Récupération et basket-ball : la préparation terminale du championnat d'Europe cadets, 1997

Legrand Lucien, Touzé Jean-Marc. Récupération et basket-ball : la préparation terminale du championnat d'Europe cadets, 1997. In: Les Cahiers de l'INSEP, n°27, 2000. Sport de haut niveau et récupération. pp. 231-238

Publisher Correction: An LDV based method to quantify the error of PC-MRI derived Wall Shear Stress measurement

An amendment to this paper has been published and can be accessed via a link at the top of the paper

High-resolution MR imaging of the cervical arterial wall:what the radiologist needs to know.

International audienc

Functional and Structural Characterization of PaeM, a Colicin M-like Bacteriocin Produced by Pseudomonas aeruginosa

International audienceColicin M (ColM) is the only enzymatic colicin reported to date that inhibits cell wall peptidoglycan biosynthesis. It catalyzes the specific degradation of the lipid intermediates involved in this pathway, thereby provoking lysis of susceptible Escherichia coli cells. A gene encoding a homologue of ColM was detected within the exoU-containing genomic island A carried by certain pathogenic Pseudomonas aeruginosa strains. This bacteriocin (pyocin) that we have named PaeM was crystallized, and its structure with and without an Mg2+ ion bound was solved. In parallel, site-directed mutagenesis of conserved PaeM residues from the C-terminal domain was performed, confirming their essentiality for the protein activity both in vitro (lipid II-degrading activity) and in vivo (cytotoxicity against a susceptible P. aeruginosa strain). Although PaeM is structurally similar to ColM, the conformation of their active sites differs radically; in PaeM, residues essential for enzymatic activity and cytotoxicity converge toward a same pocket, whereas in ColM they are spread along a particularly elongated active site. We have also isolated a minimal domain corresponding to the C-terminal half of the PaeM protein and exhibiting a 70-fold higher enzymatic activity as compared with the full-length protein. This isolated domain of the PaeM bacteriocin was further shown to kill E. coli cells when addressed to the periplasm of these bacteria

Militaires en République, 1870-1962

Du maréchal de MacMahon au général de Gaulle, militaires et hommes politiques entretiennent des relations dominées par une mutuelle incompréhension et une large suspicion. Les premiers accusent les poli­tiques de diviser les Français en professionnels de la chicane, quand les seconds suspectent nombre d’officiers de rêver au renversement de la République. Ce livre dépasse les stéréotypes habituels. En une cinquantaine de contributions, il étudie toutes les formes de participation des officiers au pouvoir et à la vie publique, de rétablissement de la Troisième République aux débuts de la Cinquième, de la fin de la guerre de 1870-1871 à la conclusion du conflit algérien. Le métier des armes est, par essence, de nature politique en ce qu’il participe de la conduite de la cité. Certes la professionnalisation de l’action politique sans parler de la peur qu’inspire aux républicains le césarisme a contribué à maintenir les officiers dans les limites de l’expertise. Mais les grands chefs, au même titre qu’une poignée de hauts fonctionnaires, participent au pouvoir par leur contribution à la définition de la politique de défense et de certains aspects de la politique extérieure. Par une approche pluridisciplinaire, associant historiens, juristes, poli­tiques et sociologues, universitaires et militaires, ce colloque rompt défi­nitivement avec l’image simpliste de deux mondes étanches l’un à l’autre et renouvelle l’étude des relations entre les officiers et la vie politique

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke

BACKGROUND AND PURPOSE: The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation, has attracted considerable attention in the literature. In this context, we present a retrospective pooled analysis of a large dataset from pre-clinical studies, in order to examine the effects of early versus late administration of intravenous recombinant tissue type plasminogen activator (rt-PA). METHODS: We collected data from 26 individual studies from 9 international centers (13 researchers, 716 animals) that compared rt-PA to controls, in a unique mouse model of thromboembolic stroke induced by an in situ injection of thrombin into the middle cerebral artery. Studies were classified into early (<3h) versus late (≥3h) drug administration. Final infarct volumes, assessed by histology or MRI, were compared in each study and the absolute differences were pooled in a random-effect meta-analysis. The influence of time of administration was tested. RESULTS: When compared to saline controls, early rt-PA administration was associated with a significant benefit (absolute difference = −6.63 mm(3); 95%CI, −9.08 to −4.17; I(2)=76%) whereas late rt-PA treatment showed a deleterious effect (+5.06 mm(3); 95%CI, +2.78 to +7.34; I(2)=42%, P(int)<0.00001). Results remained unchanged following subgroup analyses. CONCLUSION: Our results provide the basis needed for the design of future pre-clinical studies on recanalization therapies using this model of thromboembolic stroke in mice. The power analysis reveals that a multi-center trial would require 123 animals per group instead of 40 for a single center trial