thoughts were more frequent in the PCOS group. On the other hand, the level of hostility and psychotic symptoms were similar in both groups. Conclusion: Psychiatric symptoms were more frequent in the PCOS group, which is consistent with the literature. It is expected that the life quality of PCOS patients will change positively if they are investigated more carefully in the obstetrics and gynecology outpatient clinics and directed to psychiatry outpatient clinics

Memenin inflamatuvar psödotümörü: Nadir bir olgu

Memenin inflamatuar psödotümörü (MIP) çok nadir bir durumdur. Lite- ratürde sınırlı sayıda olgu bildirilmiştir. Patogenezi tartışmalı bir konudur. Memenin inflamatuvar psödotümörü ön tanısıyla rezeksiyon yapılan 65 yaşında bir kadın hasta irdelendi. Sağ memesinde ağrısız kitle yakınması ile kliniğimize başvurdu. Görüntüleme eşliğinde tru-cut biyopsi yapıldı. Tru- cut biyopsi sonrası patolojik bulgular inflamatuvar psödotümörle uyumluy- du. Lokal eksizyon işelemi uygulandı. Yirmi dört aylık takiplerinde nüks saptanmadı.Inflammatory pseudotumor of the breast (IPB) is a very rare condition. Literature reports a limited number of cases. Its pathogenesis is also a con- troversial issue. Within the scope of our study, a 65-year-old female patient, who had resection because of inflammatory pseudotumor of the breast, was evaluated. The patient presented to our clinic with complaints of a painless mass in her right breast. Imaging guided tru-cut biopsy was performed. The pathological findings following the tru-cut biopsy were consistent with inflammatory pseudotumor. Local excision was performed. There was no recurrence during the 24-month follow-ups

Neutrophilic figurate erythema

We herein report a 39-year-old woman presented with annular plaque with central clearing on the back, extremities, and breasts. The lesions had raised, firm erythematous borders included a trailing scale. On histologic examination, a perivascular inflammatory cell infiltrate composed of neutrophils and mononuclear inflammatory cells in the upper dermis was shown. We consider our case to represent idiopathic figurate erythema with a dominant infiltration of neutrophils