Dupilumab Drug Survival and Associated Predictors in Patients With Moderate to Severe Atopic Dermatitis Long-term Results From the Daily Practice BioDay Registry

IMPORTANCE Long-term data on dupilumab drug survival in patients with atopic dermatitis (AD) are scarce. Furthermore, little is known about the factors associated with drug survival of dupilumab in AD.OBJECTIVE To describe the drug survival of dupilumab in patients with AD and to identify associated predictors.DESIGN, SETTING, AND PARTICIPANTS This cohort studywas based on data from the multicenter prospective daily practice BioDay registry, in which 4 university and 10 nonuniversity hospitals in the Netherlands participated. Analysis included patients (age &gt;= 18 years) participating in the BioDay registry with a follow-up of at least 4 weeks. The first patient treated with dupilumab was recorded in the BioDay registry in October 2017; data lock took place in December 2020, and data analysis was performed from October 2017 to December 2020.MAIN OUTCOMES AND MEASURES Drug survivalwas analyzed by Kaplan-Meier survival curves and associated characteristics by using univariate and multivariate Cox regression analysis.RESULTS A total of 715 adult patients with AD (mean [SD] age, 41.8 [16.0] years; 418 [58.5%] were male) were included with a 1-year, 2-year, and 3-year overall dupilumab drug survival of 90.3%, 85.9%, and 78.6%, respectively. Characteristics associated with shorter drug survival owing to ineffectiveness were the use of immunosuppressant drugs at baseline (hazard ratio [HR], 2.64; 95% CI, 1.10-6.37) and being a nonresponder at 4 weeks (HR, 8.68; 95% CI, 2.97-25.35). Characteristics associated with shorter drug survival owing to adverse effects were the use of immunosuppressant drugs at baseline (HR, 2.69; 95% CI, 1.32-5.48), age 65 years or older (HR, 2.94; 95% CI, 1.10-7.87), and Investigator Global Assessment score of very severe AD (HR, 3.51; 95% CI, 1.20-10.28).CONCLUSIONS AND RELEVANCE This cohort study demonstrated a good overall 1-year, 2-year, and 3-year dupilumab drug survival. Patients using immunosuppressive therapy at baseline and those with an absence of treatment effect at week 4 tended to discontinue treatment owing to ineffectiveness more frequently. Using immunosuppressant drugs at baseline, older age, and Investigator Global Assessment score of very severe AD were characteristics associated with an increased risk for discontinuation owing to adverse effects. These data provide more insight and new perspectives regarding dupilumab treatment in AD and can contribute to the optimization of patient outcomes.</p

Digitale geletterdheid, een nieuwe cursus media en een app die verliefdheid meet.

Kritisch leren kijken naar media, naar betrouwbaarheid van bronnen én naar technologie. Het zijn onmisbare vaardigheden in de digitale wereld, waarin informatie met één druk op de knop te vinden is. Gelukkig kun je al die vaardigheden leren: “Digitale geletterdheid is het vermogen je actief, bewust en kritisch te begeven in de digitale wereld.” Aan het woord zijn Margreet Luinge en Mickey Touwslager, experts op het gebied van digitale geletterdheid. Vanwege hun expertise zijn ze gevraagd de leerlijn voor de nieuwe cursus ‘Media’ te schrijven die volgend jaar verschijnt in de nieuwe editie van Nieuw Nederlands. Digitale geletterdheid krijgt een belangrijke plek in de lesmethode Nederlands. “Dat vind ik heel verstandig,” zegt Touwslager. “Digitaal ongeletterden zijn de analfabeten van de toekomst”

Digitale geletterdheid, een nieuwe cursus media en een app die verliefdheid meet.

Kritisch leren kijken naar media, naar betrouwbaarheid van bronnen én naar technologie. Het zijn onmisbare vaardigheden in de digitale wereld, waarin informatie met één druk op de knop te vinden is. Gelukkig kun je al die vaardigheden leren: “Digitale geletterdheid is het vermogen je actief, bewust en kritisch te begeven in de digitale wereld.” Aan het woord zijn Margreet Luinge en Mickey Touwslager, experts op het gebied van digitale geletterdheid. Vanwege hun expertise zijn ze gevraagd de leerlijn voor de nieuwe cursus ‘Media’ te schrijven die volgend jaar verschijnt in de nieuwe editie van Nieuw Nederlands. Digitale geletterdheid krijgt een belangrijke plek in de lesmethode Nederlands. “Dat vind ik heel verstandig,” zegt Touwslager. “Digitaal ongeletterden zijn de analfabeten van de toekomst”

High-performance solution-processed polymer ferroelectric field-effect transistors

We demonstrate a rewritable, non-volatile memory device with flexible plastic active layers deposited from solution. The memory device is a ferroelectric field-effect transistor (FeFET) made with a ferroelectric fluoropolymer and a bisalkoxy-substituted poly(p-phenylene vinylene) semiconductor material. The on- and off-state drain currents differ by several orders of magnitude, and have a long retention time, a high programming cycle endurance and short programming time. The remanent semiconductor surface charge density in the on- state has a high value of 18 mC m(-2), which explains the large on/off ratio. Application of a moderate gate field raises the surface charge to 26 mC m(-2), which is of a magnitude that is very difficult to obtain with conventional FETs because they are limited by dielectric breakdown of the gate insulator. In this way, the present ferroelectric-semiconductor interface extends the attainable field-effect band bending in organic semiconductors.</p